The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents
Open accessAbstract
The aim of this study was to determine the influence of an obesity treatment program on the gut microbiota and body weight of overweight adolescents. Thirty‐six adolescents (13–15 years), classified as overweight according to the International Obesity Task Force BMI criteria, were submitted to a calorie‐restricted diet (10–40%) and increased physical activity (15–23 kcal/kg body weight/week) program over 10 weeks. Gut bacterial groups were analyzed by quantitative real‐time PCR before and after the intervention. A group of subjects (n = 23) experienced >4.0 kg weight loss and showed significant BMI (P = 0.030) and BMI z‐score (P = 0.035) reductions after the intervention, while the other group (n = 13) showed <2.0 kg weight loss. No significant differences in dietary intake were found between both groups. In the whole adolescent population, the intervention led to increased Bacteroides fragilis group (P = 0.001) and Lactobacillus group (P = 0.030) counts, and to decreased Clostridium coccoides group (P = 0.028), Bifidobacterium longum (P = 0.031), and Bifidobacterium adolescentis (P = 0.044) counts. In the high weight–loss group, B. fragilis group and Lactobacillus group counts also increased (P = 0.001 and P = 0.007, respectively), whereas C. coccoides group and B. longum counts decreased (P = 0.001 and P = 0.044, respectively) after the intervention. Total bacteria, B. fragilis group and Clostridium leptum group, and Bifidobacterium catenulatum group counts were significantly higher (P < 0.001–0.036) while levels of C. coccoides group, Lactobacillus group, Bifidobacterium, Bifidobacterium breve, and Bifidobacterium bifidum were significantly lower (P < 0.001–0.008) in the high weight–loss group than in the low weight–loss group before and after the intervention. These findings indicate that calorie restriction and physical activity have an impact on gut microbiota composition related to body weight loss, which also seem to be influenced by the individual's microbiota.
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Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
The gut microbiota as an environmental factor that regulates fat storage
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Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699
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Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792
Dysbiosis of the gut microbiota in disease
Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v26.26191 · Cited by 1,710
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Metadata
- Authors
- Santacruz, A., Marcos, A., Wärnberg, J., Martí, A., Martin‐Matillas, M., Campoy, C., Moreno, L. A., Veiga, O., Redondo‐Figuero, C., Garagorri, J. M., Azcona, C., Delgado, M., García‐Fuentes, M., Collado, M. C., Sanz, Y., & EVASYON Study Group
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-10
- Volume
- 17
- Issue
- 10
- Pages
- 1906-1915
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2030091490
- Cited by
- 476
- References
- 5
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Santacruz, A., Marcos, A., Wärnberg, J., Martí, A., Martin‐Matillas, M., Campoy, C., Moreno, L. A., Veiga, O., Redondo‐Figuero, C., Garagorri, J. M., Azcona, C., Delgado, M., García‐Fuentes, M., Collado, M. C., Sanz, Y., & EVASYON Study Group. (2009). Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents. Obesity. https://doi.org/10.1038/oby.2009.112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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