The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
COVID-19 and the role of chronic inflammation in patients with obesity
Open accessAbstract
Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Risk stratification based on the Edmonton Obesity Staging System (EOSS), which classifies obesity based on the presence of medical, mental, and/or functional complications rather than on body mass index (BMI), has been shown to be a better predictor of all-cause mortality and it may well be that EOSS stages may better describe the risk of hyperinflammation in patients with COVID-19 infection. Analyzing a group of metabolic ill patients with obesity (EOSS 2 and 3), we found an increased interleukin-6 and linear regression analysis showed a positive correlation with C-reactive protein (CRP) ( p = 0.014) and waist-to-hip-ratio (WHR) ( p = 0.031). Physicians should be aware of these findings in patients with COVID-19 infection. Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality.
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Cites
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Self-citationComorbidities and multi-organ injuries in the treatment of COVID-19
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Cited by
Obesity in patients with COVID-19: a systematic review and meta-analysis
Huang, Y., Lu, Y., Huang, Y.-M., Wang, M., Ling, W., Sui, Y., & Zhao, H.-L. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154378 · Cited by 454
Bektas, A., Schurman, S. H., Franceschi, C., & Ferrucci, L. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00196-8 · Cited by 102
Public Health and Clinical Implications of Nutrition-Infection Interactions
Vermund, S. H., Scott, M. E., & Humphries, D. L. (2021) · Nutrition and Infectious Diseases · doi:10.1007/978-3-030-56913-6_16 · Cited by 5
Metadata
- Authors
- Chiappetta, S., Sharma, A. M., Bottino, V., & Stier, C.
- Venue
- International Journal of Obesity
- Published
- 2020-05-14
- Volume
- 44
- Issue
- 8
- Pages
- 1790-1792
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W3025531395
- Cited by
- 259
- References
- 22
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chiappetta, S., Sharma, A. M., Bottino, V., & Stier, C. (2020). COVID-19 and the role of chronic inflammation in patients with obesity. International Journal of Obesity. https://doi.org/10.1038/s41366-020-0597-4
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