Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent
Open accessAbstract
Circadian disruption is a common by-product of modern life. Although jet lag and shift work are well-documented challenges to circadian organization, many more subtle environmental changes cause circadian disruption. For example, frequent fluctuations in the timing of the sleep/wake schedule, as well as exposure to nighttime lighting, likely affect the circadian system. Most studies of these effects have focused on nocturnal rodents, which are very different from diurnal species with respect to their patterns of light exposure and the effects that light can have on their activity. Thus, the authors investigated the effect of nighttime light on behavior and the brain of a diurnal rodent, the Nile grass rat. Following 3 weeks of exposure to standard light/dark (LD; 14:10 light [~150 lux] /dark [0 lux]) or dim light at night (dLAN; 14:10 light [~150 lux] /dim [5 lux]), rats underwent behavioral testing, and hippocampal neurons within CA1, CA3, and the dentate gyrus (DG) were examined. Three behavioral effects of dLAN were observed: (1) decreased preference for a sucrose solution, (2) increased latency to float in a forced swim test, and (3) impaired learning and memory in the Barnes maze. Light at night also reduced dendritic length in DG and basilar CA1 dendrites. Dendritic length in the DG positively correlated with sucrose consumption in the sucrose anhedonia task. Nighttime light exposure did not disrupt the pattern of circadian locomotor activity, and all grass rats maintained a diurnal activity pattern. Together, these data suggest that exposure to dLAN can alter affective responses and impair cognition in a diurnal animal.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies of light at night exposure in diurnal rodent species generally yield similar affective responses to nocturnal rodents.
“Studies of light at night exposure in diurnal rodent species generally yield similar affective responses to nocturnal rodents57,58.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [58]
Diurnal rats exposed to dim light at night (5 lux) for 3 weeks demonstrated increased depressive-like behavior and reduced dendritic length within CA1 and dentate gyrus.
“Additionally, diurnal rats exposed to dim light at night (5 lux) for 3 weeks demonstrated increased depressive-like behavior and reduced dendritic length within CA1 and dentate gyrus58.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [58]
Exposure to dim light at night induces depressive-like behavior in multiple species of rodents.
“As with constant light, exposure to dim light at night induces depressive-like behavior in multiple species of rodents58–60,95.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [58]
Neighborhoods that are active at night may directly impact sleep through environmental noise and light.
“There is substantial literature showing that environmental noise228,229 and light230–233 can adversely impact sleep and that neighborhoods that are active at night may directly impact sleep through these.”
From Sleep, Health, and Society (2017) · cites this paper as [230]
Environmental light can adversely impact sleep.
“There is substantial literature showing that environmental noise228,229 and light230–233 can adversely impact sleep and that neighborhoods that are active at night may directly impact sleep through these.”
From Sleep, Health, and Society (2017) · cites this paper as [230]
Cites
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works
McEwen, B. S., & Sapolsky, R. M. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80028-x · Cited by 1,889 · see citing works
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653 · see citing works
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142 · see citing works
Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864 · see citing works
Light at night increases body mass by shifting the time of food intake
Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796 · see citing works
Self-citationBodnoff, S., Humphreys, A., Lehman, J., Diamond, D. M., Rose, G., & Meaney, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00061.1995 · Cited by 522 · see citing works
Neurogenesis in Adult Mammals: Some Progress and Problems
Gould, E., & Gross, C. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00619.2002 · Cited by 510 · see citing works
Davis, S., & Mirick, D. K. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9010-9 · Cited by 302 · see citing works
Shiftwork and Metabolic Risk Factors of Cardiovascular Disease
Ha, M., & Park, J. (2005) · Journal of Occupational Health · doi:10.1539/joh.47.89 · Cited by 276 · see citing works
Bunney, W. E. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00145-1 · Cited by 268 · see citing works
Reiter, R. J., Tan, D., Korkmaz, A., & Ma, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.586365 · Cited by 242 · see citing works
Hippocampal-dependent learning requires a functional circadian system
Ruby, N. F., Hwang, C. E., Wessells, C., Fernandez, F., Zhang, P., Sapolsky, R., & Heller, H. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808259105 · Cited by 234 · see citing works
Magariños, A. M., Li, C. J., Gal Toth, J., Bath, K. G., Jing, D., Lee, F. S., & McEwen, B. S. (2011) · Hippocampus · doi:10.1002/hipo.20744 · Cited by 232 · see citing works
Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
Hajszán, T., Dow, A. L., Warner‐Schmidt, J. L., Szigeti‐Buck, K., Sallam, N. L., Párducz, Á., Leranth, C., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.031 · Cited by 212 · see citing works
Influence of light at night on murine anxiety- and depressive-like responses
Fonken, L. K., Finy, M. S., Walton, J. C., Weil, Z. M., Workman, J. L., Ross, J., & Nelson, R. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.001 · Cited by 209 · see citing works
Self-citationBarnes maze, a useful task to assess spatial reference memory in the mice
Sunyer, B., Patil, S. S., Höger, H., & Luber, G. (2007) · Protocol Exchange · doi:10.1038/nprot.2007.390 · Cited by 201 · see citing works
Gibson, E. M., Wang, C., Tjho, S., Khattar, N., & Kriegsfeld, L. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015267 · Cited by 196 · see citing works
Bedrosian, T. A., Fonken, L. K., Walton, J. C., Haim, A., & Nelson, R. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.01.004 · Cited by 167 · see citing works
Self-citationCircadian rhythms and treatment implications in depression
Monteleone, P., Martiadis, V., & Maj, M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.028 · Cited by 165 · see citing works
A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder
Benedetti, F., Dallaspezia, S., Colombo, C., Pirovano, A., Marino, E., & Smeraldi, E. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.002 · Cited by 149 · see citing works
Ma, W., Cao, J., Tian, M., Cui, M., Han, H., Yang, Y., & Xu, L. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.06.1474 · Cited by 125 · see citing works
From circadian rhythms to clock genes in depression
Turek, F. W. (2007) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000277956.93777.6a · Cited by 114 · see citing works
McElhinny, T. L., Smale, L., & Holekamp, K. E. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00146-7 · Cited by 110 · see citing works
Self-citationThe measurable parameters of the cerebral cortex and their significance in its organization.
SHOLL, D. A. (1956) · PubMed · Cited by 107 · see citing works
Effects of a constant light environment on hippocampal neurogenesis and memory in mice
Fujioka, A., Fujioka, T., Tsuruta, R., Izumi, T., Kasaoka, S., & Maekawa, T. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.001 · Cited by 97 · see citing works
Ashkenazy-Frolinger, T., Kronfeld‐Schor, N., Juetten, J., & Einat, H. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.11.013 · Cited by 70 · see citing works
Willner, P., Muscat, R., & Papp, M. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00286 · Cited by 70 · see citing works
Ling, Z.-Q., Tian, Q., Wang, L., Fu, Z., Wang, X., Wang, Q., & Wang, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0949 · Cited by 60 · see citing works
Effects of continuous exposure to light on behavioral dopaminergic supersensitivity
Abílio, V. C., Freitas, F. M., Dolnikoff, M. S., Castrucci, A. M. D. L., & Frussa‐Filho, R. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00305-9 · Cited by 55 · see citing works
van der Meer, E., Loo, P. L. P. V., & Baumans, V. (2004) · Laboratory Animals · doi:10.1258/0023677041958972 · Cited by 55 · see citing works
Dim Light at Night Increases Immune Function in Nile Grass Rats, a Diurnal Rodent
Fonken, L. K., Haim, A., & Nelson, R. J. (2012) · Chronobiology International · doi:10.3109/07420528.2011.635831 · Cited by 48 · see citing works
Self-citationEffects of long-term continuous exposure to light on memory and anxiety in mice
Castro, J. P. M. V., Frussa-Filho, R., Fukushiro, D. F., Chinen, C. C., Abílio, V. C., & Silva, R. H. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.07.009 · Cited by 41 · see citing works
Targeted mutation of the calbindin D28K gene disrupts circadian rhythmicity and entrainment
Kriegsfeld, L. J., Mei, D. F., Yan, L., Witkovsky, P., LeSauter, J., Hamada, T., & Silver, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06239.x · Cited by 39 · see citing works
Martynhak, B. J., Correia, D., Morais, L. H., Araujo, P., Andersen, M. L., Lima, M. M. S., Louzada, F. M., & Andreatini, R. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.022 · Cited by 26 · see citing works
Cambras, T., Castejón, L., & Dı́ez-Noguera, A. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.010 · Cited by 23 · see citing works
Stress and Depression: Insights from Animal Models
Willner, P. (1997) · Stress Medicine · doi:10.1002/(sici)1099-1700(199710)13:4 · Cited by 9 · see citing works
Duplantier, J., & Bâ, K. (2001) · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
Self-citationLight as a central modulator of circadian rhythms, sleep and affect
LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001 · see citing works
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738 · see citing works
Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720 · see citing works
The Effects of Light at Night on Circadian Clocks and Metabolism
Fonken, L. K., & Nelson, R. J. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1051 · Cited by 468 · see citing works
Self-citationFactors influencing behavior in the forced swim test
Bogdanova, O. V., Kanekar, S., D’Anci, K. E., & Renshaw, P. F. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.05.012 · Cited by 465 · see citing works
A meta-analysis of biological impacts of artificial light at night
Sanders, D., Frago, E., Kehoe, R., Patterson, C., & Gaston, K. J. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-01322-x · Cited by 461 · see citing works
Lunn, R. M., Blask, D. E., Coogan, A. N., Figueiro, M. G., Gorman, M. R., Hall, J. E., Hansen, J., Nelson, R. J., Panda, S., Smolensky, M. H., et al. (2017) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.056 · Cited by 402 · see citing works
Self-citationTiming of light exposure affects mood and brain circuits
Bedrosian, T. A., & Nelson, R. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.262 · Cited by 356 · see citing works
Self-citationDim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight
Fonken, L. K., Aubrecht, T. G., Meléndez‐Fernández, O. H., Weil, Z. M., & Nelson, R. J. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413493862 · Cited by 325 · see citing works
Self-citationHealth Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291 · see citing works
Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal
Fisk, A. S., Tam, S. K. E., Brown, L. A., Vyazovskiy, V. V., Bannerman, D. M., & Peirson, S. N. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00056 · Cited by 278 · see citing works
Kronfeld-Schor, N., Dominoni, D., de la Iglesia, H., Levy, O., Herzog, E. D., Dayan, T., & Helfrich-Forster, C. (2013) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2012.3088 · Cited by 245 · see citing works
Circadian regulation of depression: A role for serotonin
Daut, R., & Fonken, L. (2019) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2019.04.003 · Cited by 196 · see citing works
Self-citationArtificial light at night desynchronizes strictly seasonal reproduction in a wild mammal
Robert, K. A., Lesku, J. A., Partecke, J., & Chambers, B. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.1745 · Cited by 184 · see citing works
Mood, the Circadian System, and Melanopsin Retinal Ganglion Cells
Ospri, L. L., Prusky, G. T., & Hattar, S. S. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031324 · Cited by 179 · see citing works
Grandner, M. A. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.03.001 · Cited by 179 · see citing works
Influence of the modern light environment on mood
Bedrosian, T. A., & Nelson, R. J. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.70 · Cited by 172 · see citing works
Self-citationEndocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170 · see citing works
Self-citationLight at night as an environmental endocrine disruptor
Russart, K. L. G., & Nelson, R. J. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.08.029 · Cited by 169 · see citing works
Self-citationA time to remember: The role of circadian clocks in learning and memory.
Smarr, B. L., Jennings, K. J., Driscoll, J. R., & Kriegsfeld, L. J. (2014) · Behavioral Neuroscience · doi:10.1037/a0035963 · Cited by 166 · see citing works
Urban-associated diseases: Candidate diseases, environmental risk factors, and a path forward
Flies, E. J., Mavoa, S., Zosky, G. R., Mantzioris, E., Williams, C. R., Eri, R. D., Brook, B. W., & Buettel, J. C. (2019) · Environment International · doi:10.1016/j.envint.2019.105187 · Cited by 154 · see citing works
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 145 · see citing works
Grandner, M. A. (2020) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2020.02.017 · Cited by 139 · see citing works
Walker, W. H., Borniger, J. C., Gaudier-Diaz, M. M., Hecmarie Meléndez-Fernández, O., Pascoe, J. L., Courtney DeVries, A., & Nelson, R. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0430-4 · Cited by 129 · see citing works
Self-citationFonken, L. K., Lieberman, R. A., Weil, Z. M., & Nelson, R. J. (2013) · Endocrinology · doi:10.1210/en.2013-1121 · Cited by 125 · see citing works
Self-citationExposure to light at night and risk of depression in the elderly.
Obayashi, K., Saeki, K., Iwamoto, J., Ikada, Y., & Kurumatani, N. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.018 · Cited by 117 · see citing works
Min, J.-Y., & Min, K.-B. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.039 · Cited by 115 · see citing works
Artificial light at night alters trophic interactions of intertidal invertebrates
Underwood, C. N., Davies, T. W., & Queirós, A. M. (2017) · Journal of Animal Ecology · doi:10.1111/1365-2656.12670 · Cited by 112 · see citing works
Obayashi, K., Saeki, K., & Kurumatani, N. (2014) · Chronobiology International · doi:10.3109/07420528.2014.937491 · Cited by 110 · see citing works
Exposure to dim artificial light at night increases REM sleep and awakenings in humans
Cho, C., Lee, H., Yoon, H., Kang, S., Bok, K.-N., Jung, K., Kim, L., & Lee, E. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1108980 · Cited by 104 · see citing works
Red light at intensities above 10 lx alters sleep–wake behavior in mice
Zhang, Z., Wang, H., Wang, D.-R., Qu, W., & Huang, Z. (2016) · Light Science & Applications · doi:10.1038/lsa.2016.231 · Cited by 101 · see citing works
Nocturnal Light Exposure Impairs Affective Responses in a Wavelength-Dependent Manner
Bedrosian, T. A., Vaughn, C. A., Galan, A., Daye, G., Weil, Z. M., & Nelson, R. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5734-12.2013 · Cited by 99 · see citing works
Self-citationDark Matters: The Effects of Artificial Lighting on Bats
Rowse, E. G., Lewanzik, D., Stone, E., Harris, S., & Jones, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-25220-9_7 · Cited by 99 · see citing works
Dim light at night increases depressive-like responses in male C3H/HeNHsd mice
Fonken, L. K., & Nelson, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.12.046 · Cited by 95 · see citing works
Self-citationRumanova, V. S., Okuliarová, M., & Zeman, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155478 · Cited by 93 · see citing works
Artificial light at night and risk of mental disorders: A systematic review
Tancredi, S., Urbano, T., Vinceti, M., & Filippini, T. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155185 · Cited by 93 · see citing works
Leach, G., Adidharma, W., & Yan, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057115 · Cited by 85 · see citing works
Borniger, J. C., Maurya, S. K., Periasamy, M., & Nelson, R. J. (2014) · Chronobiology International · doi:10.3109/07420528.2014.926911 · Cited by 84 · see citing works
Self-citationSinging in the moonlight: dawn song performance of a diurnal bird varies with lunar phase
York, J. E., Young, A. J., & Radford, A. N. (2014) · Biology Letters · doi:10.1098/rsbl.2013.0970 · Cited by 83 · see citing works
Artificial light at night alters behavior in laboratory and wild animals
Russart, K. L. G., & Nelson, R. J. (2018) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2173 · Cited by 81 · see citing works
Self-citationThe role of the circadian clock in animal models of mood disorders.
Landgraf, D., McCarthy, M. J., & Welsh, D. K. (2014) · Behavioral Neuroscience · doi:10.1037/a0036029 · Cited by 77 · see citing works
Circadian regulation in the retina: From molecules to network
Ko, G. Y. ‐. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14185 · Cited by 73 · see citing works
Using light to tell the time of day: sensory coding in the mammalian circadian visual network
Brown, T. M. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.132167 · Cited by 70 · see citing works
Obayashi, K., Saeki, K., & Kurumatani, N. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx290 · Cited by 69 · see citing works
Horsey, E., Maletta, T. A., Turner, H., Cole, C., Lehmann, H., & Fournier, N. M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00272 · Cited by 66 · see citing works
Molčan, Ľ., Šutovská, H. M., Okuliarová, M., Senko, T., Kršková, L., & Zeman, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116568 · Cited by 67 · see citing works
A Comprehensive Overview of the Neural Mechanisms of Light Therapy
Huang, X., Tao, Q., & Ren, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01089-8 · Cited by 71 · see citing works
Effects of light at night on laboratory animals and research outcomes.
Emmer, K. M., Russart, K. L. G., Walker, W. H., Nelson, R. J., & DeVries, A. C. (2018) · Behavioral Neuroscience · doi:10.1037/bne0000252 · Cited by 69 · see citing works
Self-citationCircadian Disruption and Consequences on Innate Immunity and Inflammatory Response
Jerigová, V. Š., Zeman, M., & Okuliarová, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213722 · Cited by 65 · see citing works
Artificial Light at Night Affects Emergence from a Refuge and Space Use in Guppies
Kurvers, R. H. J. M., Drägestein, J., Hölker, F., Jechow, A., Krause, J., & Bierbach, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-32466-3 · Cited by 65 · see citing works
Circadian insights into the biology of depression: Symptoms, treatments and animal models
Mendoza, J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112186 · Cited by 64 · see citing works
Taufique, S. K. T., Prabhat, A., & Kumar, V. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14157 · Cited by 62 · see citing works
Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury
Gaudet, A. D., Ayala, M. T., Schleicher, W. E., Smith, E. J., Bateman, E. M., Maier, S. F., & Watkins, L. R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.05.011 · Cited by 58 · see citing works
Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice
Hogan, M., Kovalycsik, T., Sun, Q., Rajagopalan, S., & Nelson, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.033 · Cited by 54 · see citing works
Self-citationBright nights and social interactions: a neglected issue
Kurvers, R. H. J. M., & Hölker, F. (2014) · Behavioral Ecology · doi:10.1093/beheco/aru223 · Cited by 53 · see citing works
Soler, J. E., Robison, A. J., Núñez, A. A., & Yan, L. (2017) · Hippocampus · doi:10.1002/hipo.22822 · Cited by 69 · see citing works
Misaligned feeding impairs memories
Loh, D. H., Jami, S. A., Flores, R. E., Truong, D. A., Ghiani, C. A., O’Dell, T. J., & Colwell, C. S. (2015) · eLife · doi:10.7554/elife.09460 · Cited by 52 · see citing works
Liu, Q., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2022) · Antioxidants · doi:10.3390/antiox11071218 · Cited by 51 · see citing works
Schroeder, A., Notaras, M., Du, X., & Hill, R. A. (2018) · Brain Sciences · doi:10.3390/brainsci8070121 · Cited by 50 · see citing works
Guerrero‐Vargas, N. N., Navarro-Espíndola, R., Guzmán‐Ruiz, M. A., Basualdo, M. D. C., Espítia‐Bautista, E., López-Bago, A., Lascuraín, R., Córdoba-Manilla, C., Buijs, R. M., & Escobar, C. (2017) · BMC Cancer · doi:10.1186/s12885-017-3636-3 · Cited by 49 · see citing works
González, M. M. C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00609 · Cited by 48 · see citing works
Grunst, M. L., Raap, T., Grunst, A. S., Pinxten, R., Parenteau, C., Angelier, F., & Eens, M. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113895 · Cited by 48 · see citing works
Diurnal rodents as pertinent animal models of human retinal physiology and pathology
Verra, D. M., Sajdak, B. S., Merriman, D. K., & Hicks, D. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100776 · Cited by 45 · see citing works
Dim Light at Night Induced Neurodegeneration and Ameliorative Effect of Curcumin
Namgyal, D., Chandan, K., Sultan, A., Aftab, M., Ali, S., Mehta, R., El‐Serehy, H. A., Al-Misned, F. A., & Sarwat, M. (2020) · Cells · doi:10.3390/cells9092093 · Cited by 42 · see citing works
Spinal Cord Injury in Rats Disrupts the Circadian System
Gaudet, A. D., Fonken, L. K., Ayala, M. T., Bateman, E. M., Schleicher, W. E., Smith, E. J., D’Angelo, H. M., Maier, S. F., & Watkins, L. R. (2018) · eNeuro · doi:10.1523/eneuro.0328-18.2018 · Cited by 40 · see citing works
Self-citationBatra, T., Malik, I., Prabhat, A., Bhardwaj, S. K., & Kumar, V. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2952 · Cited by 39 · see citing works
Disrupted circadian rhythms and mental health
Walker, W. H., Walton, J. C., & Nelson, R. J. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00016-9 · Cited by 45 · see citing works
Self-citationHartsock, M. J., & Spencer, R. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.023 · Cited by 42 · see citing works
Obayashi, K., Saeki, K., & Kurumatani, N. (2014) · Chronobiology International · doi:10.3109/07420528.2014.974809 · Cited by 40 · see citing works
Taufique, S. K. T., & Kumar, V. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.046 · Cited by 38 · see citing works
Ikeno, T., & Yan, L. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416642065 · Cited by 37 · see citing works
Maintaining sleep and physical activity alleviate mood instability
Bowen, R., Balbuena, L., Baetz, M., & Schwartz, L. E. (2013) · Preventive Medicine · doi:10.1016/j.ypmed.2013.06.025 · Cited by 37 · see citing works
Relationship between Human Pupillary Light Reflex and Circadian System Status
Bonmatí‐Carrión, M., Hild, K., Isherwood, C., Sweeney, S. J., Revell, V. L., Skene, D. J., Rol, M. A., & Madrid, J. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162476 · Cited by 39 · see citing works
Disturbances of Hormonal Circadian Rhythms by Light Pollution
Zeman, M., Okuliarová, M., & Rumanova, V. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087255 · Cited by 35 · see citing works
Bilu, C., Einat, H., Zimmet, P., Vishnevskia‐Dai, V., & Kronfeld‐Schor, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-76636-8 · Cited by 37 · see citing works
Chen, R., Routh, B. N., Straetker, J. E., Gibson, C. R., Weitzner, A. S., Bell, K. S., Gaudet, A. D., & Fonken, L. K. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.029 · Cited by 34 · see citing works
Self-citationLeach, G., Ramanathan, C., Langel, J.-L., & Yan, L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.002 · Cited by 34 · see citing works
Chen, R., Weitzner, A. S., McKennon, L. A., & Fonken, L. K. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113171 · Cited by 33 · see citing works
Self-citationSabbah, S., Worden, M. S., Laniado, D. D., Berson, D. M., & Sanes, J. N. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118192119 · Cited by 32 · see citing works
Wang, H. B., Tahara, Y., Luk, S. H. C., Kim, Y.-S., Hitchcock, O. N., Kaswan, Z. A. M., Kim, Y. I., Block, G. D., Ghiani, C. A., Loh, D. H., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105064 · Cited by 32 · see citing works
Hou, Y., Wang, Y., Song, S., Zuo, Y., Zhang, H., Bai, C., Zhao, H., & Zhang, T. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113908 · Cited by 29 · see citing works
Factors That Can Influence Animal Research
Baker, D. G., & Lipman, N. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-409527-4.00033-x · Cited by 30 · see citing works
Li, Y., Zhu, X., Ju, S., Yan, J., Dongqing, W., Zhu, Y. P., & Zang, F. (2017) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25667 · Cited by 29 · see citing works
Bonmati-Carrion, M. A., Baño-Otalora, B., Madrid, J. A., & Rol, M. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-08691-7 · Cited by 26 · see citing works
Night shift hormone: How does melatonin affect depression?
Kholghi, G., Eskandari, M., Saadlou, M.-S. S. Q., Zarrindast, M., & Vaseghi, S. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113835 · Cited by 26 · see citing works
Ikeno, T., & Yan, L. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.002 · Cited by 26 · see citing works
Rest-activity rhythm disturbance in liver cirrhosis and association with cognitive impairment
Kim, M., Liotta, E. M., Maas, M. B., Braun, R., Garcia-Canga, B., Ganger, D. R., Ladner, D. P., Reid, K. J., & Zee, P. C. (2020) · SLEEP · doi:10.1093/sleep/zsaa288 · Cited by 25 · see citing works
Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses
Aubrecht, T. G., Weil, Z. M., Magalang, U. J., & Nelson, R. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00100.2013 · Cited by 25 · see citing works
Self-citationTaufique, S. K. T., Prabhat, A., & Kumar, V. (2018) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2238 · Cited by 24 · see citing works
Martynhak, B. J., Hogben, A. L., Zanos, P., Georgiou, P., Andreatini, R., Kitchen, I., Archer, S. N., von Schantz, M., Bailey, A., & van der Veen, D. R. (2017) · Scientific Reports · doi:10.1038/srep40399 · Cited by 23 · see citing works
Nighttime Light Hurts Mammalian Physiology: What Diurnal Rodent Models Are Telling Us
Mendoza, J. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3020014 · Cited by 23 · see citing works
Low-dose spironolactone in the treatment of female hirsutism.
Ylöstalo, P., Heikkinen, J., Kauppila, A., Pakarinen, A., & Järvinen, P. A. (1987) · PubMed · Cited by 23 · see citing works
Light and Life at Night as Circadian Rhythm Disruptors
Lee, E., & Kim, M. (2019) · Chronobiology in Medicine · doi:10.33069/cim.2019.0016 · Cited by 21 · see citing works
McCarty, R. C., Josephs, T., Kovtun, O., & Rosenthal, S. J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01494-5 · Cited by 18 · see citing works
Molčan, Ľ., Babarikova, K., Cvikova, D., Kincelova, N., Kubincova, L., & Šutovská, H. M. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02901-0 · Cited by 20 · see citing works
Li, M., Cui, J., Xu, B., Wei, Y., Fu, C., Lv, X., Xiong, L., & Qin, D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.827541 · Cited by 19 · see citing works
Datta, S., Samanta, D., Sinha, P., & Chakrabarti, N. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.049 · Cited by 19 · see citing works
Kumar, A., Prabhat, A., Kumar, V., & Bhardwaj, S. K. (2023) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00447-9 · Cited by 18 · see citing works
Sangma, J. T., & Trivedi, A. K. (2023) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00451-z · Cited by 18 · see citing works
- Authors
- Fonken, L. K., Kitsmiller, E., Smale, L., & Nelson, R. J.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Michigan State University (US)
- Corresponding author
- Fonken, Laura K.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2012-08
- Volume
- 27
- Issue
- 4
- Pages
- 319-327
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2160296060
- Cited by
- 203
- References
- 40
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 16 · 2023: 11 · 2022: 20 · 2021: 14 · 2020: 15 · 2019: 11 · 2018: 16 · 2017: 19 · 2016: 11 · 2015: 11 · 2014: 13 · 2013: 16
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- American Heart Association
- United States - Israel Binational Science Foundation
- United States-Israel Binational Science Foundation
- Israel Science Foundation
- Division of Integrative Organismal Systems
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- dim light at night, circadian rhythm disruption, diurnal rodents, Nile grass rat, cognitive impairment, depression-like behavior, hippocampus, learning and memory, forced swim test, circadian locomotor activity, artificial light at night
- MeSH terms
- Analysis of Variance, Animals, Circadian Rhythm, Cognition, Corticosterone, Dendrites, Depressive Disorder, Food Preferences, Light, Male, Motor Activity, Neurons, Swimming, Photoperiod, Maze Learning, Dentate Gyrus, Murinae, CA1 Region, Hippocampal, CA3 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
