The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214
Open accessAbstract
Cancer stem cells are responsible for sustaining the tumor and giving rise to proliferating and progressively differentiating cells. However, the molecular mechanisms regulating the process of cancer stem cell (CSC) differentiation is not clearly understood. Recently, we reported the isolation of the epithelial ovarian cancer (EOC) stem cells (type I/CD44+). In this study, we show that type I/CD44+ cells are characterized by low levels of both miR-199a and miR-214, whereas mature EOC cells (type II/CD44−) have higher levels of miR-199a and miR-214. Moreover, these two micro RNAs (miRNAs) are regulated as a cluster on pri-miR-199a2 within the human Dnm3os gene (GenBank FJ623959). This study identify Twist1 as a regulator of this unique miRNA cluster responsible for the regulation of the IKKβ/NF-κB and PTEN/AKT pathways and its association of ovarian CSC differentiation. Our data suggest that Twist1 may be an important regulator of ‘stemness’ in EOC cells. The regulation of MIR199A2/214 expression may be used as a potential therapeutic approach in EOC patients.
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Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 2,060
MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
Papagiannakopoulos, T., Shapiro, A., & Kosik, K. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1305 · Cited by 705
Isolation of differentially expressed genes from wild‐type and Twist mutant mouse limb buds
Loebel, D. A. F., O'Rourke, M. P., Steiner, K. A., Banyer, J., & Tam, P. P. L. (2002) · genesis · doi:10.1002/gene.10091 · Cited by 29
Cited by
miR-214 targets ATF4 to inhibit bone formation
Wang, X., Guo, B., Li, Q., Peng, J., Yang, Z., Wang, A., Li, D., Hou, Z., Lv, K., Kan, G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3026 · Cited by 559
Ma, X., Becker Buscaglia, L. E., Barker, J. R., & Li, Y. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjr007 · Cited by 542
DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer
Lopez-Serra, P., & Esteller, M. (2012) · Oncogene · doi:10.1038/onc.2011.354 · Cited by 360
MicroRNAs, new effectors and regulators of NF‐κB
Boldin, M. P., & Baltimore, D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01089.x · Cited by 199
Rosanò, L., Cianfrocca, R., Spinella, F., Di Castro, V., Nicotra, M. R., Lucidi, A., Ferrandina, G., Natali, P. G., & Bagnato, A. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2325 · Cited by 187
Metadata
- Authors
- Yin, G., Chen, R., Alvero, A. B., Fu, H.-H., Holmberg, J., Glackin, C., Rutherford, T., & Mor, G.
- Venue
- Oncogene
- Published
- 2010-04-19
- Volume
- 29
- Issue
- 24
- Pages
- 3545-3553
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2086677489
- Cited by
- 210
- References
- 3
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Yin, G., Chen, R., Alvero, A. B., Fu, H.-H., Holmberg, J., Glackin, C., Rutherford, T., & Mor, G. (2010). TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Oncogene. https://doi.org/10.1038/onc.2010.111
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