The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer
Ezponda, T, Popovic, R, Shah, M Y, Martinez-Garcia, E, Zheng, Y, Min, D-J, Will, C, Neri, A +3 more·2013·Oncogene
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- Current and Potential Epigenetic Targets in Multiple MyelomaCharlotte Pawlyn, Martin Kaiser, Faith E. Davies, Gareth John Morgan · 2014 · Epigenomics
- From genomics to functions: preclinical mouse models for understanding oncogenic pathways in prostate cancer.Chuan Yu, Kevin M. Hu, Daniel Nguyen, Zhu A. Wang · 2019 · PubMed Central
- Epigenetic Regulation of Chromatin in Prostate CancerRamakrishnan Natesan, Shweta Aras, Samuel Sander Effron, Irfan Ahmed Asangani · 2019 · Advances in experimental medicine and biology
- Novel dual-targeting inhibitors of NSD2 and HDAC2 for the treatment of liver cancer: structure-based virtual screening, molecular dynamics simulation, and in vitro and in vivo biological activity evaluationsXing Yu Jin, Yuting Wang, Jing Chen, Miaomiao Niu, Yang Yang, Qiaoxuan Zhang, Guangyu Bao · 2023 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic CarcinomaChao Liu, Yuhang Jiang, Zeliang Zhao, Haiwei Wu, Ling Zhang, Zhijian Yang, Robert M. Hoffman, Jiawei Zheng · 2019 · Anticancer Research
- NSD2 is downregulated in T2DM and promotes β cell proliferation and insulin secretion through the transcriptionally regulation of PDX1Suqin Shi, Lu Zhao, Lili Zheng · 2018 · Molecular Medicine Reports
- Benefits and pitfalls: Epigenetic modulators in prostate cancer interventionNeha Upadhyay, Kalpana N. Tilekar, Jessica D. Hess, Vadim S. Pokrovsky, Renato J. Aguilera, C. S. Ramaa · 2021 · Current Research in Chemical Biology
- H3 histone methylation landscape in male urogenital cancers: from molecular mechanisms to epigenetic biomarkers and therapeutic targetsLiliana Burlibaşa, Alina-Teodora Nicu, Mariana Carmen Chifiriuc, Cosmin Medar, Amelia Petrescu, Viorel Jinga, Ileana Stoica · 2023 · Frontiers in Cell and Developmental Biology
- Urinary Extracellular Vesicle Signatures as Biomarkers in Prostate Cancer PatientsSigrun Lange, Darryl Ethan Bernstein, Nikolay Dimov, Srinivasu Valagerahally Puttaswamy, Ian Johnston, Igor Kraev, Sarah R. Needham, Nikhil Vasdev, Jameel M. Inal · 2025 · International Journal of Molecular Sciences
- Association of WHSC1/NSD2 and T-cell infiltration with prostate cancer metastasis and prognosisQiheng Li, Jiang Zhu, Yang Zhang, Yun Pan, Zhengjin Li, Min Wang, Yixuan Gao, Dongmei Feng, Xiaoyong He, Chunmei Zhang · 2023 · Scientific Reports
- Recent advances in targeting histone H3 lysine 36 methyltransferases for cancer therapySai Ma, Guanlu Long, Zheng Jiang, Yan Zhang, Liangkui Sun, Yun Pan, Qidong You, Xiaoke Guo · 2024 · European Journal of Medicinal Chemistry
- NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancerJia J. Li, Alessandro Vasciaveo, Dimitrios Karagiannis, Zhen Sun, Xiao Chen, Fabio Socciarelli, Ziv Frankenstein, Min Zou, Tania Pannellini, Yu Chen et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic TumorigenesisWen-Xin Feng, Ning-Ning Niu, Ping Lu, Zhuo Chen, Han-Yu Rao, Wei Zhang, Chunxiao Ma, Changwei Liu, Yue Xu, Wei-Qiang Gao et al. · 2023 · bioRxiv
- Role of microRNAs in regulation of WNT signaling pathway in urothelial and prostate cancersMehdi Montazer, Negin Taghehchian, Majid Mojarrad, Meysam Moghbeli · 2022 · Egyptian Journal of Medical Human Genetics
- Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic OpportunitiesEun-mi Yu, Min Woo Hwang, Jeanny B. Aragon‐Ching · 2023 · Research and Reports in Urology
- Epigenetic alterations in prostate cancer: the role of chromatin remodelingMd Sadique Hussain, Yumna Khan, Mudasir Maqbool, Gyas Khan, Wedad Mawkili, Faroq Kamli, Ali Hanbashi, Prawez Alam · 2025 · Epigenomics
- Multi-Layered Epigenetic Regulatory Mechanisms Mediate Epithelial to Mesenchymal Transition in CancerTara Boulding Fan Wu · 2014 · Journal of Integrative Oncology
- Protein Lysine Methyltransferases InhibitorsYing Li, Lei Ding, Shuang Ren, Wen Zhang, Guo‐Wu Rao · 2022 · Current Medicinal Chemistry
- Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome SubstrateNathan P. Coussens, Stephen C. Kales, Mark J. Henderson, Olivia W. Lee, Kurumi Y. Horiuchi, Yuren Wang, Qing Chen, Ekaterina Kuznetsova, Jianghong Wu, Dorian M. Cheff et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Opposite patterns of association of TWIST1 expression with patient survival in SHH and Group 4 medulloblastomaKarina Munhoz de Paula Alves Coelho, Matheus Dalmolin, Francis Rossetti Pedack, José Guilherme Jasper Pickler, Camila Barbosa, Julio Recalde, Rodrigo Blasius, Bruna Louise Silva, Marcelo A. C. Fernandes, Hercílio Fronza et al. · 2025 · Child s Nervous System
- Histone-modifying enzymes as drivers and therapeutic targets in androgen-resistant prostate cancerTanaya A. Purohit, Kayla Bahr, Bing Yang, Zachery D. Schultz, Peter W. Lewis, John M. Denu, David Frazier Jarrard · 2026 · Frontiers in Endocrinology
- [Exosomes and cancer].Jeroen de Vrij, Sybren L. N. Maas, Joost P. Hegmans, Martine L.M. Lamfers, Clemens M.F. Dirven, Marike L. D. Broekman · 2011 · PubMed
- Epigenome dysregulation resulting from NSD1 mutation in head and neck squamous cell carcinomaNargess Farhangdoost, Cynthia Horth, Bo Hu, Eric Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, Benjamin A. Garcia, Chao Lü, Jacek Majewski · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- NSD Family-Mediated H3K36 Methylation in Human Cancer: Mechanisms and Therapeutic OpportunitiesJae Eun Park, Minh Tuan Nguyen, Jaehee Kim, Chang Hoon Lee, Jin‐Wu Nam, Heekyoung Chung, Mi Kyung Park, Jeong‐Yeon Lee · 2025 · Biomedicines
- Targeting nuclear receptor-binding SET domain protein 2 (NSD2) for cancer therapy: Challenges and emerging strategiesZeping Zuo, Junpeng Ran, Yaojia Zhou, Mao Chen · 2025 · Bioorganic Chemistry
- A Scalable Platform for Producing Recombinant Nucleosomes with Codified Histone Methyltransferase Substrate PreferencesPatrick J. McDevitt, Jessica L. Schneck, Elsie Diaz, Wangfang Hou, Michael J. Huddleston, Rosalie Matico, Patricia M. McCormick, Robert B. Kirkpatrick · 2019 · Protein Expression and Purification
- The Function of the ASH1L Histone Methyltransferase in Cancer: A Chemical Biology ApproachDavid S. Rogawski · 2016 · Deep Blue (University of Michigan)
- The Role of Twist1 in Cellular MechanosensingSpencer C. Wei · 2014 · eScholarship (California Digital Library)
- Medicinal plants with antioxidant and antiinflammatory properties in cancer preventionParedes González · 2015
- Chapter 1 Prostate Cancer: An IntroductionL. Manendra Babu, Yadu Vijayan, Kuzhuvelil B. Harikumar · 2016 · Traditional herbal medicines for modern times
- The role of TWIST1 in multiple myelomaChee Man Cheong · 2017 · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
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- Difluoromethyl 2-Pyridyl Sulfone: A Versatile Reagent for the Synthesis of Organofluorine CompoundsTaige Kong, Jinbo Hu · 2022 · Royal Society of Chemistry eBooks
- Circ-FOXO3 inhibits triple-negative breast cancer progression via interaction with WHSC1Danyang Chen, Shanshan Zeng, Huisi Qiu, Minqiang Yang, Xin Lin, Xinwu Lv, Pan Li, Shaojuan Weng, Siyue Kou, Kai Luo et al. · 2023 · Research Square
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- Synthesis of amide-linked panaxadiol-indolinedione derivatives: A novel NSD2/H3K36me2 epigenetic modulator with significant antitumor efficacyLiyan Lv, Tao Li, Mengting Chen, Tonghui Qin, Zhan Wei, Peng Wang, Yuqing Zhao · 2025 · European Journal of Medicinal Chemistry
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