Leach, Steven D.

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 3,969

A draft map of the human proteome

Kim, M.-S., Pinto, S. M., Getnet, D., Nirujogi, R. S., Manda, S. S., Chaerkady, R., Madugundu, A. K., Kelkar, D. S., Isserlin, R., Jain, S., et al. (2014) · Nature

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 2,198

Organoid models of human and mouse ductal pancreatic cancer

Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 2,150

EMT and Dissemination Precede Pancreatic Tumor Formation

Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell

Cancer Cells and MetastasisPancreatic and Hepatic Oncology Research

Cited by 2,136

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Initiative, A. P. C. G., Balachandran, V. P., Łuksza, M., Zhao, J. N., Makarov, V., Moral, J. A., Remark, R., Herbst, B., Askan, G., Bhanot, U., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersPancreatic and Hepatic Oncology Research

Cited by 1,191

Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Miyamoto, Y., Maitra, A., Ghosh, B., Zechner, U., Argani, P., Iacobuzio-Donahue, C. A., Sriuranpong, V., Iso, T., Meszoely, I. M., Wolfe, M. S., et al. (2003) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchDevelopmental Biology and Gene Regulation

Cited by 643

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

McAllister, F., Bailey, J. M., Alsina, J., Nirschl, C. J., Sharma, R., Fan, H., Rattigan, Y., Roeser, J. C., Lankapalli, R. H., Zhang, H., et al. (2014) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 405

Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates

Means, A. L., Meszoely, I. M., Suzuki, K., Miyamoto, Y., Rustgi, A. K., Coffey, R. J., Wright, C. V. E., Stoffers, D. A., & Leach, S. D. (2005) · Development

Pancreatic and Hepatic Oncology ResearchPancreatic function and diabetes

Cited by 344

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration

Desai, B. M., Oliver-Krasinski, J., De Leon, D. D., Farzad, C., Hong, N., Leach, S. D., & Stoffers, D. A. (2007) · Journal of Clinical Investigation

Pancreatic function and diabetesPancreatic and Hepatic Oncology Research

Cited by 303

α-Ketoglutarate links p53 to cell fate during tumour suppression

Morris, J. P., Yashinskie, J. J., Koche, R., Chandwani, R., Tian, S., Chen, C.-C., Baslan, T., Marinkovic, Z. S., Sánchez-Rivera, F. J., Leach, S. D., et al. (2019) · Nature

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 296

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms

Lowery, M. A., Wong, W., Jordan, E. J., Lee, J. W., Kemel, Y., Vijai, J., Mandelker, D., Zehir, A., Capanu, M., Salo-Mullen, E., et al. (2018) · JNCI: Journal of the National Cancer Institute

Pancreatic and Hepatic Oncology ResearchBRCA gene mutations in cancer

Cited by 224

Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation

Borden, P., Houtz, J., Leach, S. D., & Kuruvilla, R. (2013) · Cell Reports

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 192

Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas

Fendrich, V., Esni, F., Garay, M. V. R., Feldmann, G., Habbe, N., Jensen, J. N., Dor, Y., Stoffers, D., Jensen, J., Leach, S. D., et al. (2008) · Gastroenterology

Hedgehog Signaling Pathway StudiesPancreatic function and diabetes

Cited by 191

p21 Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

Stewart, Z. A., Leach, S. D., & Pietenpol, J. A. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 168

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

Bailey, J. M., Hendley, A. M., Lafaro, K. J., Pruski, M. A., Jones, N. C., Alsina, J., Younes, M., Maitra, A., McAllister, F., Iacobuzio-Donahue, C. A., et al. (2016) · Oncogene

Pancreatic and Hepatic Oncology ResearchCancer-related Molecular Pathways

Cited by 154

EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC

Krishnamoorthy, G. P., Davidson, N. R., Leach, S. D., Zhao, Z., Lowe, S. W., Lee, G., Landa, I., Nagarajah, J., Saqcena, M., Singh, K., et al. (2019) · Cancer Discovery

Thyroid Cancer Diagnosis and TreatmentRNA and protein synthesis mechanisms

Cited by 94

ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer

Huang, Y.-H., Hu, J., Chen, F., Lecomte, N., Basnet, H., David, C. J., Witkin, M. D., Allen, P. J., Leach, S. D., Hollmann, T. J., et al. (2020) · Cancer Discovery

TGF-β signaling in diseasesPancreatic and Hepatic Oncology Research

Cited by 78

Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules

Singh, K., Lin, J., Lecomte, N., Mohan, P., Gokce, A., Sanghvi, V. R., Jiang, M., Grbovic-Huezo, O., Burčul, A., Stark, S. G., et al. (2021) · Cancer Research

RNA and protein synthesis mechanismsPancreatic and Hepatic Oncology Research

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