The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?
Abstract
Chemoresistance remains a major complication of cancer treatments. Recent data provide strong evidence that chemoresistance is linked to epithelial-mesenchymal transition (EMT), a latent developmental process, which is re-activated during cancer progression. EMT involves transcriptional reprogramming and is driven by specific EMT transcription factors (EMT-TFs). In this review, we provide support for the idea that EMT-TFs contribute to the development of resistance against cancer therapy and discuss how EMT-TFs might be targeted to advance novel therapeutic approaches to the treatment of cancer.
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“EMT also correlates with increased resistance of carcinoma cells to chemotherapies149–152.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [150]
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Wu, Y., Tran, T., Dwabe, S., Sarkissyan, M., Kim, J., Nava, M., Clayton, S., Pietras, R. J., Farias‐Eisner, R., & Vadgama, J. V. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4211-y · Cited by 53
RetractedSlug contributes to cancer progression by direct regulation of ERα signaling pathway
Li, Y., Wu, Y., ABBATIELLO, T. C., Wu, W., Kim, J. R., Sarkissyan, M., Sarkissyan, S., CHUNG, S. S., Elshimali, Y., & Vadgama, J. V. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2878 · Cited by 44
RetractedMacrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400
Cancer drug resistance: an evolving paradigm
Holohan, C., Van Schaeybroeck, S., Longley, D. B., & Johnston, P. G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3599 · Cited by 4,681
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852
Cano, A., Pérez‐Moreno, M., Rodrigo, I., Locascio, A., Blanco, M. J., Barrio, M. G. D., Portillo, F., & Nieto, M. A. (2000) · Nature Cell Biology · doi:10.1038/35000025 · Cited by 3,672
Emerging Biological Principles of Metastasis
Lambert, A. W., Pattabiraman, D. R., & Weinberg, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.037 · Cited by 3,191
Research works printed but not linked: 1
- Ban YG, Yang JJ, Chang Y, Wang YL, Liu Y. USP7 promotes tumorigenesis in breast cancer and enhances MRI detection. Int J Clin Exp Med. 2016;9:10018–27.
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TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944
Endocytosis in the context-dependent regulation of individual and collective cell properties
Sigismund, S., Lanzetti, L., Scita, G., & Di Fiore, P. P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00375-5 · Cited by 132
Metadata
- Authors
- van Staalduinen, J., Baker, D., ten Dijke, P., & van Dam, H.
- Affiliations
- Leiden University Medical Center (NL)
- ORCID
- Baker, David
- Venue
- Oncogene
- Published
- 2018-07-12
- Volume
- 37
- Issue
- 48
- Pages
- 6195-6211
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2870937227
- Cited by
- 158
- References
- 205
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 13 · 2023: 18 · 2022: 30 · 2021: 27 · 2020: 32 · 2019: 22 · 2018: 1
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Cancer Genomics Centre
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- epithelial-mesenchymal transition, EMT transcription factors, chemoresistance, cancer therapy resistance, transcriptional reprogramming, targeted cancer therapy, tumor progression
- MeSH terms
- Animals, Humans, Neoplasms, Transcription Factors, Drug Resistance, Neoplasm, Epithelial-Mesenchymal Transition
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