Non‐dipping Blood Pressure in the Metabolic Syndrome Among Arabs of the Oman Family Study
Open accessAbstract
Objective: The objective was to examine the circadian changes in blood pressure and their relation to the metabolic syndrome and its components in Omani Arabs. Research Methods and Procedures: Ambulatory blood pressure (ABPM) was recorded in 1124 subjects from 5 large, extended, consanguineous, and young Arab pedigrees. According to the International Diabetes Federation's definition, 264 subjects had the metabolic syndrome, a prevalence of 23%. Subjects were defined as non‐dippers when their nocturnal systolic blood pressure (SBP) fell by <10% from daytime SBP. Results: Non‐dippers with the metabolic syndrome were 131 of 264 (50%), compared with 265 of 860 (31%) without the metabolic syndrome. Of the non‐dippers, 99 of 131 (76%) were females and 32 of 131 (24%) were males. Daytime and nighttime SBP and DBP and nighttime pulse pressure were significantly higher in non‐dipper subjects with the metabolic syndrome. The important determinants of a non‐dipping BP in this cohort were high BMI and high serum triglycerides. Discussion: We hypothesize that obesity and nocturnal volume‐dependent hypertension may be involved in the pathophysiology of non‐dipping in the metabolic syndrome. This study showed that non‐dipping BP was common in subjects with the metabolic syndrome. Higher 24‐hour blood pressure load may add to the indices of the overall cardiovascular burden already associated with the metabolic syndrome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nondipping hypertension has been associated with insulin resistance, obesity, the Metabolic Syndrome and type 2 diabetes.
“Nondipping hypertension has been associated with insulin resistance, obesity, the Metabolic Syndrome and type 2 diabetes 64.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
Reaven, G. M., Lithell, H., & Landsberg, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602083340607 · Cited by 1,435 · see citing works
O'Brien, E. T., Sheridan, J., & O'MALLEY, K. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92867-x · Cited by 1,026 · see citing works
Shimada, K., Kawamoto, A., Matsubayashi, K., Nishinaga, M., Kimura, S., & Ozawa, T. (1992) · PubMed · Cited by 454 · see citing works
The metabolic syndrome: requiescat in pace
Reaven, G. M. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.048611 · Cited by 427 · see citing works
The clinical significance of diurnal blood pressure variations. Dippers and nondippers.
Pickering, T. G. (1990) · Circulation · doi:10.1161/01.cir.81.2.700 · Cited by 373 · see citing works
The metabolic syndrome — a neuroendocrine disorder?
Björntorp, P. A., & Rosmond, R. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000957 · Cited by 295 · see citing works
Messerli, F. H. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.141.1.81 · Cited by 281 · see citing works
Impact of Obesity on 24-Hour Ambulatory Blood Pressure and Hypertension
Kotsis, V., Stabouli, S., Bouldin, M., Low, A., Toumanidis, S., & Zakopoulos, N. (2005) · Hypertension · doi:10.1161/01.hyp.0000158261.86674.8e · Cited by 262 · see citing works
Autonomic Nervous Function in Non-dipper Essential Hypertensive Subjects
Kohara, K., Nishida, W., Maguchi, M., & Hiwada, K. (1995) · Hypertension · doi:10.1161/01.hyp.26.5.808 · Cited by 258 · see citing works
Gunderson, E. P., Murtaugh, M. A., Lewis, C. E., Quesenberry, C. P., West, D. S., & Sidney, S. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802551 · Cited by 252 · see citing works
Hoshide, S. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)00567-3 · Cited by 239 · see citing works
Messerli, F. H. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.1981.00340010073016 · Cited by 210 · cited 1× · see citing works
“To our knowledge, only two studies have reported on the redistribution of blood volume in relation to gravity in obese and elderly subjects (27,28).”
BackgroundThe DECODE Study Group, & Qiao, Q. (2006) · Diabetologia · doi:10.1007/s00125-006-0438-6 · Cited by 200 · see citing works
The insulin resistance syndrome
Reaven, G. M. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0007-0 · Cited by 187 · see citing works
Task Force II: Blood pressure measurement and cardiovacular outcome
Staessen, J. A., Asmar, R. G., Buyzere, M. D., Imai, Y., Parati, G., Shimada, K., Stergiou, G. S., Redón, J., & Verdecchia, P. (2001) · Blood Pressure Monitoring · doi:10.1097/00126097-200112000-00016 · Cited by 187 · see citing works
Higashi, Y., Nakagawa, K., Kimura, M., Noma, K., Hara, K., Sasaki, S., Goto, C., Oshima, T., Chayama, K., & Yoshizumi, M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02535-4 · Cited by 161 · see citing works
Liuzzi, A., Savia, G., Tagliaferri, M., Lucantoni, R., Berselli, M. E., Petroni, M. L., Medici, C. D., & Viberti, G. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801036 · Cited by 141 · see citing works
Twenty-four hour ambulatory blood pressure monitoring pattern of resistant hypertension
Muxfeldt, E. S., Bloch, K. V., Nogueira, A. R., & Salles, G. F. (2003) · Blood Pressure Monitoring · doi:10.1097/00126097-200310000-00001 · Cited by 135 · see citing works
Pierdomenico, S. D., Bucci, A., Costantini, F., Lapenna, D., Cuccurullo, F., & Mezzetti, A. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00163-6 · Cited by 116 · see citing works
Langer, S., Scislowski, P. W. D., Brown, D. S., Dewey, P. J. S., & Fuller, M. F. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000088 · Cited by 114 · see citing works
Impact of Visceral Fat on Blood Pressure and Insulin Sensitivity in Hypertensive Obese Women
Faria, A. N., Filho, F. F. R., Ferreira, S. R. G., & Zanella, M. T. (2002) · Obesity Research · doi:10.1038/oby.2002.164 · Cited by 112 · see citing works
Sex, cardiac hypertrophy and diurnal blood pressure variations in essential hypertension
Verdecchia, P., Schillaci, G., Boldrini, F., Guerrieri, M., & Porcellati, C. (1992) · Journal of Hypertension · doi:10.1097/00004872-199207000-00013 · Cited by 99 · see citing works
Role of Insulin Resistance in Nondipper Essential Hypertensive Patients
Anan, F., Takahashi, N., Tatsuhiko, O. O. I. E., Yufu, K., Saikawa, T., & Yoshimatsu, H. (2003) · Hypertension Research · doi:10.1291/hypres.26.669 · Cited by 70 · see citing works
Association of Insulin Resistance With Salt Sensitivity and Nocturnal Fall of Blood Pressure
Suzuki, M., Kimura, Y., Tsushima, M., & Harano, Y. (2000) · Hypertension · doi:10.1161/01.hyp.35.4.864 · Cited by 68 · see citing works
Hojo, Y., Noma, S., Ohki, T., Nakajima, H., & Satoh, Y. (1997) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000515 · Cited by 67 · see citing works
Chen, J., Jen, S.-L., Lee, W.-L., et al. (1998) · Diabetes Care · doi:10.2337/diacare.21.10.1743 · Cited by 65 · see citing works
The spectrum of circadian blood pressure changes in type I diabetic patients
Lurbe, E., Redón, J., Pascual, J. M., Tacons, J., & Álvarez, V. (2001) · Journal of Hypertension · doi:10.1097/00004872-200108000-00010 · Cited by 65 · see citing works
Schmieder, R. E., Rockstroh, J. K., Aepfelbacher, F. C., Schulze, B., & Messerli, F. H. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00364-9 · Cited by 60 · see citing works
Farin, H. M. F., Abbasi, F., & Reaven, G. M. (2005) · Metabolism · doi:10.1016/j.metabol.2005.04.021 · Cited by 51 · see citing works
Physical activity, dipping and haemodynamics
Cavelaars, M., Tulen, J. H. M., van Bemmel, J. H., et al. (2004) · Journal of Hypertension · doi:10.1097/00004872-200412000-00012 · Cited by 47 · see citing works
Matsubara, M., Chiba, H., Maruoka, S., & Katayose, S. (2000) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.7.231 · Cited by 36 · see citing works
Al‐Daghri, N. M., Al‐Rubean, K., Bartlett, W. A., Al‐Attas, O., Jones, A. F., & Kumar, S. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.01044.x · Cited by 34 · see citing works
Metabolic Syndrome as a Predictor of Non-Dipping Hypertension
Tartan, Z., Uyarel, H., Kaşıkçıoğlu, H., Alper, A. T., Özay, B., Bilsel, T., Gül, M., Ozturk, R., & Çam, N. (2006) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.210.57 · Cited by 30 · see citing works
Palatini, P. (2004) · Journal of Hypertension · doi:10.1097/00004872-200412000-00007 · Cited by 30 · see citing works
Effects of Aging on Cardiovascular Responses to Gravity-Related Fluid Shift in Humans
Miwa, C., Sugiyama, Y., Mano, T., et al. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.6.m329 · Cited by 25 · see citing works
A Family Study in Oman: Large, Consanguineous, Polygamous Omani Arab Pedigrees
Hassan, M. O., Albarwani, S., Yahyaee, S. A., Al‐Hadabi, S., Rizwi, S., Jaffer, A. M., Al-Lawati, J. A., Cai, G., Comuzzie, A. G., & Bayoumi, R. (2005) · Public Health Genomics · doi:10.1159/000083341 · Cited by 22 · see citing works
Self-citationO’Brien, E., Mee, F. D., & Atkins, N. (1999) · Blood Pressure Monitoring · doi:10.1097/00126097-199904010-00006 · Cited by 22 · see citing works
Nakano, S., Kitazawa, M., Tsuda, S.-I., Himeno, M., Makiishi, H., Nakagawa, A., Kigoshi, T., & Uchida, K. (2002) · Clinical and Experimental Hypertension · doi:10.1081/ceh-100108716 · Cited by 22 · see citing works
Lyoussi, B., Ragala, M. E. A., M'guil, M., Chraibi, A., & Israili, Z. H. (2005) · Clinical and Experimental Hypertension · doi:10.1081/ceh-57441 · Cited by 17 · see citing works
Influence of obstructive sleep apnoea on circadian blood pressure profile
Pankow, W., Nabe, B., Lies, A., Kohl, F. V., & Lohmann, F. W. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00197.x · Cited by 14 · see citing works
Dippers and non-dippers among overweight hypertensive men.
Chamontin, B., Amar, Garelli-Flores, I. I., et al. (1996) · PubMed · Cited by 11 · see citing works
Left ventricular mass in dippers and non-dippers
Verdecchia, P. (1995) · Journal of Hypertension · doi:10.1097/00004872-199512000-00017 · Cited by 8 · see citing works
Hassan, M. O., Shafie, O. T. A., & Johnston, W. J. (1993) · Clinical Physiology · doi:10.1111/j.1475-097x.1993.tb00467.x · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works
- Authors
- Hassan, M. O., Jaju, D., Albarwani, S., Al‐Yahyaee, S., Al‐Hadabi, S., Lopez‐Alvarenga, J. C., Rizvi, S. G., Comuzzie, A. G., & Bayoumi, R. A.
- Affiliations
- Sultan Qaboos University (OM)
- Ministry of Health (OM)
- Corresponding author
- Hassan, Mohammed O.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2007-10
- Volume
- 15
- Issue
- 10
- Pages
- 2445-2453
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2018782102
- Cited by
- 40
- References
- 44
- Citations by year
- 2024: 4 · 2023: 4 · 2022: 3 · 2021: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- non-dipping blood pressure, circadian blood pressure variation, metabolic syndrome, nocturnal blood pressure, ambulatory blood pressure monitoring, pulse pressure, body mass index, serum triglycerides, nocturnal hypertension, cardiovascular risk
- MeSH terms
- Adult, Blood Pressure, Circadian Rhythm, Consanguinity, Female, Humans, Hypertension, Male, Obesity, Oman, Pedigree, Body Mass Index, Blood Pressure Monitoring, Ambulatory, Arabs, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
