Cited by 451Adipokines, Inflammation, and Metabolic DiseasesBiomarkers in Disease MechanismsInflammation biomarkers and pathways

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Open access
Filková, Mária, Haluzík, Martin, Gay, Steffen, Šenolt, Ladislav·2009·Clinical Immunology

Abstract

Resistin was originally described as an adipocyte-secreted peptide that induced insulin resistance in rodents. Increasing evidence indicates its important regulatory roles in various biological processes, including several inflammatory diseases. Further studies have shown that resistin in humans, in contrast to its production by adipocytes in mice, is synthesized predominantly by mononuclear cells both within and outside adipose tissue. Possible roles for resistin in obesity-related subclinical inflammation, atherosclerosis and cardiovascular disease, non-alcoholic fatty liver disease, rheumatic diseases, malignant tumors, asthma, inflammatory bowel disease, and chronic kidney disease have already been demonstrated. In addition, resistin can modulate several molecular pathways involved in metabolic, inflammatory, and autoimmune diseases. In this review, current knowledge about the functions and pathophysiological implications of resistin in different human pathologies is summarized, although there is a significant lack of firm evidence regarding the specific role resistin plays in the "orchestra" of the numerous mediators of inflammation.

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Crossref · 10.1016/j.clim.2009.07.013

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  • The immunopathology of RA is characterized by inappropriate production of various cytokines, in particular TNF, among other immunological abnormalities.

    “The immunopathology in RA is reasonably well understood and is characterized by inappropriate production of various cytokines, in particular TNF, among several other immunological abnormalities (94, 188).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [188]

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Authors
Filková, M., Haluzík, M., Gay, S., & Šenolt, L.
Affiliations
  • Charles University (CZ)
  • University Hospital Zurich (CH)
Corresponding author
Šenolt, Ladislav
Venue
Clinical Immunology
Publisher
Elsevier BV
Published
2009-11
Volume
133
Issue
2
Pages
157-170
ISSN
1521-6616 (ISSN-L)
OpenAlex
W2035915584
Cited by
451
References
142
Citations by year
2026: 11 · 2025: 13 · 2024: 47 · 2023: 29 · 2022: 39 · 2021: 40 · 2020: 31 · 2019: 20 · 2018: 26 · 2017: 24 · 2016: 27 · 2015: 27 · 2014: 25 · 2013: 39 · 2012: 20
FWCI
2.16
Type
journal article
Language
en
Open access
Locations
  • Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
resistin, inflammation, adipokines, mononuclear cells, obesity, subclinical inflammation, atherosclerosis, cardiovascular disease, non-alcoholic fatty liver disease, rheumatic diseases, cancer, asthma, inflammatory bowel disease, chronic kidney disease, insulin resistance, adipose tissue
MeSH terms
Animals, Humans, Inflammation, Neoplasms, Obesity, Resistin

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