The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer

Ezponda, T, Popovic, R, Shah, M Y, Martinez-Garcia, E, Zheng, Y, Min, D-J, Will, C, Neri, A +3 more·2013·Oncogene

Cited by (159)

Items 101–159 of 159

  1. MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication
    Debra L. Evans, Haoxing Zhang, Hyoungjun Ham, Huadong Pei, SeungBaek Lee, Jung-Jin Kim, Daniel D. Billadeau, Zhenkun Lou · 2016 · Cell Cycle
  2. NSD2 modulates Drp1-mediated mitochondrial fission in chronic renal allograft interstitial fibrosis by methylating STAT1
    Jianjian Zhang, Weibin Xie, Bing Ni, Zhuohang Li, Dengyuan Feng, Yao Zhang, Qianguang Han, Hai Zhou, Min Gu, Ruoyun Tan · 2024 · Pharmacological Research
  3. The role of transcription factors in laboratory medicine
    Christos K. Kontos, Andreas Scorilas, Athanasios G. Papavassiliou · 2013 · Clinical Chemistry and Laboratory Medicine (CCLM)
  4. Phenotypic Plasticity - Alternate Transcriptional Programs Driving Treatment Resistant Prostate Cancer
    Jagpreet Singh Nanda, Praveen Koganti, Graziela Perri, Leigh Ellis · 2022 · Critical Reviews™ in Oncogenesis
  5. MicroRNA-621 functions as a metastasis suppressor in colorectal cancer by directly targeting LEF1 and suppressing Wnt/β-catenin signaling
    Xinyi Chen, Jingyao Tu, Chaofan Liu, Lu Wang, Xianglin Yuan · 2022 · Life Sciences
  6. NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome
    Amin Sobh, Elena Encinas, Alisha Patel, Greeshma Surapaneni, Emilie Bonilla, Charlotte Leonie Kaestner, Janai Poullard, Monica Clerio, Karthik Vasan, Tzipporah Freeman et al. · 2024 · Blood
  7. Downregulation of MMSET impairs breast cancer proliferation and metastasis through inhibiting Wnt/β-catenin signaling
    Xiaohui Zhao, Tian Xie, Wenhui Zhao, Wanhua Cai, Xiaobo Su · 2019 · OncoTargets and Therapy · Retracted
  8. The epigenetic function of androgen receptor in prostate cancer progression
    Takahiro Sawada, Yoshiaki Kanemoto, Tomohiro Kurokawa, Shigeaki Kato · 2023 · Frontiers in Cell and Developmental Biology
  9. Circ-FOXO3 inhibits triple-negative breast cancer growth and metastasis via regulating WHSC1-H3K36me2-Zeb2 axis
    Danyang Chen, Shanshan Zeng, Huisi Qiu, Mingqiang Yang, Xin Lin, Xinwu Lv, Pan Li, Shaojuan Weng, Siyue Kou, Kai Luo et al. · 2024 · Cellular Signalling
  10. High nuclear expression of Twist1 in the skeletal extramedullary disease of myeloma patients predicts inferior survival
    Jian-Zhu Yang, Weiguang Lian, Lixia Sun, Dianwen Qi, Yang Ding, Xianghong Zhang · 2015 · Pathology - Research and Practice
  11. Epigenetic Modifications in Prostate Cancer Metastasis and Microenvironment
    Shouyi Zhang, Tao Shen, Yu Zeng · 2023 · Cancers
  12. Activating transcription factor 2 promotes the progression of hepatocellular carcinoma by inducing the activation of the WHSC1 ‐mediated TOP2A / PI3K / AKT axis
    Zhongming Bao, Dan Yao, Qian Xu, Hua‐Guo Zhang, Ming Jun Yang, Yun‐Hu Guo, Lei Qin · 2022 · The Kaohsiung Journal of Medical Sciences
  13. WHSC1 acts as a prognostic indicator and functions as an oncogene in cervical cancer
    Jin Wu, Ming Luo, Zhaoning Duan, Ying Jia, Hua Linghu, Pu Tian, Hongbo Qi · 2019 · OncoTargets and Therapy
  14. Chromatin activation with H3K36me2 and compartment shift in metastatic castration-resistant prostate cancer
    Sanji Kanaoka, Atsushi Okabe, Manato Kanesaka, Bahityar Rahmutulla, Masaki Fukuyo, M. Seki, Takayuki Hoshii, Hiroaki Sato, Yusuke Imamura, Shinichi Sakamoto et al. · 2024 · Cancer Letters
  15. Current and Potential Epigenetic Targets in Multiple Myeloma
    Charlotte Pawlyn, Martin Kaiser, Faith E. Davies, Gareth John Morgan · 2014 · Epigenomics
  16. From genomics to functions: preclinical mouse models for understanding oncogenic pathways in prostate cancer.
    Chuan Yu, Kevin M. Hu, Daniel Nguyen, Zhu A. Wang · 2019 · PubMed Central
  17. Epigenetic Regulation of Chromatin in Prostate Cancer
    Ramakrishnan Natesan, Shweta Aras, Samuel Sander Effron, Irfan Ahmed Asangani · 2019 · Advances in experimental medicine and biology
  18. Novel dual-targeting inhibitors of NSD2 and HDAC2 for the treatment of liver cancer: structure-based virtual screening, molecular dynamics simulation, and in vitro and in vivo biological activity evaluations
    Xing Yu Jin, Yuting Wang, Jing Chen, Miaomiao Niu, Yang Yang, Qiaoxuan Zhang, Guangyu Bao · 2023 · Journal of Enzyme Inhibition and Medicinal Chemistry
  19. Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic Carcinoma
    Chao Liu, Yuhang Jiang, Zeliang Zhao, Haiwei Wu, Ling Zhang, Zhijian Yang, Robert M. Hoffman, Jiawei Zheng · 2019 · Anticancer Research
  20. NSD2 is downregulated in T2DM and promotes β cell proliferation and insulin secretion through the transcriptionally regulation of PDX1
    Suqin Shi, Lu Zhao, Lili Zheng · 2018 · Molecular Medicine Reports
  21. Benefits and pitfalls: Epigenetic modulators in prostate cancer intervention
    Neha Upadhyay, Kalpana N. Tilekar, Jessica D. Hess, Vadim S. Pokrovsky, Renato J. Aguilera, C. S. Ramaa · 2021 · Current Research in Chemical Biology
  22. H3 histone methylation landscape in male urogenital cancers: from molecular mechanisms to epigenetic biomarkers and therapeutic targets
    Liliana Burlibaşa, Alina-Teodora Nicu, Mariana Carmen Chifiriuc, Cosmin Medar, Amelia Petrescu, Viorel Jinga, Ileana Stoica · 2023 · Frontiers in Cell and Developmental Biology
  23. Urinary Extracellular Vesicle Signatures as Biomarkers in Prostate Cancer Patients
    Sigrun Lange, Darryl Ethan Bernstein, Nikolay Dimov, Srinivasu Valagerahally Puttaswamy, Ian Johnston, Igor Kraev, Sarah R. Needham, Nikhil Vasdev, Jameel M. Inal · 2025 · International Journal of Molecular Sciences
  24. Association of WHSC1/NSD2 and T-cell infiltration with prostate cancer metastasis and prognosis
    Qiheng Li, Jiang Zhu, Yang Zhang, Yun Pan, Zhengjin Li, Min Wang, Yixuan Gao, Dongmei Feng, Xiaoyong He, Chunmei Zhang · 2023 · Scientific Reports
  25. Recent advances in targeting histone H3 lysine 36 methyltransferases for cancer therapy
    Sai Ma, Guanlu Long, Zheng Jiang, Yan Zhang, Liangkui Sun, Yun Pan, Qidong You, Xiaoke Guo · 2024 · European Journal of Medicinal Chemistry
  26. NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer
    Jia J. Li, Alessandro Vasciaveo, Dimitrios Karagiannis, Zhen Sun, Xiao Chen, Fabio Socciarelli, Ziv Frankenstein, Min Zou, Tania Pannellini, Yu Chen et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic Tumorigenesis
    Wen-Xin Feng, Ning-Ning Niu, Ping Lu, Zhuo Chen, Han-Yu Rao, Wei Zhang, Chunxiao Ma, Changwei Liu, Yue Xu, Wei-Qiang Gao et al. · 2023 · bioRxiv
  28. Role of microRNAs in regulation of WNT signaling pathway in urothelial and prostate cancers
    Mehdi Montazer, Negin Taghehchian, Majid Mojarrad, Meysam Moghbeli · 2022 · Egyptian Journal of Medical Human Genetics
  29. Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities
    Eun-mi Yu, Min Woo Hwang, Jeanny B. Aragon‐Ching · 2023 · Research and Reports in Urology
  30. Epigenetic alterations in prostate cancer: the role of chromatin remodeling
    Md Sadique Hussain, Yumna Khan, Mudasir Maqbool, Gyas Khan, Wedad Mawkili, Faroq Kamli, Ali Hanbashi, Prawez Alam · 2025 · Epigenomics
  31. Multi-Layered Epigenetic Regulatory Mechanisms Mediate Epithelial to Mesenchymal Transition in Cancer
    Tara Boulding Fan Wu · 2014 · Journal of Integrative Oncology
  32. Protein Lysine Methyltransferases Inhibitors
    Ying Li, Lei Ding, Shuang Ren, Wen Zhang, Guo‐Wu Rao · 2022 · Current Medicinal Chemistry
  33. Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate
    Nathan P. Coussens, Stephen C. Kales, Mark J. Henderson, Olivia W. Lee, Kurumi Y. Horiuchi, Yuren Wang, Qing Chen, Ekaterina Kuznetsova, Jianghong Wu, Dorian M. Cheff et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Opposite patterns of association of TWIST1 expression with patient survival in SHH and Group 4 medulloblastoma
    Karina Munhoz de Paula Alves Coelho, Matheus Dalmolin, Francis Rossetti Pedack, José Guilherme Jasper Pickler, Camila Barbosa, Julio Recalde, Rodrigo Blasius, Bruna Louise Silva, Marcelo A. C. Fernandes, Hercílio Fronza et al. · 2025 · Child s Nervous System
  35. Histone-modifying enzymes as drivers and therapeutic targets in androgen-resistant prostate cancer
    Tanaya A. Purohit, Kayla Bahr, Bing Yang, Zachery D. Schultz, Peter W. Lewis, John M. Denu, David Frazier Jarrard · 2026 · Frontiers in Endocrinology
  36. [Exosomes and cancer].
    Jeroen de Vrij, Sybren L. N. Maas, Joost P. Hegmans, Martine L.M. Lamfers, Clemens M.F. Dirven, Marike L. D. Broekman · 2011 · PubMed
  37. Epigenome dysregulation resulting from NSD1 mutation in head and neck squamous cell carcinoma
    Nargess Farhangdoost, Cynthia Horth, Bo Hu, Eric Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, Benjamin A. Garcia, Chao Lü, Jacek Majewski · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  38. NSD Family-Mediated H3K36 Methylation in Human Cancer: Mechanisms and Therapeutic Opportunities
    Jae Eun Park, Minh Tuan Nguyen, Jaehee Kim, Chang Hoon Lee, Jin‐Wu Nam, Heekyoung Chung, Mi Kyung Park, Jeong‐Yeon Lee · 2025 · Biomedicines
  39. Targeting nuclear receptor-binding SET domain protein 2 (NSD2) for cancer therapy: Challenges and emerging strategies
    Zeping Zuo, Junpeng Ran, Yaojia Zhou, Mao Chen · 2025 · Bioorganic Chemistry
  40. A Scalable Platform for Producing Recombinant Nucleosomes with Codified Histone Methyltransferase Substrate Preferences
    Patrick J. McDevitt, Jessica L. Schneck, Elsie Diaz, Wangfang Hou, Michael J. Huddleston, Rosalie Matico, Patricia M. McCormick, Robert B. Kirkpatrick · 2019 · Protein Expression and Purification
  41. The Function of the ASH1L Histone Methyltransferase in Cancer: A Chemical Biology Approach
    David S. Rogawski · 2016 · Deep Blue (University of Michigan)
  42. The Role of Twist1 in Cellular Mechanosensing
    Spencer C. Wei · 2014 · eScholarship (California Digital Library)
  43. Medicinal plants with antioxidant and antiinflammatory properties in cancer prevention
    Paredes González · 2015
  44. Chapter 1 Prostate Cancer: An Introduction
    L. Manendra Babu, Yadu Vijayan, Kuzhuvelil B. Harikumar · 2016 · Traditional herbal medicines for modern times
  45. The role of TWIST1 in multiple myeloma
    Chee Man Cheong · 2017 · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
  46. Genomics and Epigenomics of Prostate Cancer
    Mark A. Rubin, Juan Miguel Mosquera, Pei‐Chun Lin · 2015 · Springer eBooks
  47. Epithelial Plasticity in Castration-Resistant Prostate Cancer: Biology of the Lethal Phenotype
    Andrew J. Armstrong · 2014
  48. Difluoromethyl 2-Pyridyl Sulfone: A Versatile Reagent for the Synthesis of Organofluorine Compounds
    Taige Kong, Jinbo Hu · 2022 · Royal Society of Chemistry eBooks
  49. Circ-FOXO3 inhibits triple-negative breast cancer progression via interaction with WHSC1
    Danyang Chen, Shanshan Zeng, Huisi Qiu, Minqiang Yang, Xin Lin, Xinwu Lv, Pan Li, Shaojuan Weng, Siyue Kou, Kai Luo et al. · 2023 · Research Square
  50. Investigation of NSD2 Protein Expression Changes in Hepatocellular Carcinoma Cells After Treatment With Curcumin and Phthalates
    Seyed Ehsan Alavian, Masoud Salehipour, Saeed Zaker Bostanabad, Farzaneh Tafvizi, Mohammad Heiat · 2023 · International Journal of Medical Toxicology and Forensic Medicine
  51. Clinical Studies and Epi-Drugs in Various Cancer Types
    Taha Bahsi, Ezgi Çevik, Zeynep Tuğba Özdemir, Haktan Bağış Erdem · 2023 · Epigenetics and human health
  52. NSD2 links developmental plasticity to mitochondrial function in muscle and lymphocyte differentiation
    Jorge Martínez-Cano, Ana Sagrera, Belén S. Estrada, Sara Cogliati, Núria Martínez, César Cobaleda · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Synthesis of amide-linked panaxadiol-indolinedione derivatives: A novel NSD2/H3K36me2 epigenetic modulator with significant antitumor efficacy
    Liyan Lv, Tao Li, Mengting Chen, Tonghui Qin, Zhan Wei, Peng Wang, Yuqing Zhao · 2025 · European Journal of Medicinal Chemistry
  54. Unfolding the role of HDAC2 in the epigenetic puzzle of cancer: A dive into molecular pathways for precision-driven multi-target therapy
    Kakali Sarkar, Maria Debbarma, Shayanika Debnath, Sudhan Debnath, Samir Kumar Sil · 2025 · Biochemical Pharmacology
  55. A Pleiotropic Role of the SWI/SNF Complex in Cancer – Insights From Two Tumor Types : Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Prostatic Carcinoma
    Joanna Cyrta · 2020
  56. BindingDB Entry 50020221: Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).
    BindingDB · 2024 · UC San Diego
  57. BindingDB Entry 50020769: Recent advances in nuclear receptor-binding SET domain 2 (NSD2) inhibitors: An update and perspectives.
    BindingDB · 2024 · UC San Diego
  58. BindingDB Entry 50021943: Recent advances in targeting histone H3 lysine 36 methyltransferases for cancer therapy.
    BindingDB · 2025 · UC San Diego
  59. BindingDB Entry 50014111: 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma.
    BindingDB · 2022 · UC San Diego