Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells

Liu, Z, Li, Q, Li, K, Chen, L, Li, W, Hou, M, Liu, T, Yang, J, Lindvall, C, Björkholm, M, Jia, J, Xu, D·2013·Oncogene

DOI 10.1038/onc.2012.441

Cited by (276)

Items 201–276 of 276

TERT Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival
Sara Gil‐Bernabé, Noa Feás-Rodríguez, Enrique Pérez-Riesgo, Miriam Corraliza-Gómez, J. Fra, Ginesa García‐Rostán · 2025 · Endocrine Pathology
Human telomerase reverse transcriptase (hTERT) synergistic with Sp1 upregulate Gli1 expression and increase gastric cancer invasion and metastasis
Lingyi Wu, Sumin Wang, Bo Tang, Li Tang, Yuanyuan Lei, Yaojiang Liu, Min Yang, Guodong Yang, Dan Zhang, En Liu · 2021 · Journal of Molecular Histology
Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications
Silvia Giunco, Maria Raffaella Petrara, Manuela Zangrossi, Andrea Celeghin, Anita De Rossi · 2018 · Infectious Agents and Cancer
TGF‐β‐mediated regulation of plasminogen activators is human telomerase reverse transcriptase dependent in cancer cells
Rishi Kumar Jaiswal, Pramod Kumar Yadava · 2019 · BioFactors
Helicobacter pylori Induces a Novel NF-kB/LIN28A/let-7a/hTERT Axis to Promote Gastric Carcinogenesis
Shen Li, Jiping Zeng, Lin Ma, Shuyan Li, Chunyan Chen, Jihui Jia, Xiuming Liang · 2020 · Molecular Cancer Research
Epithelial-mesenchymal transition in gastroenterological cancer
Hideo Baba, Hirohisa Okabe, Kosuke Mima, Seiya Saito, Hiromitsu Hayashi, Katsunori Imai, Hidetoshi Nitta, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko et al. · 2015 · Journal of Cancer Metastasis and Treatment
Genetic Variants Associated with Thyroid Cancer Risk: Comprehensive Research Synopsis, Meta-Analysis, and Cumulative Epidemiological Evidence
Ran Ran, Gang Tu, Hui Li, Hao Wang, Exian Mou, Caiyang Liu · 2021 · Journal of Oncology
Telomerase activity: An attractive target for cancer therapeutics
Lucia Picariello · 2014 · World Journal of Pharmacology
Fundamental insights into autosomal dominant polycystic kidney disease from human-based cell models
Caroline Weydert, Jean-Paul Decuypere, Humbert DE SMEDT, Peter Janssens, Rudi Vennekens, Djalila Mekahli · 2018 · Pediatric Nephrology
The TERT copy number gain is sensitive to telomerase inhibitors in human melanoma
Jinyu Yu, Jiayi Yu, Xiaowen Wu, Qian Guo, Ting Yin, Zhiyuan Cheng, Jie Dai, Yan Kong, Jun Guo · 2020 · Clinical Science
Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer
Tomoya Kato, Mikihito Nakamori, Shuichi Matsumura, Masaki Nakamura, Toshiyasu Ojima, Hiroshi Fukuhara, Yasushi Ino, Tomoki Todo, Hiroki Yamaue · 2021 · Oncology Letters · Retracted
Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma
Huiyang Yuan, Xin Qin, Qingya Yang, Li Liu, Zhiqing Fang, Yidong Fan, Dawei Xu · 2023 · Biology of Sex Differences
Therapeutic cancer vaccination against telomerase: clinical developments in melanoma
Espen B. Ellingsen, Jens Bjørheim, Gustav Gaudernack · 2023 · Current Opinion in Oncology
Telomerase inhibition decreases esophageal squamous carcinoma cell migration and invasion
Jiayan Li, Guogang Dong, Jinyun Song, Guolei Tan, Xuping Wu · 2020 · Oncology Letters
Silencing hTERT attenuates cancer stem cell-like characteristics and radioresistance in the radioresistant nasopharyngeal carcinoma cell line CNE-2R
Kai-Hua Chen, Ling Li, Song Qu, Xin‐Bin Pan, Yongchu Sun, Fangzhu Wan, Binbin Yu, Lei Zhou, Xiaodong Zhu · 2020 · Aging
C-MYC as a key effector of WNT, PI3K/AKT, MAPK, and TGF-β signaling pathways in regulation of epithelial-mesenchymal transition during tumor metastasis
Meysam Moghbeli · 2026 · Cancer Cell International
HES1 in cancer: a key player in tumorigenesis and its prognostic significance
Venkataraman Magesh, Ramya Sekar, Abdullah M. Alzahrani, Rajkapoor Balasubramanian, Salaheldin Abdelraouf Abdelsalam, Peramaiyan Rajendran · 2025 · Molecular Genetics and Genomics
[Retracted] Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer
Tomoya Kato, Mikihito Nakamori, Shuichi Matsumura, Masaki Nakamura, Toshiyasu Ojima, Hiroshi Fukuhara, Yasushi Ino, Tomoki Todo, Hiroki Yamaue · 2021 · Oncology Letters · Retracted
Alveolar epithelial-to-mesenchymal transition in scleroderma interstitial lung disease: Technical challenges, available evidence and therapeutic perspectives
Enrico De Lorenzis, Christopher W. Wasson, Francesco Del Galdo · 2023 · Journal of Scleroderma and Related Disorders
The combined signatures of telomere and immune cell landscape provide a prognostic and therapeutic biomarker in glioma
Xu Han, Zihan Yan, Kaiyu Fan, Xueyi Guan, Bohan Hu, Xiang Li, Yunwei Ou, Bing Cui, Lingxuan An, Yaohua Zhang et al. · 2023 · Frontiers in Immunology
The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response
Xu Cao, Chiou Mee Kong, Kanchi Madhu Mathi, Yoon Pin Lim, Valère Cacheux-Rataboul, Xueying Wang · 2014 · BMC Biochemistry
Effects of long‐term exposure to MST‐312 on lung cancer cells tumorigenesis: Role of SHH/GLI‐1 axis
Nícolas Jones Villarinho, Flavia da Cunha Vasconcelos, Luciano Mazzoccoli, Marcela Cristina Robaina, Luciana Santos Pessoa, Pablo Enrique Torres Siqueira, Raquel Ciuvalschi Maia, Diêgo Madureira de Oliveira, Tânia Cristina Leite de Sampaio e Spohr, Giselle Pinto de Faria Lopes · 2022 · Cell Biology International
Centros educativos de calidad
Ramón Pérez Juste, Gregorio Rodríguez Gómez, Catalina Martínez Mediano · 1994 · Dialnet (Universidad de la Rioja)
Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO
Kanpitcha Jiramitmongkon, Pichayanoot Rotkrua, Paisan Khanchaitit, Jiraporn Arunpanichlert, Boonchoy Soontornworajit · 2025 · PLoS ONE
Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer
Paweł Kordowitzki, Szymon Graczyk, Sylvia Mechsner, Jalid Sehouli · 2023 · Aging and Disease
Olovnikov, Telomeres, and Telomerase. Is It Possible to Prolong a Healthy Life?
Yegor E. Yegorov · 2023 · Biochemistry (Moscow)
Identification and validation of telomerase related lncRNAs signature to predict prognosis and tumor immunotherapy response in bladder cancer
Xiaoxu Chen, Zheng Qin, Xiao Ming Zhu, Lili Wang, Changying Li, Haitao Wang · 2023 · Scientific Reports
Cross-talk of Three Molecular Subtypes of Telomere Maintenance Defines Clinical Characteristics and Tumor Microenvironment in Gastric Cancer
Mengpei Yan, Zhijun Zhang, Luyao Wang, Hongxin Huang, Jihuan Wang, Chengjun Zhu, Zheng Li, Zekuan Xu · 2024 · Journal of Cancer
Nano-biomaterials in cancer therapy: Advances in targeting and overcoming cancer stem cell resistance
Marzieh Dehghani, Behnam Hajipour Verdom, Fatemeh Rahimzadeh, Parviz Abdolmaleki · 2025 · ADMET & DMPK
Telomere Maintenance and Oncogenesis
Antonio Torres-Montaner · 2025 · International Journal of Molecular Sciences
The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): A randomized open-label phase 2 study
Paul C. Lorigan, Theresa Michelle Medina, Marta Nyakas, Annemie Rutten, Lynn G. Feun, Charles Lance Cowey, Miranda Payne, Israr Hussain, Timothy Michael Kuzel, Steven J O'Day et al. · 2025 · European Journal of Cancer
Levels of neoangiogenesis factors in pathological tissues of gastric cancer patients
Oleg Ivanovich Kit, Elena Mikhaylovna Frantsiyants, Irina Viktorovna Kaplieva, Yu. A. Gevorkyan, Natalya Vasilievna Soldatkina, Elena Alekseevna Dzhenkova, Nikolay S. Samoylenko, Y.A. Pogorelova · 2019 · Экспериментальная и клиническая гастроэнтерология
Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
Hye-Ran Kim, Choong-Won Seo, Keunje Yoo, Sang Jun Han, Jongwan Kim · 2021 · Osong Public Health and Research Perspectives
TERT gene rearrangement in chordomas and comparison to other TERT-rearranged solid tumors
Ju‐Yoon Yoon, Wei Hong Jiang, Christopher R. Orr, Chase Rushton, Stacey Gargano, Sharon J. Song, Mitul Modi, Bryan A. Hozack, John A. Abraham, Atrayee Basu Mallick et al. · 2021 · Cancer Genetics
Niche Induces Dedifferentiation
Puja Sarkar Aditi Kapoor · 2013 · Journal of Bioanalysis & Biomedicine
Introduction to cancer biology
Mehdi Azizi, Hadi Kokabi, Hassan Dianat‐Moghadam, Mohammad Mehrmohammadi · 2022 · Elsevier eBooks
Zinc Finger E-box binding Homeobox 1 as Prognostic Biomarker and its Correlation with Infiltrating Immune Cells and Telomerase in Lung Cancer
Hye-Ran Kim, Choong-Won Seo, Jongwan Kim · 2022 · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters
SMAR1 suppresses the cancer stem cell population via hTERT repression in colorectal cancer cells
Apoorva Parulekar, Arpankumar Choksi, Nandaraj Taye, Totakura V. S. Kumar, Priyanka Firmal, Gopal C. Kundu, Samit Chattopadhyay · 2021 · The International Journal of Biochemistry & Cell Biology
Simultaneous imaging of telomerase activity and protein tyrosine kinase 7 in living cells during epithelial-mesenchymal transformation via a near-infrared light-activatable nanoprobe
Xiuyan Ren, Xiaopeng Liu, Qi Zhang, Chunguang Yang, Zhang-Run Xu · 2024 · Talanta
Development of 3D Cell-Based Fluorescent Reporter Assay for Screening of Drugs Downregulating Telomerase Reverse Transcriptase
You Li, Fengli Zhang, Zhen Qin, Shang‐Tian Yang · 2025 · Bioengineering
Identification of TMEM115 as a tumor suppressor gene and clinical prognostic factor that influences TERT expression in pancreatic cancer
Yu Sakano, Takahito Ohira, Haruka Ooi, Miyu Murata, Takuki Yagyu, Yuji Nakayama, Tomohiko Sakabe, Teruhisa Sakamoto, Yoshihisa Umekita, Yoshiyuki Fujiwara et al. · 2026 · Scientific Reports
Molecular Biology of the Oral Cancer
Tomonori Sasahira, Hiroki Kuniyasu · 2015 · Springer eBooks
A Novel Liquid Biopsy Strategy to Detect Small Amounts of Cancer Cells Using Cancer-Specific Replication Adenoviruses
Masahiro Takakura, Emi Takata, Toshiyuki Sasagawa · 2020 · Journal of Clinical Medicine
TGF-β Signaling Pathway and Its Therapeutic Role in Cancer
Antonisamy William James, Hilal Mohiuddin Bhat, Shahid Yousuf, Masrat Jan, Muneeb U. Rehman, Shahzada Mudasir Rashid · 2025 · Springer eBooks
Identification of telomere maintenance-driven molecular subtypes in hepatocellular carcinoma: implications for prognosis and targeted therapy via KPNA2
Zhicheng Xu, Hanyu Wang, Haixia Tian, Weijing Wang, Dong Hua · 2025 · Discover Oncology
On the Far Side of Telomeres: The Many Roles of Telomerase in the Acquisition and Retention of Cancer Stemness
Kerem Teralı, Açelya Yılmazer · 2016 · InTech eBooks
Skin Neuroendocrine Neoplasms
Sofia Asioli · 2020 · Springer eBooks
Telomerase reverse transcriptase (TERT) : promoter mutation and novel function in human cancer
Tiantian Liu · 2014 · Figshare
Telomerase mutations and carcinogenesis
Zhiming Cai, XiaoQiang GUO, WeiRen HUANG · 2015 · Chinese Science Bulletin (Chinese Version)
Telomeres and telomerase and their functional applications in myeloproliferative neoplasms and acute myeloid leukemia
Jenny Dahlström · 2016 · Figshare
Patients with delusional and bizarre thinking.
R E Anstett, S R Poole, L Wood · 1984 · PubMed
Interrogating telomerase activity and telomere function through in-flask template evolution
Margaret Pruitt · 2017 · KU ScholarWorks (The University of Kansas)
Expression and role of BORIS/CTCFL in human cancer stem cells
Loredana Alberti · 2014 · IRIS
Aging-related neoplasia
Ana Bela Sarmento‐Ribeiro, Maria Filomena Botelho, Ana Cristina Gonçalves, Joana Barbosa Melo, Mafalda Laranjo, Raquel Alves, Joana Jorge, Ilda Patrícia Ribeiro, Salomé Pires, Ana Margarida Abrantes et al. · 2022 · Elsevier eBooks
Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity
Magalie Dosset, Andrea Castro, Xian Su, Hannah K. Carter, Maurizio Zanetti · 2022 · Interdisciplinary cancer research
Cross-talk between NF-κB and telomerase in cancer: Implications in therapy
Shrey Madeka, Ekta Khattar · 2023 · Elsevier eBooks
Data from Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial
Espen B. Ellingsen, Steven J O'Day, Artur Mezheyeuski, Agnieszka Gromadka, Trevor Clancy, Timothy S. Kristedja, Mohammed M. Milhem, Yousef Zakharia · 2023
Data from Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial
Espen B. Ellingsen, Steven J O'Day, Artur Mezheyeuski, Agnieszka Gromadka, Trevor Clancy, Timothy S. Kristedja, Mohammed M. Milhem, Yousef Zakharia · 2023
Loss of CDH16 expression is a strong independent predictor for lymph node metastasis in Middle Eastern papillary thyroid cancer
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Maha M. Al-Rasheed, Padmanaban Annaiyappanaidu, Nabil Siraj, Maximilian Lennartz, Saif S. Al-Sobhi, Fouad Al‐Dayel, Guido Sauter, Khawla Sami Al-Kuraya · 2023 · Scientific Reports
Hippo Signaling Pathway in Cancer Stem Cell
Wang Shen, Weijian Zhao, Hongting Xu, Xiangqian Xiao · 2023
Olovnikov, telomeres and telomerase. is it possible to prolong a healthy life?
Y. E. Yegorov · 2023 · Biochemistry (Moscow)
A telomere-related gene panel predicts the prognosis and Immune Status in gastric cancer
Dai Zhang, Dingli Song, Yiche Li, Fenfen He, Qian Hao, Yujiao Deng, Si Yang, Hui Zhu Wang, Jianghao Chen, Ting Wang · 2024 · Research Square
Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome
Andres J. Nevarez, Anusorn Mudla, Sabrina A. Diaz, Nan Hao · 2024 · PLoS Computational Biology
The phenomenon of the BRAF and TERTp mutational duet in melanoma and other cancers
Dagmara Rusinek, Aleksandra Pfeifer, Artur Zajkowicz, Karolina Tęcza, Jolanta Pamuła‐Piłat, Anna Malgorzata Czarnecka, Małgorzata Oczko‐Wojciechowska · 2024 · Nowotwory Journal of Oncology
Role of Cancer Stem Cells in Ocular Tumors
Radhika Manukonda, Geeta Kashyap Vemuganti · 2025 · Advances in Ophthalmology and Optometry
Identification of TMEM115 as a tumor suppressor gene through TERT regulation in pancreatic cancer
Hiroyuki Kugoh, Yu Sakano, Takahito Ohira, Haruka Ui, Takuki Yagyu, Tomohiko Sakabe, Teruhisa Sakamoto, Yoshihisa Umekita, Yoshiyuki Fujiwara · 2025 · Research Square
Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera
Grant B. Frost, Yue Liu, Stephen J. Kron, Karl A. Scheidt · 2025 · Bioorganic & Medicinal Chemistry Letters
Calcifying nested stromal-epithelial tumor of the liver: Report of two cases revealing novel WT1 mutation and distinct epigenetic features
Andrea Straková Peteříková, Franco Fedeli, Boris Rychlý, Jiří Soukup, Michael Michal, Petr Martínek, Marián Grendár, Elaheh Mosaieby, Nikola Ptáková, Maryna Slisarenko et al. · 2025 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
Additional file 1 of Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
Ellingsen, Espen Basmo, Gergana Bounova, Iliana Kyriaki Kerzeli, Irantzu Anzar, Donjetë Simnica, Elin Aamdal, Tormod Kyrre Guren, Trevor Clancy, Artur Mezheyeuski, Else Marit Inderberg et al. · 2022 · Figshare
Additional file 1 of Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma
Yuan, Huiyang, Xin Qin, Yang, Qingya, Liu, Li, Fang, Zhiqing, Fan, Yidong, Dawei Xu · 2024 · Figshare
Régulation des cellules initiatrices de tumeurs dans le cancer colorectal par la Progastrine
Julie Giraud · 2013 · theses.fr (ABES)
Role of the xenoreceptor PXR (NR1I2) in colon cancer stem cells drug resistance and tumor relapse
Fatemeh Rajabi · 2015 · theses.fr (ABES)
Maintenance des télomères dans la carcinogenèse hépatique : fonction et transfert vers la clinique
Massih Ningarhari · 2022 · theses.fr (ABES)
Développement d’immunothérapies contre l’antigène de tumeur universel hTERT basées sur différentes stratégies vaccinales
Élodie Pliquet · 2015 · theses.fr (ABES)
Genomic characterisation of rare thoracic tumours
Lise Mangiante · 2021 · theses.fr (ABES)
The impact of chronic exposure to cigarette and waterpipe smoke extracts on telomeres, telomerase, and cancer progression
Daria Azar, Danya Kabbani, Carole Abdel Karim, Reem Akika, Pamela N. Melki, Mario El Hourani, Rola Salman, Farah J. Nassar, Alan Shihadeh, Akram Ghantous et al. · 2026 · Frontiers in Genetics