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Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB
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To gain global insights into the role of the well-known repressive splicing regulator PTB, we analyzed the consequences of PTB knockdown in HeLa cells using high-density oligonucleotide splice-sensitive microarrays. The major class of identified PTB-regulated splicing event was PTB-repressed cassette exons, but there was also a substantial number of PTB-activated splicing events. PTB-repressed and PTB-activated exons showed a distinct arrangement of motifs with pyrimidine-rich motif enrichment within and upstream of repressed exons but downstream of activated exons. The N-terminal half of PTB was sufficient to activate splicing when recruited downstream of a PTB-activated exon. Moreover, insertion of an upstream pyrimidine tract was sufficient to convert a PTB-activated exon to a PTB-repressed exon. Our results show that PTB, an archetypal splicing repressor, has variable splicing activity that predictably depends upon its binding location with respect to target exons.
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“PTB, a regulator of alternative splicing (Llorian et al., 2010), was the most highly connected protein to both α-synuclein and tau in the ECII network.”
From Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis (2020) · cites this paper as Llorian et al., 2010
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Cites
Alternative isoform regulation in human tissue transcriptomes
Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820
Shapiro, M. B., & Senapathy, P. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.17.7155 · Cited by 2,313
Maximum Entropy Modeling of Short Sequence Motifs with Applications to RNA Splicing Signals
Yeo, G. W.-M., & Burge, C. B. (2004) · Journal of Computational Biology · doi:10.1089/1066527041410418 · Cited by 2,042
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
Understanding alternative splicing: towards a cellular code
Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299
Self-citationMechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179
Splicing regulation: From a parts list of regulatory elements to an integrated splicing code
Wang, Z., & Burge, C. B. (2008) · RNA · doi:10.1261/rna.876308 · Cited by 1,127
Alternative Splicing: New Insights from Global Analyses
Blencowe, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.023 · Cited by 1,122
Flagged first, then by citations
Research works printed but not linked: 1
- Gooding, C., Roberts, G.C. & Smith, C.W. Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated α-tropomyosin exon. RNA 4, 85–100 (1998).
Cited by
Sorted by citations
Items 101–200 of 261
ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing
Lee, S., Wei, L., Zhang, B., Goering, R., Majumdar, S., Wen, J., Taliaferro, J. M., & Lai, E. C. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009439 · Cited by 46
Shen, M., & Mattox, W. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr713 · Cited by 45
Joshi, A., Coelho, M. B., Kotik-Kogan, O., Simpson, P. J., Matthews, S., Smith, C. W. J., & Curry, S. (2011) · Structure · doi:10.1016/j.str.2011.09.020 · Cited by 45
Self-citationPost-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease
Weskamp, K., Olwin, B. B., & Parker, R. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.12.002 · Cited by 46
Neuropathology of the Alzheimer's continuum: an update
Jellinger, K. A. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3050 · Cited by 52
Polypyrimidine tract-binding proteins are essential for B cell development
Monzón‐Casanova, E., Matheson, L. S., Tabbada, K. A., Zarnack, K., Smith, C. W. J., & Turner, M. (2020) · eLife · doi:10.7554/elife.53557 · Cited by 42
Self-citationEbersberger, S., Hipp, C., Mulorz, M. M., Buchbender, A., Hubrich, D., Kang, H.-S., Martínez‐Lumbreras, S., Kristofori, P., Sutandy, F. X. R., Allcca, L. L., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.07.002 · Cited by 42
Fochi, S., Lorenzi, P., Galasso, M., Stefani, C., Trabetti, E., Zipeto, D., & Romanelli, M. G. (2020) · Genes · doi:10.3390/genes11040402 · Cited by 42
Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching
Dawicki-McKenna, J. M., Felix, A. J., Waxman, E. A., Cheng, C., Amado, D. A., Ranum, P. T., Bogush, A., Dungan, L. V., Maguire, J. A., Gagne, A. L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38273-3 · Cited by 41
Královičová, J., Knut, M., Cross, N. C. P., & Vořechovský, I. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv194 · Cited by 40
RNA binding proteins: a common denominator of neuronal function and dysfunction
Doxakis, E. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1443-7 · Cited by 40
Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Kitamura, K., & Nimura, K. (2021) · Cells · doi:10.3390/cells10040923 · Cited by 38
Tan, L.-Y., Whitfield, P. D., Llorian, M., Monzón‐Casanova, E., Díaz‐Muñoz, M. D., Turner, M., & Smith, C. W. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv429 · Cited by 40
Self-citationAlternative Splicing in Genetic Diseases: Improved Diagnosis and Novel Treatment Options
Bergsma, A. J., van der Wal, E., Broeders, M., van der Ploeg, A. T., & Pijnappel, W. W. M. P. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.008 · Cited by 42
van Bergeijk, P., Seneviratne, U. I., Aparicio-Prat, E., Stanton, R. V., & Hasson, S. A. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00568-18 · Cited by 37
PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells
Iannone, C., Kainov, Y. A., Zhuravskaya, A., Hamid, F., Nojima, T., & Makeyev, E. V. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.12.014 · Cited by 34
Nazim, M., Lin, C.-H., Feng, A., Xiao, W., Yeom, K., Li, M., Daly, A. E., Tan, X., Vu, H., Ernst, J., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.04.001 · Cited by 36
Keppetipola, N., Yeom, K., Lopez, A. L. H., Bui, T., Sharma, S., & Black, D. L. (2016) · RNA · doi:10.1261/rna.057505.116 · Cited by 35
Splicing Dysregulation as Oncogenic Driver and Passenger Factor in Brain Tumors
Bielli, P., Pagliarini, V., Pieraccioli, M., Caggiano, C., & Sette, C. (2019) · Cells · doi:10.3390/cells9010010 · Cited by 34
Carroll, T., Guha, S. K., Nehrke, K. W., & Johnson, G. V. W. (2021) · Biology · doi:10.3390/biology10101047 · Cited by 39
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer
He, X., Yuan, C., & Yang, J. (2015) · Oncotarget · doi:10.18632/oncotarget.4865 · Cited by 35
The role of RNA splicing factor PTBP1 in neuronal development
Liu, H., Lu, X., Wang, H.-Y., Hu, K., Wu, Q., Liao, P., Li, S., Long, Z.-Y., & Wang, Y. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119506 · Cited by 38
Hamid, F., & Makeyev, E. V. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004771 · Cited by 31
A mechanism underlying position-specific regulation of alternative splicing
Hamid, F., & Makeyev, E. V. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx901 · Cited by 33
Ji, X., Humenik, J., Yang, D., & Liebhaber, S. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1255 · Cited by 33
Cao, J., Routh, A. L., & Kuyumcu‐Martinez, M. N. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16795 · Cited by 32
Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control
Taylor, K., & Sobczak, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145161 · Cited by 32
Characterization of the Regulation of CD46 RNA Alternative Splicing
Tang, S. J., Luo, S., Ho, J. X. J., Ly, P. T., Goh, E., & Roca, X. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.710350 · Cited by 32
An improved iCLIP protocolPreprint
Lee, F. C. Y., Chakrabarti, A. M., Hänel, H., Monzón‐Casanova, E., Hallegger, M., Militti, C., Capraro, F., Sadée, C., Toolan-Kerr, P., Wilkins, O. G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.27.457890 · Cited by 31
Selective neuronal vulnerability in Alzheimer’s disease: a network-based analysisPreprint
Roussarie, J.-P., Yao, V., Plautz, Z., Kasturia, S. E., Albornoz, C. A., Schmidt, E. F., Brichta, L., Barnea-Cramer, A. O., Heintz, N., Hof, P. R., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/499897 · Cited by 31
Zubović, L., Baralle, M., & Baralle, F. E. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks249 · Cited by 30
RetractedTranscriptomic profile analysis of mouse neural tube development by RNA‐Seq
Yu, J., Mu, J., Guo, Q., Yang, L., Zhang, J., Liu, Z., Yu, B., Zhang, T., & Xie, J. (2017) · IUBMB Life · doi:10.1002/iub.1653 · Cited by 28
Post-Translational Modifications in Polypyrimidine Tract Binding Proteins PTBP1 and PTBP2
Pina, J. M., Reynaga, J., Truong, A., & Keppetipola, N. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00256 · Cited by 33
Coelho, M. B., Ascher, D. B., Gooding, C., Lang, E., Maude, H., Turner, D. A., Llorian, M., Pires, D. E. V., Attig, J., & Smith, C. W. J. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160080 · Cited by 28
Self-citationEngels, B., Jannot, G., Reményi, J., Simard, M. J., & Hutvágner, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033144 · Cited by 29
Regulation of Alternative Pre-mRNA Splicing
Coelho, M. B., & Smith, C. W. J. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-980-2_5 · Cited by 29
Self-citationMatrin3: connecting gene expression with the nuclear matrix
Coelho, M. B., Attig, J., Ule, J., & Smith, C. W. J. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1336 · Cited by 28
Self-citationShan, H., Hou, P., Zhang, M., Li, L., Pan, Y., Chen, F., Jiang, T., Bai, J., & Zheng, J. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4296 · Cited by 28
Dorn, G., Gmeiner, C., de Vries, T., Dedic, E., Novakovic, M., Damberger, F. F., Maris, C., Finol, E., Sarnowski, C. P., Kohlbrecher, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42012-z · Cited by 27
King, H. A., Cobbold, L. C., Pichon, X., Pöyry, T. A. A., Wilson, L. A., Booden, H., Jukes‐Jones, R., Cain, K., Lilley, K. S., Bushell, M., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.135 · Cited by 30
Combinatorial Mutagenesis of MBNL1 Zinc Fingers Elucidates Distinct Classes of Regulatory Events
Purcell, J., Oddo, J. C., Wang, E. T., & Berglund, J. A. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00274-12 · Cited by 29
Fragkouli, A., Koukouraki, P., Vlachos, I. S., Paraskevopoulou, M. D., Hatzigeorgiou, A. G., & Doxakis, E. (2017) · Scientific Reports · doi:10.1038/srep44507 · Cited by 27
Context-dependent splicing regulation
Ke, S., & Chasin, L. A. (2011) · RNA Biology · doi:10.4161/rna.8.3.14458 · Cited by 29
hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer
Jin, Z., Liang, F., Yang, J., & Mei, W. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006672 · Cited by 26
Molecular design of a splicing switch responsive to the RNA binding protein Tra2
Grellscheid, S., Dalgliesh, C., Rozanska, A. L., Grellscheid, D., Bourgeois, C. F., Stévenin, J., & Elliott, D. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr495 · Cited by 25
Ye, J., Llorian, M., Cardona, M., Rongvaux, A., Moubarak, R. S., Comella, J. X., Bassel‐Duby, R., Flavell, R. A., Olson, E. N., Smith, C. W. J., et al. (2013) · Journal of Cell Science · doi:10.1242/jcs.121384 · Cited by 24
Self-citationWongpalee, S. P., Vashisht, A. A., Sharma, S., Chui, D., Wohlschlegel, J. A., & Black, D. L. (2016) · eLife · doi:10.7554/elife.19743 · Cited by 23
Qin, W., Kong, N., Zhang, Y., Wang, C., Dong, S., Zhai, H., Zhai, X., Yang, X., Ye, C., Ye, M., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104987 · Cited by 24
Li, D., Wang, X., Miao, H., Liu, H., Pang, M., Guo, H., Ge, M., Glass, S. E., Emmrich, S., Ji, S., et al. (2023) · Science Signaling · doi:10.1126/scisignal.adh4210 · Cited by 22
Maris, C., Jayne, S., Damberger, F. F., Beusch, I., Dorn, G., Ravindranathan, S., & Allain, F. H. ‐. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa155 · Cited by 23
Genome‐wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis
Zhang, Y., Lin, J., Ren, Z., Chen, C., Miki, D., Xie, S., Zhang, J., Chang, Y., Jiang, J., Yan, J., et al. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13068 · Cited by 23
Human polypyrimidine tract-binding protein interacts with mitochondrial tRNAThrin the cytosol
Marnef, A., Jády, B. E., & Kiss, T. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1355 · Cited by 22
Succession of splicing regulatory elements determines cryptic 5′ss functionality
Brillen, A.-L., Schöneweis, K., Walotka, L., Hartmann, L., Müller, L., Ptok, J., Kaisers, W., Poschmann, G., Stühler, K., Buratti, E., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1317 · Cited by 22
Yamazaki, T., Liu, L., & Manley, J. L. (2019) · RNA · doi:10.1261/rna.072298.119 · Cited by 22
Chen, X., Liu, H., Li, S., Hu, K., Wu, Q., Liao, P., Wang, H., Long, Z., Lu, X., & Wang, Y. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1740 · Cited by 20
Bebee, T. W., Cieply, B. W., & Carstens, R. P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-1221-6_8 · Cited by 23
Regulation of alternative splicing and polyadenylation in neurons
Lee, S., Aubee, J. I., & Lai, E. C. (2023) · Life Science Alliance · doi:10.26508/lsa.202302000 · Cited by 21
Chembazhi, U. V., Tung, W., Hwang, H., Wang, Y., Lalwani, A., Nguyen, K. L., Bangru, S., Yee, D., Chin, K., Yang, J., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad042 · Cited by 22
Tassinari, V., Rosa, P. L., Guida, E., Colopi, A., Caratelli, S., Paolis, F. D., Gallo, A., Cenciarelli, C., Sconocchia, G., Dolci, S., et al. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111807 · Cited by 19
The combinatorial control of alternative splicing in C. elegans
Tan, J. H., & Fraser, A. G. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007033 · Cited by 18
Brooks, A. N., Aspden, J. L., Podgornaia, A., Rio, D. C., & Brenner, S. E. (2011) · RNA · doi:10.1261/rna.2696311 · Cited by 19
Interplay between coding and exonic splicing regulatory sequencesPreprint
Fontrodona, N., Aubé, F., Claude, J., Polvèche, H., Lemaire, S., Tranchevent, L.-C., Modolo, L., Mortreux, F., Bourgeois, C. F., & Auboeuf, D. (2019) · Genome Research · doi:10.1101/gr.241315.118 · Cited by 17
RNA Pol II inhibition activates cell death independently from the loss of transcription
Harper, N. W., Birdsall, G. A., Honeywell, M. E., Ward, K. M., Pai, A. A., & Lee, M. J. (2025) · Cell · doi:10.1016/j.cell.2025.07.034 · Cited by 18
Bahrami‐Samani, E., Vo, D. T., Araujo, P. R. D., Vogel, C., Smith, A. D., Penalva, L. O. F., & Uren, P. J. (2014) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1274 · Cited by 15
A developmentally regulated spliced variant of PTBP1 is upregulated in type 1 diabetic hearts
Belanger, K. K., Nutter, C. A., Li, J., Yu, P., & Kuyumcu‐Martinez, M. N. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.150 · Cited by 17
Joshi, A., Esteve, V., Buckroyd, A., Blatter, M., Allain, F. H. ‐., & Curry, S. (2014) · PeerJ · doi:10.7717/peerj.305 · Cited by 15
Roy, D., Chowdhury, J. B., & Ghosh, S. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.10.005 · Cited by 15
Alternative splicing ofU2AF1reveals a shared repression mechanism for duplicated exons
Královičová, J., & Vořechovský, I. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw733 · Cited by 15
Wang, Y., Chembazhi, U. V., Yee, D., Chen, S., Ji, J., Wang, Y., Nguyen, K. L., Lin, P.-C. P., Ratti, A., Hess, R. A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae862 · Cited by 14
mRNA isoform balance in neuronal development and disease
LaForce, G. R., Philippidou, P., & Schaffer, A. E. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1762 · Cited by 15
The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression
Lan, C., Zhang, H., Wang, K., Liu, X., Zhao, Y., Guo, Z., Zhang, N., Zhou, Y., Gao, M., Gu, F., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05238-1 · Cited by 15
Cheng, Y., Wang, N., Zhao, L., Liu, C., Wang, J., Ma, C., & Shi, X. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.07.016 · Cited by 13
Multiple roles of RBM4 in muscle cell differentiation
Lin, J.-C. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/260 · Cited by 17
Dissecting domains necessary for activation and repression of splicing by muscleblind-like protein 1
Edge, C., Gooding, C., & Smith, C. W. J. (2013) · BMC Molecular Biology · doi:10.1186/1471-2199-14-29 · Cited by 15
Self-citationTavanez, J. P., & Valcárcel, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.234 · Cited by 13
Post-transcriptional mechanisms controlling neurogenesis and direct neuronal reprogramming
Papadimitriou, E., & Thomaidou, D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390976 · Cited by 14
Liu, Y., Ren, J. M., Zhang, W., Ding, L., Ma, R., Zhang, M., Zheng, S., Liang, R., & Zheng, S. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122707 · Cited by 12
Post-transcriptional regulation of the transcriptional apparatus in neuronal development
Nazim, M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1483901 · Cited by 12
Královičová, J., Moreno, P. M. D., Cross, N. C. P., Pêgo, A. P., & Vořechovský, I. (2016) · Nucleic Acid Therapeutics · doi:10.1089/nat.2016.0635 · Cited by 12
Rationally designed stapled peptides allosterically inhibit PTBP1–RNA-binding
Schmeing, S., Amrahova, G., Bigler, K., Chang, J., Openy, J., Pal, S., Posada, L., Gasper, R., & Hart, P. ‘. (2023) · Chemical Science · doi:10.1039/d3sc00985h · Cited by 12
Hernández-Imaz, E., Martín, Y., Conti, L. D., Melean, G., Valero, A., Baralle, M., & Hernández-Chico, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141735 · Cited by 12
Mapping of In Vivo RNA-Binding Sites by Ultraviolet (UV)-Cross-Linking Immunoprecipitation (CLIP)Preprint
Darnell, J. C., Mele, A., Hung, K. Y. S., & Darnell, R. B. (2018) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top097931 · Cited by 12
Challenges in Therapeutically Targeting the RNA‐Recognition Motif
Schmeing, S., & Hart, P. '. (2024) · WIREs RNA · doi:10.1002/wrna.1877 · Cited by 11
Fontana, L., Rovina, D., Novielli, C., Maffioli, E., Tedeschi, G., Magnani, I., & Larizza, L. (2015) · Cancer Letters · doi:10.1016/j.canlet.2014.12.049 · Cited by 11
Human NDE1 splicing and mammalian brain development
Mosca, S., Raponi, M., Meneghello, A., Buratti, E., Woods, C. G., & Baralle, D. (2017) · Scientific Reports · doi:10.1038/srep43504 · Cited by 11
Razpotnik, R., Nassib, P., Kunej, T., Rozman, D., & Režen, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147477 · Cited by 12
Splicing to orchestrate cell fate
Zhang, X., Guo, Z., Li, Y., & Xu, Y. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102416 · Cited by 10
Frequent Gain and Loss of Intronic Splicing Regulatory Elements during the Evolution of Vertebrates
Voelker, R. B., Erkelenz, S., Reynoso, V., Schaal, H., & Berglund, J. A. (2012) · Genome Biology and Evolution · doi:10.1093/gbe/evs051 · Cited by 9
A Posttranscriptional Mechanism That Controls Ptbp1 Abundance in the Xenopus Epidermis
Méreau, A., Anquetil, V., Lerivray, H., Viet, J., Schirmer, C., Audic, Y., Legagneux, V., Hardy, S., & Paillard, L. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01040-14 · Cited by 9
Callari, M., Guffanti, A., Soldà, G., Merlino, G., Fina, E., Brini, E., Moles, A., Cappelletti, V., & Daidone, M. G. (2015) · Oncotarget · doi:10.18632/oncotarget.5810 · Cited by 9
U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays
Dao, K., Jungers, C. F., Djuranović, S., & Mustoe, A. M. (2025) · Nature Communications · doi:10.1038/s41467-025-62000-9 · Cited by 11
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Metadata
- Authors
- Llorian, M., Schwartz, S., Clark, T. A., Hollander, D., Tan, L.-Y., Spellman, R., Gordon, A., Schweitzer, A. C., de la Grange, P., Ast, G., & Smith, C. W. J.
- Affiliations
- University of Cambridge (GB)
- Tel Aviv University (IL)
- Affymetrix (United States) (US)
- Institute of Cancer Research (GB)
- Corresponding author
- Smith, Christopher W J
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-08-15
- Volume
- 17
- Issue
- 9
- Pages
- 1114-1123
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC2933513
- OpenAlex
- W2042086006
- Cited by
- 263
- References
- 69
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 15 · 2023: 22 · 2022: 9 · 2021: 15 · 2020: 12 · 2019: 8 · 2018: 17 · 2017: 15 · 2016: 17 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 28
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (077877)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- polypyrimidine tract-binding protein, PTB, alternative splicing, splicing regulation, cassette exons, HeLa cells
- MeSH terms
- Base Sequence, Exons, HeLa Cells, Humans, Introns, Molecular Sequence Data, Alternative Splicing, Oligonucleotide Array Sequence Analysis, Silencer Elements, Transcriptional, Polypyrimidine Tract-Binding Protein
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