CATCHR, HOPS and CORVET tethering complexes share a similar architecture
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We show here that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks.
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The resulting GARP model has a striking resemblance to previously published 2D classes from a negative-stain EM analysis of the GARP complex.
“The resulting model has a striking resemblance to previously published 2D classes (fig. S24C) from a negative-stain EM analysis of the GARP complex (77).”
From Computed structures of core eukaryotic protein complexes (2021) · cites this paper as [77]
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Computed structures of core eukaryotic protein complexes
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- Authors
- Chou, H.-T., Dukovski, D., Chambers, M. G., Reinisch, K. M., & Walz, T.
- Affiliations
- Harvard University (US)
- Yale University (US)
- Corresponding author
- Walz, Thomas
- Venue
- Nature Structural & Molecular Biology
- Published
- 2016-07-18
- Volume
- 23
- Issue
- 8
- Pages
- 761-763
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC4972687
- OpenAlex
- W2493174924
- Cited by
- 83
- References
- 20
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 1
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute of General Medical Sciences (R01GM080616, P01GM062580)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- tethering complexes, GARP complex, HOPS complex, COG complex, subunit structure, endolysosomal pathway, Saccharomyces cerevisiae, electron microscopy
- MeSH terms
- Microscopy, Electron, Models, Molecular, Saccharomyces cerevisiae, Protein Structure, Quaternary, Protein Subunits, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins, Vesicular Transport Proteins, Adaptor Proteins, Vesicular Transport, Multiprotein Complexes
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