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Cited by 55Neonatal and fetal brain pathologyThermal Regulation in MedicineNeuroscience of respiration and sleep

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy

; on behalf of the CoolCap Study Group, Lingappan, Krithika, Kaiser, Jeffrey R., Srinivasan, Chandra, Gunn, Alistair J.·2016·Pediatric Research
DOI 10.1038/pr.2016.62
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Abstract

Background Abnormal PCO2 is common in infants with hypoxic ischemic encephalopathy (HIE). The objective was to determine whether hypocapnia was independently associated with unfavorable outcome (death or severe neurodevelopmental disability at 18 mo) in infants with moderate-to-severe HIE.Methods This was a post hoc analysis of the CoolCap Study in which infants were randomized to head cooling or standard care. Blood gases were measured at prespecified times after randomization. PCO2 and follow-up data were available for 196 of 234 infants. Analyses were performed to investigate the relationship between hypocapnia in the first 72 h after randomization and unfavorable outcome.Results After adjusting for pH, amplitude-integrated electroencephalogram background and seizures, birth weight, Apgar score at 5 min, cooling status, and Sarnat stage, PCO2 was inversely associated with unfavorable outcome (P < 0.001). The probability of unfavorable outcome was 0.20 ± 0.1 (point estimate ± SE), 0.53 ± 0.23 and 0.89 ± 0.16 for a PCO2 of 40, 30, and 20 mm Hg respectively and was greater in infants with severe HIE than with moderate HIE.Conclusions Hypocapnia in infants with moderate-to-severe HIE was independently associated with unfavorable outcome. Future studies of controlled normocapnia will be important.

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Crossref · 10.1038/pr.2016.62

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  • Emerging evidence highlights that factors such as hypocapnia, hyperoxia, extreme fluctuations in blood pressure and glucose are associated with worse outcomes in neonates with HIE.

    “Emerging evidence highlights that factors such as hypocapnia, hyperoxia, extreme fluctuations in blood pressure and glucose are associated with worse outcomes in this population (1, 4–8).”

    From Lab values in neonates with hypoxic ischemic encephalopathy over time during and after therapeutic hypothermia (2026) · cites this paper as [4]

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Metadata

Authors
; on behalf of the CoolCap Study Group, Lingappan, K., Kaiser, J. R., Srinivasan, C., & Gunn, A. J.
Affiliations
  • Baylor College of Medicine (US)
  • University of Auckland (NZ)
Corresponding author
Kaiser, Jeffrey R.
ORCID
Venue
Pediatric Research
Publisher
Springer Science and Business Media LLC
Published
2016-04-06
Volume
80
Issue
2
Pages
204-208
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
DOI
10.1038/pr.2016.62
OpenAlex
W2333542235
Cited by
55
References
25
Citations by year
2026: 4 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 1
FWCI
6.98
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchSpace (University of Auckland) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
hypoxic-ischemic encephalopathy, hypocapnia, arterial PCO2, blood gases, neurodevelopmental outcomes, infant mortality, head cooling, neonatal hypoxia, Sarnat staging, normocapnia
MeSH terms
Apgar Score, Birth Weight, Blood Gas Analysis, Electroencephalography, Female, Humans, Hydrogen-Ion Concentration, Hypothermia, Induced, Infant, Newborn, Male, Oxygen Consumption, Probability, Prognosis, Seizures, Severity of Illness Index, Time Factors, Models, Statistical, Hypocapnia, Treatment Outcome, Hypoxia-Ischemia, Brain, Neurodevelopmental Disorders

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