Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells

Bulut, G, Hong, S-H, Chen, K, Beauchamp, E M, Rahim, S, Kosturko, G W, Glasgow, E, Dakshanamurthy, S +5 more·2012·Oncogene
DOI 10.1038/onc.2011.245

Cited by (181)

Items 101–181 of 181

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  13. Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly
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  14. Ezrin is highly expressed and a druggable target in chronic lymphocytic leukemia
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  15. Perspectives for Targeting Ezrin in Cancer Development and Progression
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  16. Microenvironment Signals and Mechanisms in the Regulation of Osteosarcoma
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  17. Role of actin-binding proteins in prostate cancer
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  18. Current Approaches for Personalized Therapy of Soft Tissue Sarcomas
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  20. The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation
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  21. NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells
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  22. Ezrin and Its Phosphorylated Thr567 form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion
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  23. Involvement of intracellular transport in TREK-1c current run-up in 293T cells
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  25. Adenovirus-mediated small interfering RNA targeting ezrin induces apoptosis and inhibits metastasis of human osteosarcoma MG-63 cells
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  26. ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling
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  27. Cell-size-dependent regulation of Ezrin dictates epithelial resilience to stretch by countering myosin-II-mediated contractility
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  28. Gonococcal invasion into epithelial cells depends on both cell polarity and ezrin
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  31. Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion
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  32. A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance
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  33. Hypoxia enhances interactions between Na+/H+ exchanger isoform 1 and actin filaments via ezrin in pulmonary vascular smooth muscle
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  34. Integrative, genome-wide association study identifies chemicals associated with common women's malignancies
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  35. Biological behaviour and ezrin expression in canine rhabdomyosarcomas: 25 cases (1990‐2012)
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  36. Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling
    Giuliana Giamundo, Daniela Intartaglia, Eugenio Del Prete, Elena Polishchuk, Fabrizio Andreone, Marzia Ognibene, Sara Buonocore, Bruno Hay Mele, Francesco Giuseppe Salierno, Jlenia Monfregola et al. · 2025 · eLife
  37. Slp2-a inactivates ezrin by recruiting protein phosphatase 1 to the plasma membrane
    Takao Yasuda, Yuta Homma, Mitsunori Fukuda · 2015 · Biochemical and Biophysical Research Communications
  38. Pan‐Cancer Analysis of Ezrin: A Comprehensive Examination of Its Prognostic Value and Immunological Implications
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  39. Meningococci drive host membrane tubulation to recruit their signaling receptors
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  40. Down-regulation of MRPS23 inhibits LPS-induced proliferation and invasion via regulation of the NF-κB signaling pathway in osteosarcoma cells
    Aiguo Liu, Ke-Lin Xu, Weilin Wang, Bingkang Zhou, Qing-Gong Guo · 2019 · RSC Advances · Retracted
  41. Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis
    Chih-Yuan Chiang, Zhong Hui Yang, Michael D. Ward, Douglas J. Lane, Tara Kenny, Raysa Rosario-Acevedo, Brett Eaton, Sylvia R. Treviño, Taylor B. Chance, Meghan Hu et al. · 2021 · Frontiers in Microbiology
  42. Docking and molecular dynamics studies of human ezrin protein with a modelled SARS-CoV-2 endodomain and their interaction with potential invasion inhibitors
    Selvaa Kumar C, Eleanor ‘Nell’ Watson · 2022 · Journal of King Saud University - Science
  43. Scaffold Hopping and Structural Modification of NSC 663284: Discovery of Potent (Non)Halogenated Aminobenzoquinones
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  44. Inhibition of ezrin phosphorylation by NSC305787 attenuates procaterol-stimulated ciliary beating in airway cilia
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  45. Transcriptomics analysis identified ezrin as a potential druggable target in cervical and gastric cancer cells
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  46. Genetics of Osteosarcomas
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  47. Proteoglycans regulate protein tyrosine phosphatase receptor σ organization on hematopoietic stem/progenitor cells
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  48. ERM proteins: The missing actin linkers in clathrin-mediated endocytosis
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  49. The unphosphorylated, closed form of ezrin binds to RNA to maintain a metastatic phenotype in osteosarcoma cells
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  50. Osteosarcoma as a communication-driven disease: redefining tumor–bone signaling networks as therapeutic targets
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  51. Pharmacological inhibition of ezrin reduces proliferative and invasive phenotype in acute lymphoblastic leukemia cells
    Jean Carlos Lipreri da Silva, Keli Lima, Benjamin C. Ede, Mariana Lazarini, Hugo Passos Vicari, Frederico Lisboa Nogueira, Natasha S. Clayton, Katy Pinnell, Wellington Fernandes da Silva, Elvira Deolinda Rodrigues Pereira Velloso et al. · 2024 · European Journal of Pharmacology
  52. Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
    E. Angelo Morales, Cayetana Arnaiz, Evan Krystofiak, Marija Žanić, Matthew J. Tyska · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Mitotic Spindle Positioning (MISP) is an Actin Bundler that Selectively Stabilizes the Rootlets of Epithelial Microvilli
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  54. Ezrin Thr567 Phosphorylation Participates in Mouse Oocyte Maturation, Fertilization, and Early Embryonic Development
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  55. Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling
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  56. Moesin is Involved in Migration and Phagocytosis Activities of Primary Microglia
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  57. EZR Promotes Pancreatic Cancer Proliferation and Metastasis by Activating FAK/AKT Signaling Pathway
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  58. EZR Promotes Pancreatic Cancer Proliferation and Metastasis by Activating FAK/AKT Signaling Pathway
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  64. Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling
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  65. Inhibiting ezrin triggers formin-mediated actin remodelling reducing cellular mechano-protection
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  66. PHOSPHATIDYLSERINE EXPOSURE AND EXTRACELLULAR ANNEXIN A5 WEAKEN THE ACTIN CORTEX IN OSTEOCLAST FUSION
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  68. Additional file 2 of Identification of key genes as predictive biomarkers for osteosarcoma metastasis using translational bioinformatics
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  69. Additional file 4 of Identification of key genes as predictive biomarkers for osteosarcoma metastasis using translational bioinformatics
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  70. Additional file 1 of EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway
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  71. Additional file 1 of Identification of key genes as predictive biomarkers for osteosarcoma metastasis using translational bioinformatics
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  72. Additional file 3 of Identification of key genes as predictive biomarkers for osteosarcoma metastasis using translational bioinformatics
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  73. From membranes to medicine: Emerging insights into Ezrin’s Role in human disease — A comprehensive overview
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  79. The actomyosin cortex controls t-tubule remodeling in skeletal muscle
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  80. BindingDB Entry 7898: Disorazoles Block Group A Streptococcal Invasion into Epithelial Cells Via Interference with the Host Factor Ezrin.
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  81. BindingDB Entry 50043738: Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma.
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