The role of resistin as a regulator of inflammation: Implications for various human pathologies
Open accessAbstract
Resistin was originally described as an adipocyte-secreted peptide that induced insulin resistance in rodents. Increasing evidence indicates its important regulatory roles in various biological processes, including several inflammatory diseases. Further studies have shown that resistin in humans, in contrast to its production by adipocytes in mice, is synthesized predominantly by mononuclear cells both within and outside adipose tissue. Possible roles for resistin in obesity-related subclinical inflammation, atherosclerosis and cardiovascular disease, non-alcoholic fatty liver disease, rheumatic diseases, malignant tumors, asthma, inflammatory bowel disease, and chronic kidney disease have already been demonstrated. In addition, resistin can modulate several molecular pathways involved in metabolic, inflammatory, and autoimmune diseases. In this review, current knowledge about the functions and pathophysiological implications of resistin in different human pathologies is summarized, although there is a significant lack of firm evidence regarding the specific role resistin plays in the "orchestra" of the numerous mediators of inflammation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The immunopathology of RA is characterized by inappropriate production of various cytokines, in particular TNF, among other immunological abnormalities.
“The immunopathology in RA is reasonably well understood and is characterized by inappropriate production of various cytokines, in particular TNF, among several other immunological abnormalities (94, 188).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [188]
Cites
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,196 · see citing works
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606 · see citing works
Adipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113 · see citing works
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Mammalian Gene Collection (MGC) Program Team* (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242603899 · Cited by 1,742 · see citing works
Resistin, an Adipokine with Potent Proinflammatory Properties
Bokarewa, M. I., Nagaev, I., Dahlberg, L., Smith, U., & Tarkowski, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5789 · Cited by 1,037 · see citing works
Mechanisms of Disease: is osteoporosis the obesity of bone?
Rosen, C. J., & Bouxsein, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0070 · Cited by 961 · see citing works
Wisse, B. E. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000141966.69934.21 · Cited by 933 · see citing works
Resistin is expressed in human macrophages and directly regulated by PPARγ activators
Patel, L., Buckels, A. C., Kinghorn, I. J., Murdock, P. R., Holbrook, J. D., Plumpton, C., Macphee, C. H., & Smith, S. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02841-3 · Cited by 920 · see citing works
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans
Reilly, M. P., Lehrke, M., Wolfe, M. L., Rohatgi, A. K., Lazar, M. A., & Rader, D. J. (2005) · Circulation · doi:10.1161/01.cir.0000155620.10387.43 · Cited by 909 · see citing works
Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., & Pratley, R. E. (2000) · Diabetologia · doi:10.1007/s001250051560 · Cited by 799 · see citing works
Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal‐Puig, A., Considine, R. V., & O’Rahilly, S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2199 · Cited by 748 · see citing works
Adipokines: The missing link between insulin resistance and obesity
Antuna-Puente, B. P., Fève, B., Fellahi, S., & Bastard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.09.004 · Cited by 738 · see citing works
Regulation of Fasted Blood Glucose by Resistin
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works
Resistin Promotes Endothelial Cell Activation
Verma, S., Li, S., Wang, C., Fedak, P. W. M., Li, R., Weisel, R. D., & Mickle, D. A. G. (2003) · Circulation · doi:10.1161/01.cir.0000084503.91330.49 · Cited by 670 · see citing works
Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A. L., Henzel, W. J., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4046 · Cited by 658 · see citing works
Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643 · see citing works
A family of tissue-specific resistin-like molecules
Steppan, C. M., Brown, E. J., Wright, C. M., Bhat, S., Banerjee, R. R., Dai, C. Y., Enders, G. H., Silberg, D. G., Wen, X., Wu, G. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.502 · Cited by 635 · see citing works
Silswal, N., Singh, A., Battu, A., Mukhopadhyay, S., Ghosh, S., & Ehtesham, N. Z. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.202 · Cited by 628 · see citing works
Otero, M., Lago, R., Gómez, R., Lago, F., Diéguez, C., Gómez-Reino, J. J., & Gualillo, O. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.046540 · Cited by 541 · see citing works
Rajala, M. W., Obici, S., Scherer, P. E., & Rossetti, L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16521 · Cited by 525 · see citing works
An Inflammatory Cascade Leading to Hyperresistinemia in Humans
Lehrke, M., Reilly, M. P., Millington, S. C., Iqbal, N., Rader, D. J., & Lazar, M. A. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010045 · Cited by 523 · see citing works
Serum Resistin (FIZZ3) Protein Is Increased in Obese Humans
Degawa‐Yamauchi, M., Bovenkerk, J. E., Juliar, B. E., Watson, W., Kerr, K. A., Jones, R., Zhu, Q., & Considine, R. V. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021808 · Cited by 475 · see citing works
Koerner, A., Kratzsch, J., & Kiess, W. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.008 · Cited by 471 · see citing works
Kawanami, D., Maemura, K., Takeda, N., Harada, T., Nojiri, T., Imai, Y., Manabe, I., Utsunomiya, K., & Nagai, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.104 · Cited by 470 · see citing works
Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro
Kaser, S., Kaser, A., Sandhofer, A., Ebenbichler, C. F., Tilg, H., & Patsch, J. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.07.003 · Cited by 460 · see citing works
Adipokines and cytokines in non‐alcoholic fatty liver disease
Jarrar, M. H., Baranova, A. V., Collantes, R. S., Ranard, B. L., Stepanova, M., Bennett, C., Fang, Y. H., Elariny, H. A., Goodman, Z. D., Chandhoke, V., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03586.x · Cited by 430 · see citing works
Resistin, central obesity, and type 2 diabetes
McTernan, C. L., McTernan, P. G., Harte, A. L., Levick, P., Barnett, A. H., & Kumar, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07281-1 · Cited by 421 · see citing works
Adipocytokines - novel link between inflammation and vascular function?
Guzik, T. J., Mangalat, D., & Korbut, R. (2006) · PubMed · Cited by 420 · see citing works
Role of resistin in diet-induced hepatic insulin resistance
Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21270 · Cited by 371 · see citing works
Correlation between Serum Resistin Level and Adiposity in Obese Individuals
Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A., & Saruta, T. (2003) · Obesity Research · doi:10.1038/oby.2003.137 · Cited by 369 · see citing works
Luo, X., Guo, L., Xie, H., Yuan, L., Wu, X., Zhou, H., & Liao, E.-Y. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060707 · Cited by 369 · see citing works
Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis
Sluimer, J. C., & Daemen, M. J. A. P. (2009) · The Journal of Pathology · doi:10.1002/path.2518 · Cited by 368 · see citing works
Di Gregorio, G. B., Yao-Borengasser, A., Rasouli, N., Varma, V., Lu, T., Miles, L. M., Ranganathan, G., Peterson, C. A., McGehee, R. E., & Kern, P. A. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2305 · Cited by 362 · see citing works
Mechanisms of Disease: atherosclerosis in autoimmune diseases
Sherer, Y., & Shoenfeld, Y. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0092 · Cited by 357 · see citing works
Adipose tissue: a regulator of inflammation
Juge-Aubry, C. E., Henrichot, E., & Meier, C. A. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.009 · Cited by 350 · see citing works
Increased Resistin Gene and Protein Expression in Human Abdominal Adipose Tissue
McTernan, P. G., McTernan, C. L., Chetty, R., Jenner, K., Fisher, F. M., Lauer, M. N., Crocker, J., Barnett, A. H., & Kumar, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8627 · Cited by 350 · see citing works
Reseland, J. E., Syversen, U., Bakke, I., Qvigstad, G., Eide, L. G., Hjertner, Ø., Gordeladze, J. O., & Drevon, C. A. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.8.1426 · Cited by 345 · see citing works
Calabrò, P., Samudio, I. J., Willerson, J. T., & Yeh, E. T. H. (2004) · Circulation · doi:10.1161/01.cir.0000147825.97879.e7 · Cited by 330 · see citing works
RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
Artis, D., Wang, M. L., Keilbaugh, S. A., He, W., Brenes, M., Swain, G. P., Knight, P. A., Donaldson, D. D., Lazar, M. A., Miller, H. R. P., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404034101 · Cited by 326 · see citing works
Therapeutic angiogenesis in cardiovascular disease
Simons, M., & Ware, J. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1226 · Cited by 325 · see citing works
Resistin Gene Expression in Human Adipocytes Is Not Related to Insulin Resistance
Janke, J., Engeli, S., Gorzelniak, K., Luft, F. C., & Sharma, A. M. (2002) · Obesity Research · doi:10.1038/oby.2002.1 · Cited by 318 · see citing works
Heilbronn, L. K., Rood, J. C., Janderova, L., Albu, J., Kelley, D. E., Ravussin, É., & Smith, S. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031410 · Cited by 307 · see citing works
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones
Patel, S. D., Rajala, M. W., Rossetti, L., Scherer, P. E., & Shapiro, L. S. (2004) · Science · doi:10.1126/science.1093466 · Cited by 306 · see citing works
Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease
Κarmiris, K., Κoutroubakis, I. E., Xidakis, C., Polychronaki, M., Voudouri, T., & Kouroumalis, E. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000200345.38837.46 · Cited by 305 · see citing works
Presle, N., Pottie, P., Dumond, H., Guillaume, C., Lapicque, F., Pallu, S., Mainard, D., Netter, P., & Terlain, B. L. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.01.009 · Cited by 290 · see citing works
Activation of SOCS-3 by Resistin
Steppan, C. M., Wang, J., Whiteman, E. L., Birnbaum, M. J., & Lazar, M. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1569-1575.2005 · Cited by 280 · see citing works
Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology
Wang, C. C. L., Goalstone, M. L., & Draznin, B. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2735 · Cited by 269 · see citing works
Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum
Šenolt, L., Housa, D., Vernerová, Z., et al. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.054734 · Cited by 267 · see citing works
Self-citationHousa, D., Housova, J., Vernerová, Z., & Haluzı́k, M. (2006) · Physiological Research · doi:10.33549/physiolres.930848 · Cited by 264 · see citing works
Self-citationResistin is secreted from macrophages in atheromas and promotes atherosclerosis
JUNG, H., Park, K. S., CHO, Y., CHUNG, S., Cho, S., CHO, S., Kim, S. J., KIM, S., LEE, H., & Park, K. S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.09.015 · Cited by 260 · see citing works
The potential role of resistin in atherogenesis
Burnett, M. S., Lee, C. W., Kinnaird, T. D., Stabile, E., Durrani, S., Dullum, M. K. C., Devaney, J. M., Fishman, C., Stamou, S. C., Caños, D., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.02.014 · Cited by 249 · see citing works
Axelsson, J., Bergsten, A., Qureshi, A. R., Heimbürger, O., Barany, P. F., Lönnqvist, F., Lindholm, B., Nordfors, L., Alvestrand, A., & Stenvinkel, P. (2006) · Kidney International · doi:10.1038/sj.ki.5000089 · Cited by 246 · see citing works
Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs
Schäffler, A., Schölmerich, J., & Salzberger, B. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.07.003 · Cited by 244 · see citing works
Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation
Johnston, A. W. B., Árnadóttir, S., Gudjonsson, J. E., Aphale, A., Sigmarsdottir, A., Gunnarsson, S. I., Steinsson, J. T., Elder, J. T., & Valdimarsson, H. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08655.x · Cited by 235 · see citing works
Insulin Resistance and Substrate Utilization in Human Endotoxemia
Agwunobi, A. O., Reid, C. L., Maycock, P. F., Little, R. A., & Carlson, G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6914 · Cited by 229 · see citing works
Adipokine resistin promotes in vitro angiogenesis of human endothelial cells
Mu, H. H., OHASHI, R., YAN, S., Chai, H., Yang, H., LIN, P., YAO, Q., & CHEN, C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.015 · Cited by 209 · see citing works
Gerber, M., Böttner, A., Seidel, B. M., Lammert, A., Bär, J., Schuster, E., Thiery, J., Kiess, W., & Kratzsch, J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0437 · Cited by 208 · see citing works
Thommesen, L., Stunes, A. K., Monjo, M., Grøsvik, K., Tamburstuen, M. V., Kjøbli, E., Lyngstadaas, S. P., Reseland, J. E., & Syversen, U. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20915 · Cited by 206 · see citing works
Comparative studies of resistin expression and phylogenomics in human and mouse
Yang, R., Huang, Q., Xu, A., McLenithan, J. C., Eison, J. A., Shuldiner, A. R., Alkan, S., & Gong, D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.093 · Cited by 203 · see citing works
Resistin and Adiponectin Expression in Visceral Fat of Obese Rats: Effect of Weight Loss
Milan, G., Granzotto, M., Scarda, A., Calcagno, A., Pagano, C., Federspil, G., & Vettor, R. (2002) · Obesity Research · doi:10.1038/oby.2002.149 · Cited by 199 · see citing works
Innate Immunity Modulates Adipokines in Humans
Anderson, P. D., Mehta, N. N., Wolfe, M. L., Hinkle, C. C., Pruscino, L., Comiskey, L., Tabita‐Martinez, J., Sellers, K. F., Rickels, M. R., Ahima, R. S., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2545 · Cited by 197 · see citing works
Resistin- and Obesity-associated Metabolic Diseases
Lazar, M. A. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-985897 · Cited by 194 · see citing works
Gualillo, O., González-Juanatey, J. R., & Lago, F. (2007) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.09.005 · Cited by 193 · see citing works
Pagano, C., Soardo, G., Pilon, C., Milocco, C., Basan, L., Milan, G., Donnini, D., Faggian, D., Mussap, M., Plebani, M., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1056 · Cited by 190 · see citing works
Natural vs Vaccine-Acquired Immunity to Cytomegalovirus—Reply
Schäffler, A., Ehling, A., Neumann, E., Herfarth, H. H., Tarner, I. H., Schölmerich, J., Müller‐Ladner, U., & Gay, S. (2003) · JAMA · doi:10.1001/jama.290.13.1709-c · Cited by 187 · see citing works
Self-citationNagaev, I., Bokarewa, M. I., Tarkowski, A., & Smith, U. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000031 · Cited by 176 · see citing works
Resistin Is Expressed in the Human Placenta
Yura, S., Sagawa, N., Itoh, H., Kakui, K., Nuamah, M. A., Korita, D., 竹村, 真., & Fujii, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-011926 · Cited by 175 · see citing works
Bajaj, M., Suraamornkul, S., Hardies, L. J., Pratipanawatr, T., & DeFronzo, R. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802625 · Cited by 159 · see citing works
Inhibition by insulin of resistin gene expression in 3T3‐L1 adipocytes
Haugen, F., Jørgensen, A., Drevon, C. A., & Trayhurn, P. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02968-4 · Cited by 158 · see citing works
Hogan, S. P., Seidu, L., Blanchard, C., Groschwitz, K. R., Mishra, A., Karow, M. L., Ahrens, R., Artis, D., Murphy, A. J., Valenzuela, D. M., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.039 · Cited by 158 · see citing works
Inflammation of the cystic fibrosis mouse small intestine
Norkina, O., Kaur, S., Ziemer, D. M., & Lisle, R. C. D. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00473.2003 · Cited by 157 · see citing works
Lipopolysaccharide increases resistin gene expression in vivo and in vitro
Lu, S., Shieh, W.-Y., Chen, C.-Y., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03450-6 · Cited by 156 · see citing works
Moon, B. C., Kwan, J. J., Duddy, N., Sweeney, G., & Begum, N. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00457.2002 · Cited by 154 · see citing works
Ghosh, S., Singh, A., Battu, A., Mukhopadhyay, S., & Ehtesham, N. Z. (2003) · Gene · doi:10.1016/s0378-1119(02)01213-1 · Cited by 153 · see citing works
Resistin as an Intrahepatic Cytokine
Bertolani, C., Sancho‐Bru, P., Failli, P., Bataller, R. A., Aleffi, S., DeFranco, R., Mazzinghi, B., Romagnani, P., Milani, S., Ginès, P., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060081 · Cited by 151 · see citing works
Differential Regulation of Adipocytokine mRNAs by Rosiglitazone in db/db Mice
Moore, G. B. T., Chapman, H., Holder, J. C., Lister, C. A., Piercy, V., Smith, S. A., & Clapham, J. C. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5460 · Cited by 150 · see citing works
Resistin is an inflammatory marker of inflammatory bowel disease in humans
Konrad, A., Lehrke, M., Schachinger, V., Seibold, F., Stark, R. G., Ochsenkühn, T., Parhofer, K. G., Göke, B., & Broedl, U. C. (2007) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3282f16251 · Cited by 148 · see citing works
Relationship of Serum Adiponectin and Resistin Levels with Breast Cancer Risk
Kang, J., Yu, B.-Y., & Youn, D. S. (2007) · Journal of Korean Medical Science · doi:10.3346/jkms.2007.22.1.117 · Cited by 146 · see citing works
Mechanisms Regulating Adipocyte Expression of Resistin
Hartman, H. B., Hu, X., Tyler, K. X., Dalal, C. K., & Lazar, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201451200 · Cited by 145 · see citing works
Peng, X.-D., Xie, H., Zhao, Q., Wu, X., Sun, Z., & Liao, E.-Y. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.08.012 · Cited by 136 · see citing works
Relationship between adipokines and manifestations of childhood asthma
Kim, K. W., Shin, Y. H., Lee, K. E., Kim, E. S., Sohn, M. H., & Kim, K. E. (2008) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00690.x · Cited by 128 · see citing works
The Effect of Leptin on Bone - an Evolving Concept of Action
Cirmanová, V., Bayer, M., Stárka, L., & Zajíčková, K. (2008) · Physiological Research · doi:10.33549/physiolres.931499 · Cited by 123 · see citing works
Relationships between human serum resistin, inflammatory markers and insulin resistance
Bo, S., Gambino, R., Pagani, A., Guidi, S., Gentile, L., Cassader, M., & Pagano, G. F. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803037 · Cited by 123 · see citing works
Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status
Felipe, F., Bonet, M. L., Ribot, J., & Palou, A. (2004) · Diabetes · doi:10.2337/diabetes.53.4.882 · Cited by 123 · see citing works
Lee, J. H., Ort, T., Ma, K., et al. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.08.007 · Cited by 121 · see citing works
Hypothalamic resistin induces hepatic insulin resistance
Muse, E. D., Lam, T. K. T., Scherer, P. E., & Rossetti, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30440 · Cited by 119 · see citing works
Pravenec, M., Kazdová, L., Landa, V., Zı́dek, V., Mlejnek, P., Jansa, P., Wang, J., Qi, N., & Kurtz, T. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304869200 · Cited by 119 · see citing works
Serum Adiponectin, Resistin Levels and Non-alcoholic Fatty Liver Disease in Obese Children
Chao Chun, Z. O. U., Liang, L., Fang, H. O. N. G., Jun Feng, F. U., & Zhao, Z. Y. (2005) · Endocrine Journal · doi:10.1507/endocrj.52.519 · Cited by 118 · see citing works
An update on the biology and physiology of resistin
Adeghate, E. A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4083-2 · Cited by 117 · see citing works
Filková, M., Lišková, M., Hulejová, H., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.095737 · Cited by 115 · see citing works
Self-citationCirculating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease
Valentini, L., Wirth, E. K., Schweizer, U., Hengstermann, S., Schaper, L., Koernicke, T., Dietz, E., Norman, K., Büning, C., Winklhofer‐Roob, B. M., et al. (2008) · Nutrition · doi:10.1016/j.nut.2008.07.020 · Cited by 115 · see citing works
Anti-TNF-alpha therapy modulates resistin in patients with rheumatoid arthritis.
González-Gay, M. Á., García‐Unzueta, M. T., González‐Juanatey, C., Miranda-Filloy, J. A., Vázquez-Rodríguez, T. R., Matias, J. M. D., Martin, J. J., Dessein, P. H., & Llorca, J. (2008) · PubMed · Cited by 109 · see citing works
Graveleau, C., Zaha, V. G., Mohajer, A., Banerjee, R. R., Dudley-Rucker, N., Steppan, C. M., Rajala, M. W., Scherer, P. E., Ahima, R. S., Lazar, M. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504008200 · Cited by 107 · see citing works
Resistin is expressed in pancreatic islets
Minn, A. H., Patterson, N. B., Pack, S., Hoffmann, S. C., Gavrilova, O., Vinson, C., Harlan, D. M., & Shalev, A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.061 · Cited by 102 · see citing works
The serum levels of resistin in rheumatoid arthritis patients.
Migita, K., Maeda, Y., Miyashita, T., Kimura, H., Nakamura, M., Ishibashi, H., & Eguchi, K. (2006) · PubMed · Cited by 101 · see citing works
Resistin expression and regulation in mouse pituitary
Morash, B. A., Wilkinson, D. A., Ur, E., & Wilkinson, M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03108-3 · Cited by 100 · see citing works
Identification of RELMγ, a novel resistin-like molecule with a distinct expression pattern☆
Gerstmayer, B., Küsters, D., Gebel, S., Müller, T. H., Miert, E. V., Hofmann, K., & Bosio, A. (2003) · Genomics · doi:10.1016/s0888-7543(03)00070-3 · Cited by 96 · see citing works
Nogueiras, R., Gallego, R., Gualillo, O., Caminos, J. E., García‐Caballero, T., Casanueva, F. F., & Diéguez, C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00708-7 · Cited by 96 · see citing works
Resistin Inhibits Essential Functions of Polymorphonuclear Leukocytes
Cohen, G., Ilic, D., Raupachova, J., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3761 · Cited by 93 · see citing works
Role of resistin as a marker of inflammation in systemic lupus erythematosus
Almehed, K., Forsblad‐d’Elia, H., Bokarewa, M. I., & Carlsten, H. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2366 · Cited by 92 · see citing works
Cardiovascular risk in rheumatoid arthritis: effects of anti-TNF drugs
Avouac, J., & Allanore, Y. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.7.1121 · Cited by 92 · see citing works
Resistin: an adipocyte‐derived hormone. Has it a role in diabetes and obesity?
Rea, R., & Donnelly, R. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00334.x · Cited by 91 · see citing works
Resistin and adiponectin levels in subjects with coronary artery disease and type 2 diabetes
Yaturu, S., Daberry, R. P., Rains, J., & Jain, S. K. (2006) · Cytokine · doi:10.1016/j.cyto.2006.05.005 · Cited by 91 · see citing works
Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines
Corbetta, S., Angioni, R., Cattaneo, A. G., et al. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.02057 · Cited by 90 · see citing works
Plasma Resistin Associated With Myocardium Injury in Patients With Acute Coronary Syndrome
Chu, S., Ding, W., Li, K., et al. (2008) · Circulation Journal · doi:10.1253/circj.72.1249 · Cited by 85 · see citing works
Aquilante, C. L., Kosmiski, L. A., Knutsen, S. D., & Zineh, I. (2008) · Metabolism · doi:10.1016/j.metabol.2007.11.010 · Cited by 83 · see citing works
Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs
Koh, K. K., Quon, M. J., Han, S. H., Lee, Y., Kim, S., Koh, Y., & Shin, E. K. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.11.017 · Cited by 82 · see citing works
Lee, T., Lin, C.-Y., Tsai, J., et al. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.11.004 · Cited by 81 · see citing works
Simone, N. D., Nicuolo, F. D., Sanguinetti, M., et al. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06610 · Cited by 74 · see citing works
Koufany, M., Moulin, D., Bianchi, A., Muresan, M., Sébillaud, S., Netter, P., Weryha, G., & Jouzeau, J. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2354 · Cited by 67 · see citing works
Kushiyama, A., Shojima, N., Ogihara, T., Inukai, K., Sakoda, H., Fujishiro, M., Fukushima, Y., Anai, M., Ono, H., Horike, N., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503065200 · Cited by 66 · see citing works
Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
Song, H., Shojima, N., Sakoda, H., Ogihara, T., Fujishiro, M., Katagiri, H., Anai, M., Onishi, Y., Ono, H., Inukai, K., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02551-2 · Cited by 64 · see citing works
Forsblad‐d’Elia, H., Pullerits, R., Carlsten, H., & Bokarewa, M. I. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken187 · Cited by 61 · see citing works
Resistin worsens cardiac ischaemia-reperfusion injury
Rothwell, S. E., Richards, M., & Pemberton, C. J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.052 · Cited by 59 · see citing works
Κarmiris, K., Κoutroubakis, I. E., Xidakis, C., et al. (2007) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3282202bca · Cited by 57 · see citing works
Battu, A., Ghosh, S., Singh, A., Mande, S. C., Srinivas, V., Chauhan, R., & Ehtesham, N. Z. (2003) · Biochemistry · doi:10.1021/bi034782v · Cited by 57 · see citing works
Pamuk, G. E., Demir, M., Harmandar, F. A., et al. (2006) · PubMed · Cited by 55 · see citing works
Plasma Resistin Levels in Asthmatics as a Marker of Disease State
LaRochelle, J. S., Freiler, J. F., Dice, J. P., & Hagan, L. L. (2007) · Journal of Asthma · doi:10.1080/02770900701495785 · Cited by 54 · see citing works
Janowska, J., Zahorska‐Markiewicz, B., & Olszanecka‐Glinianowicz, M. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.020 · Cited by 50 · see citing works
Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin
Hu, W.-L., Qian, S., & Li, J. (2007) · Cytokine · doi:10.1016/j.cyto.2007.09.011 · Cited by 48 · see citing works
Human resistin promotes macrophage lipid accumulation
Rae, C. J., & Graham, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0187-6 · Cited by 46 · see citing works
Adipokines and treatment with niacin
Westphal, S., Borucki, K., Taneva, E., et al. (2006) · Metabolism · doi:10.1016/j.metabol.2006.07.002 · Cited by 44 · see citing works
Serum Resistin and Hepatic Fat Content in Nondiabetic Individuals
Perseghin, G., Lattuada, G., COBELLI, F. D., Ntali, G., Esposito, A., Burska, A. N., Belloni, E., Canu, T., Ragogna, F., Scifo, P., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1368 · Cited by 44 · see citing works
Schäffler, A., Fürst, A., Büchler, C., Paul, G., Rogler, G., Schölmerich, J., & Herfarth, H. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04300.x · Cited by 42 · see citing works
Circulating resistin concentrations in children depend on renal function
Nüsken, K., Kratzsch, J., Wienholz, V., et al. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfi084 · Cited by 42 · see citing works
von Eynatten, M., Schneider, J. G., Hadziselimovic, S., Hamann, A., Bierhaus, A., Nawroth, P. P., & Dugi, K. A. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.754 · Cited by 41 · see citing works
Salivary resistin reflects local inflammation in Sjögren's syndrome.
Boström, E. A., Forsblad‐d’Elia, H., Dahlgren, U. I., et al. (2008) · PubMed · Cited by 39 · see citing works
Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways
Robertson, S. A., Rae, C. J., & Graham, A. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2008.07.008 · Cited by 35 · see citing works
Biophysical Analyses of Human Resistin: Oligomer Formation Suggests Novel Biological Function
Battu, A., Islam, A., Ghosh, S., et al. (2008) · Biochemistry · doi:10.1021/bi801266k · Cited by 34 · see citing works
Efficacy of Antioxidant Treatment in Reducing Resistin Serum Levels: A Randomized Study
Bo, S., Ciccone, G., Durazzo, M., et al. (2007) · PLoS Clinical Trials · doi:10.1371/journal.pctr.0020017 · Cited by 34 · see citing works
Endothelial dysfunction—An obstacle of therapeutic angiogenesis
Sun, L., Bai, Y., & Du, G. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.04.003 · Cited by 29 · see citing works
Yang, Y., Xiao, M., Mao, Y., Li, H., Zhao, S., Gu, Y., Wang, R., Yu, J., Zhang, X., Irwin, D. M., et al. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.06.033 · Cited by 29 · see citing works
Production and characterization of bioactive recombinant resistin in Escherichia coli
Juan, C., Kan, L.-S., Huang, C., et al. (2003) · Journal of Biotechnology · doi:10.1016/s0168-1656(03)00099-3 · Cited by 25 · see citing works
Resistin induces rat insulinoma cell RINm5F apoptosis
Gao, C., Zhao, D., Qiu, J., Zhang, C., Ji, C., Chen, X.-H., Liu, F., & Guo, X. (2008) · Molecular Biology Reports · doi:10.1007/s11033-008-9371-8 · Cited by 22 · see citing works
Preliminary experience with resistin assessment in common population.
Stejskal, D., Prošková, J., Adamovská, S., et al. (2002) · Biomedical Papers · doi:10.5507/bp.2002.009 · Cited by 21 · see citing works
Obesity in Chronic Kidney Disease: Good or Bad?
Axelsson, J. (2008) · Blood Purification · doi:10.1159/000110559 · Cited by 20 · see citing works
Housa, D., Vernerová, Z., Heráček, J., et al. (2008) · PubMed · Cited by 19 · see citing works
Krušinová, E., Klementová, M., Kopecký, J., et al. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0034 · Cited by 15 · see citing works
Resistin: TWEAKing angiogenesis
Robertson, S. A., Rae, C. J., & Graham, A. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.040 · Cited by 8 · see citing works
Fagerberg, B., Fagerlund, C., & Hulthe, J. (2006) · Kidney International · doi:10.1038/sj.ki.5001583 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): From bench to bedside
Bao, X., Liang, Y., Chang, H., Cai, T., Feng, B., Gordon, K., Zhu, Y., Shi, H., He, Y., & Xie, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01690-3 · Cited by 187 · see citing works
Pathophysiology of NASH: perspectives for a targeted treatment
Marra, F., & Lotersztajn, S. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990344 · Cited by 163 · see citing works
Huang, E. Y., Leone, V. A., Devkota, S., Wang, Y., Brady, M. J., & Chang, E. B. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113486931 · Cited by 133 · see citing works
Vilarrasa, N., Vendrell, J., Maravall, J., Elío, I., Solano, E., San José, P., García, I., Virgili, N., Soler, J., & Gómez, J. M. (2010) · Endocrine · doi:10.1007/s12020-010-9379-4 · Cited by 110 · see citing works
Expanding biology of PCSK9: roles in atherosclerosis and beyond
Seidah, N. G., & Garçon, D. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01057-z · Cited by 76 · see citing works
Bandala, C., Carro-Rodríguez, J., Cárdenas-Rodríguez, N., Peña-Montero, I., Gómez-López, M., Hernández-Roldán, A. P., Huerta-Cruz, J. C., Muñoz-González, F., Ignacio-Mejía, I., Domínguez, B., et al. (2024) · Nutrients · doi:10.3390/nu16142284 · Cited by 18 · see citing works
- Authors
- Filková, M., Haluzík, M., Gay, S., & Šenolt, L.
- Affiliations
- Charles University (CZ)
- University Hospital Zurich (CH)
- Corresponding author
- Šenolt, Ladislav
- Venue
- Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 133
- Issue
- 2
- Pages
- 157-170
- ISSN
- 1521-6616 (ISSN-L)
- OpenAlex
- W2035915584
- Cited by
- 451
- References
- 142
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 47 · 2023: 29 · 2022: 39 · 2021: 40 · 2020: 31 · 2019: 20 · 2018: 26 · 2017: 24 · 2016: 27 · 2015: 27 · 2014: 25 · 2013: 39 · 2012: 20
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- resistin, inflammation, adipokines, mononuclear cells, obesity, subclinical inflammation, atherosclerosis, cardiovascular disease, non-alcoholic fatty liver disease, rheumatic diseases, cancer, asthma, inflammatory bowel disease, chronic kidney disease, insulin resistance, adipose tissue
- MeSH terms
- Animals, Humans, Inflammation, Neoplasms, Obesity, Resistin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review