The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa
Open accessAbstract
In mammalian spermatozoa, most but not all of the genome is densely packaged by protamines. Here we reveal the molecular logic underlying the retention of nucleosomes in mouse spermatozoa, which contain only 1% residual histones. We observe high enrichment throughout the genome of nucleosomes at CpG-rich sequences that lack DNA methylation. Residual nucleosomes are largely composed of the histone H3.3 variant and are trimethylated at Lys4 of histone H3 (H3K4me3). Canonical H3.1 and H3.2 histones are also enriched at CpG-rich promoters marked by Polycomb-mediated H3K27me3, a modification predictive of gene repression in preimplantation embryos. Histone variant–specific nucleosome retention in sperm is strongly associated with nucleosome turnover in round spermatids. Our data show evolutionary conservation of the basic principles of nucleosome retention in mouse and human sperm, supporting a model of epigenetic inheritance by nucleosomes between generations.
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DNA-binding factors shape the mouse methylome at distal regulatory regions
Stadler, M. B., Murr, R., Burger, L., Ivanek, R., Lienert, F., Schöler, A., Nimwegen, E. V., Wirbelauer, C., Oakeley, E. J., Gaidatzis, D., et al. (2011) · Nature · doi:10.1038/nature10716 · Cited by 1,383
Self-citationGenome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules
Kelly, T. K., Liu, Y., Lay, F. D., Liang, G., Berman, B. P., & Jones, P. A. (2012) · Genome Research · doi:10.1101/gr.143008.112 · Cited by 455
Multigenerational epigenetic adaptation of the hepatic wound-healing response
Zeybel, M., Hardy, T., Wong, Y. K., Mathers, J. C., Fox, C. R., Gackowska, A., Oakley, F., Burt, A. D., Wilson, C. L., Anstee, Q. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2893 · Cited by 279
Cited by
Histone post-translational modifications - cause and consequence of genome function
Millán-Zambrano, G., Burton, A., Bannister, A. J., & Schneider, R. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00468-7 · Cited by 1,116
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally
Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., Cohen, T., Xia, J., Suderman, M., Hallett, M., et al. (2015) · Science · doi:10.1126/science.aab2006 · Cited by 521
Self-citationFunctions and mechanisms of epigenetic inheritance in animals
Skvortsova, K., Iovino, N., & Bogdanović, O. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0074-2 · Cited by 517
Lambrot, R., Xu, C., Saint-Phar, S., Chountalos, G., Cohen, T., Paquet, M., Suderman, M., Hallett, M., & Kimmins, S. (2013) · Nature Communications · doi:10.1038/ncomms3889 · Cited by 473
The roles of histone variants in fine-tuning chromatin organization and function
Martire, S., & Banaszynski, L. A. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0262-8 · Cited by 392
Metadata
- Authors
- Erkek, S., Hisano, M., Liang, C.-Y., Gill, M., Murr, R., Dieker, J., Schübeler, D., Vlag, J. V. D., Stadler, M. B., & Peters, A. H. F. M.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2013-06-16
- Volume
- 20
- Issue
- 7
- Pages
- 868-875
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2103163808
- Cited by
- 367
- References
- 3
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Erkek, S., Hisano, M., Liang, C.-Y., Gill, M., Murr, R., Dieker, J., Schübeler, D., Vlag, J. V. D., Stadler, M. B., & Peters, A. H. F. M. (2013). Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.2599
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