Cited by 129Circadian rhythm and melatoninImpact of Light on Environment and HealthSleep and Wakefulness Research

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Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior

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Walker, William H., Borniger, Jeremy C., Gaudier-Diaz, Monica M., Hecmarie Meléndez-Fernández, O., Pascoe, Jordan L., Courtney DeVries, A., Nelson, Randy J.·2020·Molecular Psychiatry

DOI 10.1038/s41380-019-0430-4PMC PMC6881534

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Abstract

The advent and wide-spread adoption of electric lighting over the past century has profoundly affected the circadian organization of physiology and behavior for many individuals in industrialized nations; electric lighting in homes, work environments, and public areas have extended daytime activities into the evening, thus, increasing night-time exposure to light. Although initially assumed to be innocuous, chronic exposure to light at night (LAN) is now associated with increased incidence of cancer, metabolic disorders, and affective problems in humans. However, little is known about potential acute effects of LAN. To determine whether acute exposure to low-level LAN alters brain function, adult male, and female mice were housed in either light days and dark nights (LD; 14 h of 150 lux:10 h of 0 lux) or light days and low level light at night (LAN; 14 h of 150 lux:10 h of 5 lux). Mice exposed to LAN on three consecutive nights increased depressive-like responses compared to mice housed in dark nights. In addition, female mice exposed to LAN increased central tendency in the open field. LAN was associated with reduced hippocampal vascular endothelial growth factor-A (VEGF-A) in both male and female mice, as well as increased VEGFR1 and interleukin-1β mRNA expression in females, and reduced brain derived neurotrophic factor mRNA in males. Further, LAN significantly altered circadian rhythms (activity and temperature) and circadian gene expression in female and male mice, respectively. Altogether, this study demonstrates that acute exposure to LAN alters brain physiology and can be detrimental to well-being in otherwise healthy individuals.

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Show all 79 references

Research works printed but not linked: 1

Fonken LK, Kitsmiller E, Smale L, Nelson RJ. Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent. J Biol Rhythms. 2012;27:319–27. · DOI · Paper page

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Authors: Walker, W. H., Borniger, J. C., Gaudier-Diaz, M. M., Hecmarie Meléndez-Fernández, O., Pascoe, J. L., Courtney DeVries, A., & Nelson, R. J.
Affiliations: West Virginia University (US)
The Ohio State University Wexner Medical Center (US)
Corresponding author: Walker, William H.
ORCID: Walker, William H.
Borniger, Jeremy C.
Gaudier-Diaz, Monica M.
Nelson, Randy J.
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2019-05-28
Volume: 25
Issue: 5
Pages: 1080-1093
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/s41380-019-0430-4
PMC: PMC6881534
OpenAlex: W2947169552
Cited by: 129
References: 79
Citations by year: 2026: 15 · 2025: 14 · 2024: 19 · 2023: 23 · 2022: 19 · 2021: 9 · 2020: 30
FWCI: 8.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
Funders: U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS092388)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: light at night, depression-like behavior, circadian rhythm, circadian gene expression, hippocampus, VEGF-A, VEGFR1, IL-1β, brain-derived neurotrophic factor, sex differences, electric lighting, sleep-wake behavior, body temperature rhythm
MeSH terms: Animals, Circadian Rhythm, Depression, Female, Hippocampus, Light, Lighting, Male, Brain-Derived Neurotrophic Factor, Vascular Endothelial Growth Factor A, Mice, Interleukin-1beta

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Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior

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