Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia
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Abstract Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the development of acute myeloid leukemia (AML), we compared the nuclear proteome and transcriptome of AML blasts with normal human CD34 + cells. Analysis of the proteome identified networks and processes that significantly affected transcription regulation including misexpression of 11 transcription factors with seven proteins not previously implicated in AML. Transcriptome analysis identified changes in 40 transcription factors but none of these were predictive of changes at the protein level. The highest differentially expressed protein in AML nuclei compared with normal CD34 + nuclei (not previously implicated in AML) was S100A4. In an extended cohort, we found that over-expression of nuclear S100A4 was highly prevalent in AML (83%; 20/24 AML patients). Knock down of S100A4 in AML cell lines strongly impacted their survival whilst normal hemopoietic stem progenitor cells were unaffected. These data are the first analysis of the nuclear proteome in AML and have identified changes in transcription factor expression or regulation of transcription that would not have been seen at the mRNA level. These data also suggest that S100A4 is essential for AML survival and could be a therapeutic target in AML.
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A prior study found altered expression of 13 hnRNPs involved in mRNA processing in AML.
“A recent study reported expression changes in 13 hnRNPs affecting mRNA processing in AML (39), among which hnRNP A1, A2B1, and C were predicted to bind to the NOCIVA junction site.”
From Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias (2021) · cites this paper as [39]
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- Authors
- Alanazi, B., Munje, C. R., Rastogi, N., Williamson, A. J. K., Taylor, S., Hole, P. S., Hodges, M., Doyle, M., Baker, S., Gilkes, A. F., Knapper, S., Pierce, A., Whetton, A. D., Darley, R. L., & Tonks, A.
- Affiliations
- Cardiff University (GB)
- University of Glasgow (GB)
- University of Manchester (GB)
- Corresponding author
- Tonks, Alex
- ORCID
- Venue
- Leukemia
- Published
- 2019-10-14
- Volume
- 34
- Issue
- 2
- Pages
- 427-440
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- PMC
- PMC6995695
- OpenAlex
- W2979936029
- Cited by
- 64
- References
- 78
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 14 · 2020: 5
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Leukemia (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- Prince Mohammed Medical City, Al-Jouf, Saudi Arabia
- EC | European Regional Development Fund - Welsh Government
- Bloodwise (13029, 13005)
- RCUK | Medical Research Council
- Cancer Research UK
- Manchester Experimental Cancer Medicine Centre and NIHR Manchester Biomedical Research Centre
- Health and Care Research Wales
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- acute myeloid leukemia, S100A4, nuclear proteome, nuclear transcriptome, transcription factors, transcriptional regulation, protein mislocalization, therapeutic target, CD34+ cells, leukemia cell survival, gene knockdown
- MeSH terms
- S100 Calcium-Binding Protein A4, Adolescent, Adult, Aged, Cell Nucleus, Cells, Cultured, Female, Humans, Male, Middle Aged, Neoplastic Stem Cells, Leukemia, Myeloid, Acute, Antigens, CD34, Proteome, Proteomics, Cell Proliferation, Transcriptome
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