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Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes

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ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL

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The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth

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Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression

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MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Krüppel-like factor 4 (KLF4)

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CircAGFG1 promotes cervical cancer progression via miR-370-3p/RAF1 signaling

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Krüppel-Like Factor 4 Inhibits Pancreatic Cancer Epithelial-to-Mesenchymal Transition and Metastasis by Down-Regulating Caveolin-1 Expression

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SUV39H1/DNMT3A‐dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development

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Intrinsic and Extrinsic Factors Impacting Cancer Stemness and Tumor Progression

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A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

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Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise

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Cancer stem cells: a target for overcoming therapeutic resistance and relapse

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Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase

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miRNA‑26a‑5p and miR‑26b‑5p inhibit the proliferation of bladder cancer cells by regulating PDCD10

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AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression

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Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma

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New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy

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Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development

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ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4

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Functionalized Caprolactone-Polyethylene Glycol Based Thermo-Responsive Hydrogels of Silibinin for the Treatment of Malignant Melanoma

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EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis

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Krüppel-like factors in tumors: Key regulators and therapeutic avenues

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Activation of EGFR‐KLF4 positive feedback loop results in acquired resistance to sorafenib in hepatocellular carcinoma

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Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma

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Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells

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Disulfiram/Copper Suppresses Cancer Stem Cell Activity in Differentiated Thyroid Cancer Cells by Inhibiting BMI1 Expression

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Single-cell trajectories of melanoma cell resistance to targeted treatment

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Exosome-derived Small RNAs in mouse Sertoli cells inhibit spermatogonial apoptosis

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Sexual dimorphic expression and release of transcription factors in bovine embryos exposed to oxidative stress

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Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer

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E3 ubiquitin ligase PARK2, an inhibitor of melanoma cell growth, is repressed by the oncogenic ERK1/2-ELK1 transcriptional axis

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GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis

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Identification of calmodulin‐like protein 5 as tumor‐suppressor gene silenced during early stage of carcinogenesis in squamous cell carcinoma of uterine cervix

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Glycoprotein non–metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation

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Context-dependent functions of KLF4 in cancers: Could alternative splicing isoforms be the key?

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Glioma cell proliferation is inhibited by miR-342-3p, miR-377/E2F1 signaling pathway

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Cancer stem cells, epigenetics, tumor microenvironment and future therapeutics in cutaneous malignant melanoma: a review

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A pituitary gene network linking vgll3 to regulators of sexual maturation in male Atlantic salmon

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Cell Populations Expressing Stemness-Associated Markers in Vascular Anomalies

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Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis

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KLF4 suppresses anticancer effects of brusatol via transcriptional upregulating NCK2 expression in melanoma

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Systems analysis of barrier molecule and ARNT-related gene expression regulation in melanoma

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E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene

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A Combined Antitumor Strategy Mediated by a New Targeted Nanosystem to Hepatocellular Carcinoma

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DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma

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Kruppel-like factor 4 inhibits non–small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-β1-meidated ERK/JNK/NF-κB signaling pathways

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KLF4: a multifunctional nexus connecting tumor progression and immune regulation

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tRNA-derived fragments as novel potential biomarkers for relapsed/refractory multiple myeloma

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Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear

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Molecular Mechanisms of Tumor Cell Stemness Modulation during Formation of Spheroids

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Exploring the Germline Genetics of In Situ and Invasive Cutaneous Melanoma

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Genomic Landscape of Meningiomas

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Increased Interleukin-10 Expression by the Inhibition of Ca2+-Activated K+ Channel KCa3.1 in CD4+CD25+ Regulatory T Cells in the Recovery Phase in an Inflammatory Bowel Disease Mouse Model

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Krüppel-like Factors 4 and 5 in Colorectal Tumorigenesis

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Looking for Sunshine: Genetic Predisposition to Sun Seeking in 265,000 Individuals of European Ancestry

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Embryonic Stem Cell-like Population in Hypertrophic Port-wine Stain

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ETAR silencing ameliorated neurovascular injury after SAH in rats through ERK/KLF4-mediated phenotypic transformation of smooth muscle cells

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Genome-wide CRISPR knockout screening identified G protein pathway suppressor 2 as a novel tumor suppressor for uveal melanoma metastasis

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A–Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer

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Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma

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Cyanidin-3-O-glucoside inhibits the malignant progression of colorectal cancer by regulating Kruppel-like factor 4-mediated ERK/p38 signaling pathway

Chang, J., & Xiao, G. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117268 · Cited by 6 · see citing works

CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma

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TIPE2 inhibits melanoma progression through MEK/ERK signaling

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Envoplakin Inhibits Macrophage Polarization by Altering the Inflammatory Tumor Microenvironment of Melanoma Through the RAS / ERK Signaling Pathway

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Dual Inhibition of SYK and EGFR Overcomes Chemoresistance by Inhibiting CDC6 and Blocking DNA Replication

Mandal, J., Jones, T. N., Liberto, J. M., Gaillard, S. L., Wang, T., & Shih, I. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0769 · Cited by 5 · see citing works

Spatiotemporal Labeling of Melanocytes in Mice

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A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State

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Impact of Genomic Mutation on Melanoma Immune Microenvironment and IFN-1 Pathway-Driven Therapeutic Responses

Mentucci, F. M., Nuñez, E. A. R., Ercole, A., Silvetti, V., Col, J. D., & Lamberti, M. J. (2024) · Cancers · doi:10.3390/cancers16142568 · Cited by 4 · see citing works

Targeting of S-phase kinase associated protein 2 stabilized tumor suppressors leading to apoptotic cell death in squamous skin cancer cells

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Modulating Cancer Stem Cell Characteristics in CD133+ Melanoma Cells through Hif1α, KLF4, and SHH Silencing

Özdil, B., Avcı, Ç. B., Calik-Kocaturk, D., Gorgulu, V., Uysal, A., Güler, G., Yavaşoğlu, N. Ü. K., & Aktuğ, H. (2025) · ACS Omega · doi:10.1021/acsomega.5c00799 · Cited by 3 · see citing works

The effect of microRNA-9 overexpression on inhibition of melanoma cancer stem cells tumorigenicity

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Association of Inherited Genetic Variants with Multiple Primary Melanoma

Gibbs, D. C., Small, B. M., Autuori, I., Leong, S. F., Ali, E., Kenney, J., Luo, L., Kanetsky, P. A., BUSAM, K. J., Cust, A. E., et al. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-24-1442 · Cited by 3 · see citing works

The hipotises of the immune system's role in carcinogenesis

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TMPRSS11B promotes an acidified microenvironment and immune suppression in squamous lung cancer

Sunil, H. S., Clemenceau, J. R. V., Grichuk, A., Barnfather, I., Nakkireddy, S. R., Izzo, L., Feng, Q., Hartnett, W., Evers, B. M., Thomas, L., et al. (2025) · EMBO Reports · doi:10.1038/s44319-025-00631-1 · Cited by 2 · see citing works

Itraconazole-Induced the Activation of Adenosine 5'-Monophosphate (Amp)-Activated Protein Kinase Inhibits Tumor Growth of Melanoma via Inhibiting ERK Signaling

Fan, N., Sun, Y., Yan, L., Chen, W., Wang, Y., Wang, S., & Song, Y. (2022) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-021-01048-y · Cited by 2 · see citing works

PRMT6 Inhibits Malignant Progression of Melanoma by Antagonizing Trimethylation of Histone H3K4 to Downregulate ALDH1A1 Levels

Cai, M., Wang, L., Sun, M., Liu, M., & Liu, Y. (2025) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.70034 · Cited by 1 · see citing works

Bushen Tiaojing Decoction promotes endometrial angiogenesis to improve endometrial receptivity by regulating KLF4-mediated mitochondrial function and transcription activity

Cao, C., Li, J., Zhang, Y., Wu, S., Liu, Q., Xi, Y., Chen, C., & He, M. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120658 · Cited by 1 · see citing works

ATAD2 drives melanoma growth and progression and inhibits ferroptosis

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Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity

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Shaoyao decoction inhibits neutrophil migration and restores epithelial integrity in ulcerative colitis model mice: insights from single-cell sequencing

Cui, H., Pei, H., Min, F., Wang, Y., Long, Y., Chen, X., Chen, L., Zhou, X., Xing, L., Wen, W., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158737 · Cited by 1 · see citing works

E2F1 rs3213150 polymorphism influences cytarabine sensitivity and prognosis in patients with acute myeloid leukemia

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Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells

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Modulating cancer stem cell characteristics in CD133+ melanoma cells through HIF1α, KLF4, and SHH silencingPreprint

Aktuğ, H., Özdil, B., Avci, Ç. B., Calik-Kocaturk, D., Gorgulu, V., Uysal, A., Güler, G., & Yavaşoğlu, N. Ü. K. (2024) · Research Square · doi:10.21203/rs.3.rs-4808028/v1 · Cited by 1 · see citing works

Downregulation of KLF4 Inhibits Proliferation and Promotes Apoptosis of Melanoma A375 and SK-Mel-28 Cells Through p21/Cyclin D1/E2F1 Signaling Pathway

Zhang, L., Li, Z., Wen, X., Nie, W., Wu, R., & Zhang, G. (2017) · Nanoscience and Nanotechnology Letters · doi:10.1166/nnl.2017.2569

Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesisPreprint

Tran, T. M., Philipp, J., Bassi, J. S., Nibber, N., Draper, J. M., Lin, T. L., Palanichamy, J. K., Jaiswal, A. K., Silva, O., Paing, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.20.423624

Diagnosis of melanocytic neoplasms: a literature review

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Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells

Yu, Y., Tao, M., Xu, L., Cao, L., Le, B., An, N., Dong, J., Xu, Y., Yang, B., Li, W., et al. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0560

Performance of KLF4 and Wnt1 genes expression fluctuations in tumoral and margin tissues of colorectal cancer in an Iranian population

Talebinasab, F., Bandegi, A., Naebi, H., Hemmati, H., Samidoust, P., Delshad, M. S. E., Norollahi, S. E., Vahidi, S., Karimian, P., Najafzadeh, A., et al. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101465

The interplay among MAP3K1 and SOX2 regulated metastasis by MAPK signaling pathway through interaction with KLF4 in triple-negative breast cancerPreprint

Zheng, L., Zheng, X., Ren, X., Hunag, P., Wang, K., Yu, Z., Zeng, M., Liu, T., & Zhou, L. (2021) · Research Square · doi:10.21203/rs.3.rs-927244/v1

Investigation of the role of microtubule dynamics in paracrine signaling and cell invasion in human cancer cells

Pudelko, K. (2021) · doi:10.53846/goediss-8834

Effect of mPFC KLF4 on autism-like behaviors and possible mechanismsPreprint

Ge, T., Zhao, H., Dong, M., Yang, W., Li, B., & Cui, R. (2022) · Research Square · doi:10.21203/rs.3.rs-1728882/v1

Data from Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development

Najm, P., Zhao, P., Steklov, M. Y., Sewduth, R. N., Baietti, M. F., Pandolfi, S., Criem, N., Lechat, B., Maia, T. M., Haver, D. V., et al. (2023) · doi:10.1158/0008-5472.c.6513261.v1

Molecular mechanisms of tumor cell stemness modulation during formation of spheroids: a review

Ponomarev, A. S., Gilazieva, Z., Solovyova, V. V., & Rizvanov, A. A. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523070102

Transmembrane Serine Protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in lung squamous cell carcinomaPreprint

Sunil, H. S., Clemenceau, J. R. V., Barnfather, I., Nakkireddy, S. R., Grichuk, A., Izzo, L., Evers, B. M., Thomas, L. B., Subramaniyan, I., Li, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.01.646727

Additional file 1 of tRNA-derived fragments as novel potential biomarkers for relapsed/refractory multiple myeloma

Xu, C., Liang, T., Zhang, F., Liu, J., & Fu, Y. (2021) · Figshare · doi:10.6084/m9.figshare.14570602

Downregulation of KLF4 Inhibits Proliferation and Promotes Apoptosis of Melanoma A375 and SK-Mel-28 Cells Through p21/Cyclin D1/E2F1 Signaling Pathway

Zhang, L., Li, Z., Wen, X., Nie, W., Wu, R., & Zhang, G. (2017) · Nanoscience and Nanotechnology Letters · doi:10.1166/nnl.2017.2569

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations

Shannon, L., Rauch, J., Walter, K., von Kriegsheim, A., & Rachel, V. (2024) · Veřejné služby Informačního systému (Masarykiana Brunensis Universitas)

AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma

Paudel, R., Goller, S. G., Schwarz, S., Meder, K., Goebeler, M.-E., & Schmidt, M. (2026) · Neoplasia · doi:10.1016/j.neo.2026.101301

ERK5-dependent mechanisms regulate melanoma cell proliferation

Tubita, A. (2019) · Use Siena air (University of Siena)

ERK5 is activated by oncogenic BRAF and promotes melanoma growth

Tusa, I., Gagliardi, S., Tubita, A., Pandolfi, S., Urso, C., Borgognoni, L., Wang, J., Deng, X., Gray, N. S., Stecca, B. A., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0164-9 · Cited by 69 · see citing works