Histone post-translational modifications - cause and consequence of genome function

Millán-Zambrano, Gonzalo; Burton, Adam; Bannister, Andrew J.; Schneider, Robert

doi:10.1038/s41576-022-00468-7

Cited by 1,116Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

Histone post-translational modifications - cause and consequence of genome function

Millán-Zambrano, Gonzalo, Burton, Adam, Bannister, Andrew J., Schneider, Robert·2022·Nature Reviews Genetics

DOI 10.1038/s41576-022-00468-7

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Abstract

Much has been learned since the early 1960s about histone post-translational modifications (PTMs) and how they affect DNA-templated processes at the molecular level. This understanding has been bolstered in the past decade by the identification of new types of histone PTM, the advent of new genome-wide mapping approaches and methods to deposit or remove PTMs in a locally and temporally controlled manner. Now, with the availability of vast amounts of data across various biological systems, the functional role of PTMs in important processes (such as transcription, recombination, replication, DNA repair and the modulation of genomic architecture) is slowly emerging. This Review explores the contribution of histone PTMs to the regulation of genome function by discussing when these modifications play a causative (or instructive) role in DNA-templated processes and when they are deposited as a consequence of such processes, to reinforce and record the event. Important advances in the field showing that histone PTMs can exert both direct and indirect effects on genome function are also presented.

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Post-translational modifications predominantly occur on N-terminal histone tails and include acetylation, methylation, phosphorylation, and ubiquitination, forming combinatorial patterns known as the histone code.
“These PTMs predominantly occur on the N-terminal histone tails and include acetylation, methylation, phosphorylation, and ubiquitination, forming combinatorial patterns often referred to as the “histone code,” which influences transcription in a context-dependent manner (Millán-Zambrano et al., 2022; Miziak et al., 2024; Jenuwein and Allis, 2001; Lam et al., 2019).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Millán-Zambrano et al., 2022
The flexible N-terminal tails of histones protrude from the nucleosome and serve as major sites for post-translational modifications including acetylation, methylation, and phosphorylation.
“The flexible N-terminal tails of histones protrude from the nucleosome and serve as major sites for post-translational modifications (PTMs), including acetylation, methylation, and phosphorylation (Millán-Zambrano et al., 2022; Le et al., 2023).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Millán-Zambrano et al., 2022

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Authors: Millán-Zambrano, G., Burton, A., Bannister, A. J., & Schneider, R.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Helmholtz Munich (DE)
University of Cambridge (GB)
Corresponding author: Bannister, Andrew J.
Schneider, Robert
ORCID: Millán-Zambrano, Gonzalo
Burton, Adam
Bannister, Andrew J.
Schneider, Robert
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2022-03-25
Volume: 23
Issue: 9
Pages: 563-580
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/s41576-022-00468-7
OpenAlex: W4220743473
Semantic Scholar: 4a452bb0c38ba013f3a90217102ab8f7caf3fdaf
Cited by: 1,116
References: 238
Citations by year: 2026: 241 · 2025: 335 · 2024: 333 · 2023: 170 · 2022: 37
FWCI: 23.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Site cant be reached (submittedVersion)
PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Funders: Wellcome Trust (WT203144)
Cancer Research UK (C6946/A24843, 27321, RG96894)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: histone modifications, genome function, transcription, DNA recombination, DNA replication, DNA repair, chromatin structure, genome-wide mapping
MeSH terms: DNA, DNA Repair, DNA Replication, Histones, Protein Processing, Post-Translational

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Histone post-translational modifications - cause and consequence of genome function

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