The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer
Open accessAbstract
Programmed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) pathway blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded clinical benefits in several types of cancer, further studies are required to clarify predictive biomarkers for drug efficacy and to understand the fundamental mechanism of PD-1/PD-L1 interaction between host and tumor cells. Here, we show that exosomes derived from lung cancer cells express PD-L1 and play a role in immune escape by reducing T-cell activity and promoting tumor growth. The abundance of PD-L1 on exosomes represented the quantity of PD-L1 expression on cell surfaces. Exosomes containing PD-L1 inhibited interferon-gamma (IFN-γ) secretion by Jurkat T cells. IFN-γ secretion was restored by PD-L1 knockout or masking on the exosomes. Both forced expression of PD-L1 on cells without PD-L1 and treatment with exosomes containing PD-L1 enhanced tumor growth in vivo. PD-L1 was present on exosomes isolated from the plasma of patients with non-small cell lung cancer, and its abundance in exosomes was correlated with PD-L1 positivity in tumor tissues. Exosomes can impair immune functions by reducing cytokine production and inducing apoptosis in CD8+T cells. Our findings indicate that tumor-derived exosomes expressing PD-L1 may be an important mediator of tumor immune escape.
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Cites
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Cited by
The importance of exosomal PDL1 in tumour immune evasion
Daassi, D., Mahoney, K. M., & Freeman, G. J. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0264-y · Cited by 598
The crosstalk: exosomes and lipid metabolism
Wang, W., Zhu, N., Yan, T., Shi, Y.-N., Chen, J., Zhang, C.-J., Xie, X.-J., Liao, D.-F., & Qin, L. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00581-2 · Cited by 203
Exosomal PD‐L1: New Insights Into Tumor Immune Escape Mechanisms and Therapeutic Strategies
Zhou, K., Guo, S., Li, F., Sun, Q., & Liang, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.569219 · Cited by 99
“Moreover, PD-L2 not only possesses higher affinity for PD-1 than PD-L1 does but also may be highly coexpressed with PD-L1 in tumor cells and tissues (Youngnak et al., 2003; Cheng et al., 2013; Morales-Betanzos et al., 2017; Tang and Kim, 2019; Furuse et al., 2020; Wolkow et al., 2020).”
BackgroundLiu, J., Peng, X., Yang, S., Li, X., Huang, M., Wei, S., Zhang, S., He, G., Zheng, H., Fan, Q., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-021-00816-w · Cited by 75
Liu, Y., Xia, Y., Smollar, J., Mao, W., & Wan, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188539 · Cited by 23
Metadata
- Authors
- Kim, D. H., Kim, H., Choi, Y. J., Kim, S. Y., Lee, J.-E., Sung, K. J., Sung, Y. H., Pack, C.-G., Jung, M.-K., Han, B., Kim, K., Kim, W. S., Nam, S. J., Choi, C.-M., Yun, M., Lee, J. C., & Rho, J. K.
- Venue
- Experimental & Molecular Medicine
- Published
- 2019-08
- Volume
- 51
- Issue
- 8
- Pages
- 1-13
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W2967202427
- Cited by
- 374
- References
- 9
- FWCI
- 17.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kim, D. H., Kim, H., Choi, Y. J., Kim, S. Y., Lee, J.-E., Sung, K. J., Sung, Y. H., Pack, C.-G., Jung, M.-K., Han, B., Kim, K., Kim, W. S., Nam, S. J., Choi, C.-M., Yun, M., Lee, J. C., & Rho, J. K. (2019). Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer. Experimental & Molecular Medicine. https://doi.org/10.1038/s12276-019-0295-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
