Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
Abstract
Normal and malignant cells shed from their surface membranes as well as secrete from the endosomal membrane compartment circular membrane fragments called microvesicles (MV). MV that are released from viable cells are usually smaller in size compared to the apoptotic bodies derived from damaged cells and unlike them do not contain fragmented DNA. Growing experimental evidence indicates that MV are an underappreciated component of the cell environment and play an important pleiotropic role in many biological processes. Generally, MV are enriched in various bioactive molecules and may (i) directly stimulate cells as a kind of 'signaling complex', (ii) transfer membrane receptors, proteins, mRNA and organelles (e.g., mitochondria) between cells and finally (iii) deliver infectious agents into cells (e.g., human immuno deficiency virus, prions). In this review, we discuss the pleiotropic effects of MV that are important for communication between cells, as well as the role of MV in carcinogenesis, coagulation, immune responses and modulation of susceptibility/infectability of cells to retroviruses or prions.
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Extracellular vesicles are membrane fragments shed from cell surfaces to transfer cytoplasmic or membrane contents to neighboring cells or body fluids.
“Extracellular vesicles (Evs) are membrane fragments shed from cell surfaces to transfer cytoplasmic or membrane contents to neighboring cells or body fluids.”
From Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma (2019) · cites this paper as [5]
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- Authors
- Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A., & Ratajczak, M. Z.
- Affiliations
- University of Louisville (US)
- Corresponding author
- Ratajczak, M Z
- Venue
- Leukemia
- Published
- 2006-07-20
- Volume
- 20
- Issue
- 9
- Pages
- 1487-1495
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2086275775
- Cited by
- 1,340
- References
- 1
- Citations by year
- 2026: 21 · 2025: 30 · 2024: 56 · 2023: 59 · 2022: 74 · 2021: 88 · 2020: 86 · 2019: 89 · 2018: 88 · 2017: 101 · 2016: 110 · 2015: 92 · 2014: 86 · 2013: 83 · 2012: 87
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca106281-05)
- Canadian Institutes of Health Research
- National Cancer Institute (R01 CA106281-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- exosomes, cell-to-cell communication, mRNA transfer, organelle transfer, HIV infection, prion infection, carcinogenesis, coagulation, immune response
- MeSH terms
- Cell Communication, Cell Membrane, Humans, Neoplasms, Organelles, Disease Progression
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