Reference values of regional cerebral oxygen saturation during the first 3 days of life in preterm neonates
Open accessAbstract
Background Currently, reliable reference values of regional cerebral oxygen saturation (rScO2) for different gestational age (GA) groups are lacking, which hampers the implementation of near-infrared spectroscopy (NIRS) alongside monitoring arterial oxygen saturation (SaO2) and blood pressure in neonatal intensive care. The aim of this study was to provide reference values for rScO2 and cerebral fractional tissue oxygen extraction (cFTOE; (SaO2 - rScO2)/SaO2) for small adult and neonatal NIRS sensors.Methods In this study, 999 infants born preterm (GA <32 wk) were monitored with NIRS during the first 72 h of life. Mixed modeling was used to generate reference curves grouped per 2 wk of GA. In addition, the influence of a hemodynamically significant patent ductus arteriosus, gender, and birth weight were explored.Results Average rScO2 was ~65% at admission, increased with GA (1% per week) and followed a parabolic curve in relation to postnatal age with a peak at ~36 h. The cFTOE showed similar but inverse effects. On average, the neonatal sensor measured 10% higher than the adult sensor.Conclusion rScO2 and cFTOE reference curves are provided for the first 72 h of life in preterm infants, which might support the broader implementation of NIRS in neonatal intensive care.
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Average ScO2 values range between approximately 65 and 70% in both term and preterm neonates, in comparison to 46-57% in patients with cyanotic congenital heart disease.
“Average ScO2 values range between approximately 65 and 70% in both term and preterm neonates [68,69], in comparison to 46–57% in patients with cyanotic congenital heart disease [12].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [68]
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References 37 · Cited by 199
Research works printed but not linked: 1
- Hyttel-Sørensen S, Austin T, van Bel F, et al. Clinical use of cere- bral oximetry in extremely preterm infants is feasible. Dan Med J 2013;60:A4533.
- Authors
- Alderliesten, T., Dix, L., Baerts, W., Caicedo, A., van Huffel, S., Naulaers, G., Groenendaal, F., van Bel, F., & Lemmers, P.
- Affiliations
- University Medical Center Utrecht (NL)
- iMinds (BE)
- Universitair Ziekenhuis Leuven (BE)
- Corresponding author
- Alderliesten, Thomas
- Venue
- Pediatric Research
- Published
- 2015-09-21
- Volume
- 79
- Issue
- 1
- Pages
- 55-64
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2257958338
- Cited by
- 199
- References
- 37
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 16 · 2023: 20 · 2022: 31 · 2021: 20 · 2020: 22 · 2019: 19 · 2018: 26 · 2017: 17 · 2016: 6
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- European Commission (2007–2013, 339804, FP7 2007-2013, FP7/2007)
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- regional cerebral oxygen saturation, preterm infants, reference values, near-infrared spectroscopy, gestational age, neonatal intensive care, patent ductus arteriosus, sensor size
- MeSH terms
- Brain Chemistry, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Intensive Care Units, Neonatal, Male, Monitoring, Physiologic, Oximetry, Oxygen, Reference Values, Sex Characteristics, Linear Models, Spectroscopy, Near-Infrared, Body Size
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