p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

Bailey, J M, Hendley, A M, Lafaro, K J, Pruski, M A, Jones, N C, Alsina, J, Younes, M, Maitra, A, McAllister, F, Iacobuzio-Donahue, C A, Leach, S D·2016·Oncogene
DOI 10.1038/onc.2015.441

Cited by (153)

Items 101–153 of 153

  1. Global, regional, and national burden of pancreatic cancer from 1990 to 2021, with projections for 25 years: a systematic analysis for the Global Burden of Disease Study 2021
    Qihong Wang, Jiao Liu, Zhuo Yang · 2024 · European Journal of Cancer Prevention
  2. Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer
    Xiaojia Li, Jie He, Keping Xie · 2022 · Cellular Oncology
  3. Ductal obstruction promotes formation of preneoplastic lesions from the pancreatic ductal compartment
    Tao Cheng, Zhiheng Zhang, Ziying Jian, Susanne Raulefs, Anna Melissa Schlitter, Katja Steiger, Nadja Maeritz, Yamin Zhao, Shanshan Shen, Xiaoping Zou et al. · 2018 · International Journal of Cancer
  4. Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis
    Tanvi Vikrant Inamdar, Ferdinand Krannich, Nico Hesselbarth, Atul Verma, Teresa Vauti, Mariami Jasaszwili, Ghanem El Kassem, Jasmine Hillmer, Tom Kaune, Michael Boettcher et al. · 2025 · Gut
  5. Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin
    Kiyoshi Saeki, Ian S. Wood, Wei Wang, Shilpa Patil, Yanping Sun, David F. Schaeffer, Gloria H. Su, Janel L. Kopp · 2024 · Cellular and Molecular Gastroenterology and Hepatology
  6. Identifying cooperating cancer driver genes in individual patients through hypergraph random walk
    Tong Zhang, Shao‐Wu Zhang, Mingyu Xie, Yan Li · 2024 · Journal of Biomedical Informatics
  7. Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival
    Jonathan Villanueva, Lawrence N. Kwong, Teng Han, Salvador Alonso Martinez, Michael T. Shanahan, Matt Kanke, Lukas E. Dow, Charles G. Danko, Praveen Sethupathy · 2022 · BMC Genomics
  8. Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis
    Fan Chen, Yi Han, Jingwu Yue, Hui Zhang, Luyang Tian, Zhifa Cao, Mengwen Zhu, Wenjia Wang, Yan Meng, Liwei An et al. · 2025 · Cell Reports
  9. Cellular Plasticity and Heterogeneity in Pancreatic Regeneration and Malignancy
    2017 · Cancer Cell & Microenvironment
  10. Molecular Mechanisms and Function of the p53 Protein Family Member – p73
    Gerry Melino · 2020 · Biochemistry (Moscow)
  11. Pancreatic Cancer Ductal Cell of Origin Drives CD73-Dependent Generation of Immunosuppressive Adenosine
    Kanchan Singh, Erika Yanil Faraoni, Yulin Dai, Vidhi Chandra, Emily Vucic, Tingting Mills, Melissa A. Pruski, Trent Clark, George Van Buren, Nirav C Thosani et al. · 2021 · SSRN Electronic Journal
  12. Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
    Cathy C. Garcia, Aarthi Venkat, Daniel C. McQuaid, Sherry S. Agabiti, Alexander Tong, Boby Mathew, REBECCA L. CARDONE, Rebecca M. Starble, Christian F. Ruiz, Christy Zheng et al. · 2026 · Nature Communications
  13. Single cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree
    Audrey M. Hendley, Arjun Arkal Rao, Laura Leonhardt, Sudipta Ashe, Jennifer Smith, Simone Giacometti, Xianlu L. Peng, Honglin Jiang, David I. Berrios, Mathias Pawlak et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions
    Eileen S. Carpenter, Ahmed M. Elhossiny, Padma Kadiyala, Jay Li, Jake J. McGue, Brian D. Griffith, Yaqing Zhang, Jacob Edwards, Sarah Nelson, Fatima Lima et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  15. A small-molecule compound cocktail for tumor reprogramming therapy for breast cancer
    Zhenyu Wang, Rui Huang, Jie Kong, Maojia Wang, Hao Yang, Hongli Yan, Hao Hui Chen, Yong Yun Han, Junjian Li · 2025 · International Immunopharmacology
  16. Pancreatic Carcinogenesis
    Valentin Taucher, Johannes Haybaeck · 2017 · Springer eBooks
  17. A shifting adversary: control of pancreatic cancer transcriptomic subtypes
    Charles J. David · 2022 · Journal of Cancer Metastasis and Treatment
  18. Pancreatic plasticity: epigenetic mechanisms and connections to neoplasia
    Charles J. David · 2019 · Journal of Pancreatology
  19. Single-cell analysis of ductal differentiation
    Jason Robert Pitarresi, Anil K. Rustgi · 2021 · Nature Biomedical Engineering
  20. Murine Models for Lineage Tracing Cancer Initiating Cells
    Kanchan Singh, Jennifer M. Bailey · 2022 · Methods in molecular biology
  21. Putting the Cell of Origin for Pancreatic Cancer Into its Proper Context
    Howard C. Crawford · 2019 · Cellular and Molecular Gastroenterology and Hepatology
  22. Faculty Opinions recommendation of EMT subtype influences epithelial plasticity and mode of cell migration.
    Arthur M. Mercurio · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  23. From Tissue Turnover to the Cell of Origin of Pancreatic Cancer
    Bo Kong, Eva Thoma, Christoph W. Michalski · 2023
  24. Defining Roles of Metabolic Reprogramming in Pancreatic Tumorigenesis and Tumor Maintenance
    Barbara Scott Nelson · 2020 · Deep Blue (University of Michigan)
  25. Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles
    Jonathan Villanueva, Lawrence N. Kwong, Teng Han, Salvador Alonso Martinez, Michael T. Shanahan, Matt Kanke, Lukas E. Dow, Charles G. Danko, Praveen Sethupathy · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Faculty Opinions recommendation of Cell of origin influences pancreatic cancer subtype.
    Beatriz Sosa‐Pineda · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  27. GSDME with a moonlighting function in pancreatic ductal adenocarcinoma: a narrative review
    Bo Huang · 2022 · Journal of Pancreatology
  28. Data from CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
    Erika Yanil Faraoni, Kanchan Singh, Vidhi Chandra, Olivereen Le Roux, Yulin Dai, İsmet Şahin, Baylee J. O’Brien, Lincoln N. Strickland, Le Li, Emily Vucic et al. · 2023
  29. Data from Cell of Origin Influences Pancreatic Cancer Subtype
    Brittany M. Flowers, Hang Xu, Abigail S. Mulligan, Kathryn J. Hanson, José Antonio Seoane, Hannes S. Vogel, Christina N. Curtis, Laura DeLong Wood, Laura Donatella Attardi · 2023
  30. Data from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
    Eileen S. Carpenter, Ahmed M. Elhossiny, Padma Kadiyala, Jay Li, Jake J. McGue, Brian D. Griffith, Yaqing Zhang, Jacob Edwards, Sarah Nelson, Fatima Lima et al. · 2023
  31. Data from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
    Eileen S. Carpenter, Ahmed M. Elhossiny, Padma Kadiyala, Jay Li, Jake J. McGue, Brian D. Griffith, Yaqing Zhang, Jacob Edwards, Sarah Nelson, Fatima Lima et al. · 2023
  32. Acvr1b loss increases formation of pancreatic precancerous lesions from acinar and ductal cells of origin
    Kiyoshi Saeki, Ian S. Wood, Wei Chuan K. Wang, Shilpa Patil, Yanping Sun, David F. Schaeffer, Gloria H. Su, Janel L. Kopp · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regeneration
    Coralie Cayron, Dimitra Bozoglou, Amélie V. Villard, Gabriela Reyes‐Castellanos, N Therville, Romain Baer, Silvia Arcucci, Nathalie Naud, Marie Tosolini, Frédéric Pont et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Tumor Immune Microenvironment Differences Associated With Racial Disparities in Pancreatic Cancer
    Zachary Gao, Joseph H. Azar, Derek J. Erstad, Zequn Sun, Harinarayanan Janakiraman, Dongjun Chung, David Lewin, Hyun‐Sung Lee, George Van Buren, William P. Fisher et al. · 2025 · Journal of Surgical Research
  35. Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin
    Ilianna Zoi, Memoona Rajput, Adrián Holguín-Horcajo, Malak Haidar, Davide Brusa, Ken Chu, Jane Xie, Mario A. Shields, Sofia Ferreira, Ben Z. Stanger et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  36. Inner and Outer Determinants of Pancreatic Cancer Stem Cells
    Juan Carlos López-Gil, Diego Navarro, Bruno Sáinz · 2025 · Cancer Heterogeneity and Plasticity
  37. Dietary Fat Content Influences PanIN Progression and Pancreatic Cancer Development in Mice
    Urvinder Kaur Sardarni, Erika Yanil Faraoni, AR Waller, Lincoln N. Strickland, Baylee J. O’Brien, Kelsey A. Klute, Jesse L. Cox, Florencia M. McAllister, Jennifer M. Bailey · 2026 · Cancer Research Communications
  38. Additional file 6 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
    Ma, Zuyi, Li, Zhenchong, Wang, Shujie, Zhou, Zixuan, Liu, Chunsheng, Zhuang, Hongkai, Qi Zhou, Shanzhou Huang, Zhang, Chuanzhao, 侯宝华 · 2022 · Figshare
  39. Additional file 4 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
    Ma, Zuyi, Li, Zhenchong, Wang, Shujie, Zhou, Zixuan, Liu, Chunsheng, Zhuang, Hongkai, Qi Zhou, Shanzhou Huang, Zhang, Chuanzhao, 侯宝华 · 2022 · Figshare
  40. Additional file 7 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
    Ma, Zuyi, Li, Zhenchong, Wang, Shujie, Zhou, Zixuan, Liu, Chunsheng, Zhuang, Hongkai, Qi Zhou, Shanzhou Huang, Zhang, Chuanzhao, 侯宝华 · 2022 · Figshare
  41. Additional file 5 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
    Ma, Zuyi, Li, Zhenchong, Wang, Shujie, Zhou, Zixuan, Liu, Chunsheng, Zhuang, Hongkai, Qi Zhou, Shanzhou Huang, Zhang, Chuanzhao, 侯宝华 · 2022 · Figshare
  42. Additional file 1 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
    Ma, Zuyi, Li, Zhenchong, Wang, Shujie, Zhou, Zixuan, Liu, Chunsheng, Zhuang, Hongkai, Qi Zhou, Shanzhou Huang, Zhang, Chuanzhao, 侯宝华 · 2022 · Figshare
  43. Additional file 2 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
    Ma, Zuyi, Li, Zhenchong, Wang, Shujie, Zhou, Zixuan, Liu, Chunsheng, Zhuang, Hongkai, Qi Zhou, Shanzhou Huang, Zhang, Chuanzhao, 侯宝华 · 2022 · Figshare
  44. Additional file 3 of ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
    Ma, Zuyi, Li, Zhenchong, Wang, Shujie, Zhou, Zixuan, Liu, Chunsheng, Zhuang, Hongkai, Qi Zhou, Shanzhou Huang, Zhang, Chuanzhao, 侯宝华 · 2022 · Figshare
  45. Paligenosis: dual potential of mature cell plasticity in regeneration and tumorigenesis
    Fan Xue, Yue Liang, Yi-Fu Miao, Che Liu, Zhi‐Feng Miao, Zhen-Ning Wang · 2026 · MedScience
  46. Conséquences traductionnelles de la perte de 4E-BP1 dans l'adénocarcinome pancréatique
    David Müller · 2016 · theses.fr (ABES)
  47. Cartographie du phosphoprotéome régulé par les isoformes du PI3K de classe I dans le cancer du pancréas
    Célia Cintas · 2017 · theses.fr (ABES)
  48. The role of Activin signaling pathway in the initiation and progression of pancreatic cancer
    Yajie Zhao · 2019 · theses.fr (ABES)
  49. Effet du TGFβ produit par le microenvironnement sur les tumeurs du pancréas exocrine
    Victoire Cardot‐Ruffino · 2019 · theses.fr (ABES)
  50. Identification et ciblage de dialogues tumeur-stroma impliqués dans l'agressivité de l'adénocarcinome canalaire pancréatique
    Alexia Brunel · 2022 · theses.fr (ABES)
  51. Étude de la tumorigenèse pancréatique des tumeurs intracanalaires papillaires et mucineuses du pancréas (TIPMP)
    Diane Lorenzo · 2024 · theses.fr (ABES)
  52. Focus on the Interactive Cooperation Among Mechanotransduction and Biochemical Processes in Pancreatic Ductal Adenocarcinoma Development and Possible Adjuvant Role of Retinoic Acid for Its Treatment: A Narrative Review
    Sirio Fiorino, Wandong Hong, Dario de Biase, Laura Mastrangelo, Francesca Maccioni, Alfonso Grottesi, Francesca Ambrosi, Luca Pincigher, Federico Lari, Christian Bergamini et al. · 2026 · Cancers
  53. Epigenetic progression of pancreatic cancer to aggressive subtypes involves alternate routes of lineage reprogramming in subtype-intermediate progenitor cells
    Kevin Hawthorne, Jennifer R. Eng, Motoyuki Tsuda, Patrick Joseph Worth, Andrew J. Fields, Colin J. Daniel, Andrew Nishida, Carl Pelz, Ellen M. Langer, Trent Waugh et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)