The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
Open accessAbstract
The role of Rad51 in an unperturbed cell cycle has been difficult to distinguish from its DNA repair function. Here, using EM to visualize replication intermediates assembled in Xenopus laevis egg extract, we show that Rad51 is required to prevent the accumulation of single-stranded DNA (ssDNA) gaps at replication forks and behind them. ssDNA gaps at forks arise from extended uncoupling of leading- and lagging-strand DNA synthesis. In contrast, ssDNA gaps behind forks, which are prevalent on damaged templates, result from Mre11-dependent degradation of newly synthesized DNA strands and are suppressed by inhibition of Mre11 nuclease activity. These findings reveal direct roles for Rad51 at replication forks, demonstrating that Rad51 protects newly synthesized DNA from Mre11-dependent degradation and promotes continuous DNA synthesis.
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Cites
PCNA, the Maestro of the Replication Fork
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796 · cited 1×
“This polymerase switching requires monoubiquitination of proliferating cell nuclear antigen (PCNA) at Lys164 mediated by the Rad6–Rad18 comple”
BackgroundEUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function
Prakash, S., Johnson, R. E., & Prakash, L. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133250 · Cited by 1,000
Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair
Symington, L. S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.630-670.2002 · Cited by 975
Molecular views of recombination proteins and their control
West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 956
Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis
McGarry, T. J., & Kirschner, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81209-x · Cited by 897
Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects
Sogo, J. M., Lopes, M., & Foiani, M. (2002) · Science · doi:10.1126/science.1074023 · Cited by 823
Self-citationRecombination Proteins in Yeast
Krogh, B. O., & Symington, L. S. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091500 · Cited by 805
Genome instability: a mechanistic view of its causes and consequences
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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
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Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
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Cited by
Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,255
Schlacher, K., Wu, H., & Jasin, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.015 · Cited by 936
Replication fork stability confers chemoresistance in BRCA-deficient cells
Ray Chaudhuri, A., Callen, E., Ding, X., Gogola, E., Duarte, A. A., Lee, J.-E., Wong, N., Lafarga, V., Calvo, J. A., Panzarino, N. J., et al. (2016) · Nature · doi:10.1038/nature18325 · Cited by 930
Self-citationThe MRE11 complex: starting from the ends
Stracker, T. H., & Petrini, J. H. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3047 · Cited by 734
The Fanconi anaemia pathway: new players and new functions
Ceccaldi, R., Sarangi, P., & D'Andrea, A. D. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.48 · Cited by 720
Metadata
- Authors
- Hashimoto, Y., Ray Chaudhuri, A., Lopes, M., & Costanzo, V.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-10-10
- Volume
- 17
- Issue
- 11
- Pages
- 1305-1311
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2146533600
- Cited by
- 548
- References
- 47
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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