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Cited by 286Transcranial Magnetic Stimulation StudiesElectroconvulsive Therapy StudiesNeurological disorders and treatments

Transcranial direct current stimulation: A roadmap for research, from mechanism of action to clinical implementation

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Chase, Henry W., Boudewyn, Megan A., Carter, Cameron S., Phillips, Mary L.·2020·Molecular Psychiatry
DOI 10.1038/s41380-019-0499-9PMC PMC6981019
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Abstract

Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the method might have such an effect, and uncertainties surrounding its influence on neural activity, and human cognition and functioning. In the present critical review, we identify key priorities for future research into major depression and schizophrenia, including studies of the mechanism(s) of action of tDCS at the neuronal and systems levels, the establishment of the cognitive impact of tDCS, as well as investigations of the potential clinical efficacy of tDCS. We highlight areas of progress in each of these domains, including data that appear to favor an effect of tDCS on neural oscillations rather than spiking, and findings that tDCS administration to the prefrontal cortex during task training may be an effective way to enhance behavioral performance. Finally, we provide suggestions for further empirical study that will elucidate the impact of tDCS on brain and behavior, and may pave the way for efficacious clinical treatments for psychiatric disorders.

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  • Skepticism is increased by lack of clear theories and evidence on working mechanisms of both interventions, which hampers smart applications.

    “Skepticism is increased by lack of clear theories and evidence on working mechanisms of both interventions, which hampers smart applications (Chase, Boudewyn, Carter, & Phillips, 2020; Singh, Erwin-Grabner, Goya-Maldonado, & Antal, 2019)”

    From Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis (2020) · cites this paper as Chase, Boudewyn, Carter, & Phillips, 2020

    The “Mechanism(s) of action” section says that limited understanding of how tDCS affects brain circuitry constrains experimental design, and that better mechanistic understanding would help calibrate protocols. This supports the claim for tDCS, but the passage does not address both interventions or say that this uncertainty increases skepticism. Page numbers were not supplied with the passages. (LLM, conf=0.83)

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Authors
Chase, H. W., Boudewyn, M. A., Carter, C. S., & Phillips, M. L.
Affiliations
  • University of Pittsburgh (US)
  • University of California, Davis (US)
Corresponding author
Chase, Henry W.
ORCID
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2019-08-27
Volume
25
Issue
2
Pages
397-407
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/s41380-019-0499-9
PMC
PMC6981019
OpenAlex
W2970012072
Cited by
286
References
12
Citations by year
2026: 41 · 2025: 54 · 2024: 57 · 2023: 54 · 2022: 46 · 2021: 19 · 2020: 13 · 2019: 1
FWCI
2.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (1R21MH108421-01A1)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
transcranial direct current stimulation, mechanism of action, major depressive disorder, schizophrenia, neural oscillations, prefrontal cortex, task training, cognitive enhancement, clinical efficacy, neuromodulation, mental illness
MeSH terms
Mental Disorders, Brain, Cognition, Major Depressive Disorder, Humans, Neurons, Schizophrenia, Prefrontal Cortex, Transcranial Direct Current Stimulation

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