The regulation of acyl-CoA dehydrogenases in adipose tissue by rosiglitazone.
Open accessAbstract
The acyl-CoA dehydrogenases (ACADs), which catalyze the rate-limiting step in the mitochondrial beta-oxidation spiral, were investigated in white adipose tissue (WAT) of C57Bl/6 mice treated with 10 mg/kg/day rosiglitazone. Rosiglitazone was also administered to PPAR-alpha knockout mice. ACAD abundance and activity were determined using western blotting and an ACAD enzyme activity assay. Rosiglitazone increased ACAD activity in both epididymal and inguinal WAT but not in brown adipose tissue, liver, or muscle. Given the known function of PPAR-alpha in regulating the expression of ACAD genes in liver, it was hypothesized that PPAR-alpha may be involved in upregulating the ACADs during rosiglitazone-mediated adipose tissue remodeling. However, the effect of rosiglitazone on adipose tissue ACAD activity was the same in wild-type and PPAR-alpha knockout mice. In conclusion, rosiglitazone increases expression and activity of ACAD enzymes in WAT independently of PPAR-alpha.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Administration of thiazolidinediones induces changes in mitochondrial content and remodeling in white adipocytes concomitantly with an improvement in insulin sensitivity.
“Administration of thiazolidinediones induces changes in mitochondrial content and remodeling in white adipocytes concomitantly with an improvement in insulin sensitivity (170, 173, 177, 190, 194 -198).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [197]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works
Aoyama, T., Peters, J. M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto, T., & Gonzalez, F. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5678 · Cited by 863 · see citing works
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works
Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo
Bogacka, I., Xie, H., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1392 · Cited by 467 · see citing works
Granneman, J. G., Li, P., Zhu, Z., & Lu, Y. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00009.2005 · Cited by 298 · see citing works
Lee, Y. H., Nair, S., Rousseau, E., Allison, D. B., Page, G. P., Tataranni, P. A., Bogardus, C., & Permana, P. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1867-3 · Cited by 265 · see citing works
PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M.-Y., Richardson, C., Witters, L. A., & Unger, R. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182420899 · Cited by 181 · see citing works
Li, P., Zhu, Z., Lu, Y., & Granneman, J. G. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2005 · Cited by 143 · see citing works
Bogacka, I., Ukropcova, B., McNeil, M., Gimble, J. M., & Smith, S. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1024 · Cited by 138 · see citing works
Fluorometric assay of acyl-CoA dehydrogenases in normal and mutant human fibroblasts
Frerman, F. E., & Goodman, S. I. (1985) · Biochemical Medicine · doi:10.1016/0006-2944(85)90124-3 · Cited by 114 · see citing works
Knauf, C., Rieusset, J., Foretz, M., Cani, P. D., Uldry, M., Hosokawa, M., Martinez, E., Bringart, M., Waget, A., Kersten, S., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1536 · Cited by 72 · see citing works
Mohsen, A.-W. A., & Vockley, J. E. (1995) · Gene · doi:10.1016/0378-1119(95)00256-6 · Cited by 45 · see citing works
Walker, C. G., Sugden, M. C., Gibbons, G. F., & Holness, M. J. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0205 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice
Peek, C. B., Affinati, A. H., Ramsey, K. M., Kuo, H.-Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., et al. (2013) · Science · doi:10.1126/science.1243417 · Cited by 658 · see citing works
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works
Bharathi, S. S., Zhang, Y., Mohsen, A.-W. A., Uppala, R., Balasubramani, M., Schreiber, E. M., Uechi, G. T., Beck, M. E., Rardin, M. J., Vockley, J. E., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.510354 · Cited by 179 · see citing works
Chang, E., & Kim, Y. (2017) · Nutrients · doi:10.3390/nu9040338 · Cited by 93 · see citing works
Long-chain Acyl-CoA Dehydrogenase Deficiency as a Cause of Pulmonary Surfactant Dysfunction
Goetzman, E. S., Alcorn, J. F., Bharathi, S. S., Uppala, R., McHugh, K. J., Kośmider, B., Chen, R., Zuo, Y. Y., Beck, M. E., McKinney, R. W., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.540260 · Cited by 51 · see citing works
Aspirin increases mitochondrial fatty acid oxidation
Uppala, R., Dudiak, B. M., Beck, M. E., Bharathi, S. S., Zhang, Y., Stolz, D. B., & Goetzman, E. S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.066 · Cited by 32 · see citing works
White and beige adipocytes: are they metabolically distinct?
Sepa-Kishi, D. M., & Ceddia, R. B. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0003 · Cited by 29 · see citing works
Jeong, Y. S., Hong, J. H., Cho, K. H., & Jung, H. K. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.001 · Cited by 29 · see citing works
Modeling Disorders of Fatty Acid Metabolism in the Mouse
Goetzman, E. S. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-384878-9.00010-8 · Cited by 26 · see citing works
Zhang, Y., Mohsen, A.-W. A., Kochersperger, C., Solo, K. J., Schmidt, A. V., Vockley, J. E., & Goetzman, E. S. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.06.003 · Cited by 18 · see citing works
Forest, C. D., Joffin, N., Jaubert, A., & Noirez, P. (2016) · Adipocyte · doi:10.1080/21623945.2016.1187345 · Cited by 16 · see citing works
Nickel inhibits mitochondrial fatty acid oxidation
Uppala, R., McKinney, R. W., Brant, K. A., Fabisiak, J. P., & Goetzman, E. S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.017 · Cited by 12 · see citing works
Effects of labor on placental fatty acid β oxidation
Figueroa, H. M., Chien, E. K., Ji, H., Nesbitt, N. L., Bharathi, S. S., & Goetzman, E. S. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.722721 · Cited by 12 · see citing works
Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice
Skilling, H., Coen, P. M., Fairfull, L. D., Ferrell, R. E., Goodpaster, B. H., Vockley, J. E., & Goetzman, E. S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.053 · Cited by 7 · see citing works
Ross, R. B., Gadwa, J., Yu, J., Darragh, L. B., Knitz, M. W., Nguyen, D., Olimpo, N. A., Abdelazeem, K. N. M., Nguyen, A. T., Corbo, S., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3433 · Cited by 6 · see citing works
Jiang, A.-A., Li, M., Liu, H. F., Bai, L., Xiao, J., & Li, X. W. (2014) · Genetics and Molecular Research · doi:10.4238/2014.january.22.5 · Cited by 6 · see citing works
Zhu, R., Zou, F., Tian, H., Mo, H., Chen, Q., Zeng, X., Han, S., Shi, D., Shang, J., & Huang, J. (2025) · BMC Genomics · doi:10.1186/s12864-025-11883-5 · Cited by 4 · see citing works
- Authors
- Goetzman, E. S.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Goetzman, Eric S.
- ORCID
- Goetzman, Eric S.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 17
- Issue
- 1
- Pages
- 196-198
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2049082154
- Cited by
- 17
- References
- 13
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- acyl-CoA dehydrogenase, rosiglitazone, white adipose tissue, PPARα, fatty acid beta-oxidation, adipose tissue remodeling, PPARα knockout mice, mitochondrial fatty acid oxidation, thiazolidinediones
- MeSH terms
- Rosiglitazone, Adipose Tissue, Animals, Epididymis, Liver, Male, Mice, Inbred C57BL, Muscle, Skeletal, Acyl-CoA Dehydrogenase, Acyl-CoA Dehydrogenase, Long-Chain, Acyl-CoA Dehydrogenases, Thiazolidinediones, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
