The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Correlation between Serum Resistin Level and Adiposity in Obese Individuals
Abstract
Objective: Resistin is associated with insulin resistance in mice and may play a similar role in humans. The aim of our study was to examine the relationship of serum resistin level to body composition, insulin resistance, and related obesity phenotypes in humans. Research Methods and Procedures: Sixty‐four young (age 32 ± 10 years), obese (BMI 32.9 ± 5.6), nondiabetic subjects taking no medication, and 15 lean (BMI 21.1 ± 1.3) volunteers were studied cross‐sectionally. Thirty‐five of the subjects were also reevaluated after 1.5 years on a weight reduction program entailing dieting and exercise; changes of serum resistin were compared with changes of BMI, body composition, fat distribution, and several indices of insulin sensitivity derived from plasma glucose and serum insulin levels measured during 75‐g oral glucose tolerance test. Results: In a cross‐sectional analysis, serum resistin was significantly higher in obese subjects than in lean volunteers (24.58 ± 12.93 ng/mL; n = 64 vs. 12.83 ± 8.30 ng/mL; n = 15; p < 0.01), and there was a correlation between resistin level and BMI, when the two groups were combined (ρ = 0.35, p < 0.01). Although cross‐sectional analysis in obese subjects revealed no correlation between serum resistin and parameters related to adiposity or insulin resistance, longitudinal analysis revealed change in serum resistin to be positively correlated with changes in BMI, body fat, fat mass, visceral fat area, and mean glucose and insulin (ρ = 0.39, 0.40, 0.44, 0.50, 0.40, and 0.50; p = 0.02, 0.03, 0.02, <0.01, 0.02, and <0.01, respectively). Discussion: Resistin appears to be related to human adiposity and to be a possible candidate factor in human insulin resistance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Resistin is expressed in human macrophages and directly regulated by PPARγ activators
Patel, L., Buckels, A. C., Kinghorn, I. J., Murdock, P. R., Holbrook, J. D., Plumpton, C., Macphee, C. H., & Smith, S. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02841-3 · Cited by 922
A family of tissue-specific resistin-like molecules
Steppan, C. M., Brown, E. J., Wright, C. M., Bhat, S., Banerjee, R. R., Dai, C. Y., Enders, G. H., Silberg, D. G., Wen, X., Wu, G. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.502 · Cited by 637
Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal-Puig, A., Considine, R. V., & O’Rahilly, S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2199 · Cited by 572
Rajala, M. W., Obici, S., Scherer, P. E., & Rossetti, L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16521 · Cited by 525
Yannakoulia, M., Yiannakouris, N., Blüher, S., Matalas, A.-L., Klimis-Zacas, D., & Mantzoros, C. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021604 · Cited by 428
Resistin, central obesity, and type 2 diabetes
McTernan, C., McTernan, P., Harte, A., Levick, P., Barnett, A., & Kumar, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07281-1 · Cited by 423
Yeni-Komshian, H., Carantoni, M., Abbasi, F., & Reaven, G. M. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.171 · Cited by 414
Nagaev, I., & Smith, U. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5173 · Cited by 380
Cited by
Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans
Reilly, M. P., Lehrke, M., Wolfe, M. L., Rohatgi, A., Lazar, M. A., & Rader, D. J. (2005) · Circulation · doi:10.1161/01.cir.0000155620.10387.43 · Cited by 911
The role of resistin as a regulator of inflammation: Implications for various human pathologies
Filková, M., Haluzík, M., Gay, S., & Šenolt, L. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.07.013 · Cited by 451
Role of resistin in diet-induced hepatic insulin resistance
Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421270 · Cited by 372
Adipose tissue: a regulator of inflammation
Juge-Aubry, C. E., Henrichot, E., & Meier, C. A. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.009 · Cited by 347
Metadata
- Authors
- Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A., & Saruta, T.
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2003-08
- Volume
- 11
- Issue
- 8
- Pages
- 997-1001
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W1973936104
- Cited by
- 370
- References
- 19
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Correlation between Serum Resistin Level and Adiposity in Obese Individuals. https://app.cochat.ai/papers/10.1038/oby.2003.137
- The paper
- Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A., & Saruta, T. (2003). Correlation between Serum Resistin Level and Adiposity in Obese Individuals. Obesity Research. https://doi.org/10.1038/oby.2003.137
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
