Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

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EMT: 2016

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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

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Emerging Biological Principles of Metastasis

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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

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TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

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A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

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The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

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Direct regulation of TWIST by HIF-1α promotes metastasis

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Epithelial–mesenchymal plasticity in carcinoma metastasisPreprint

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The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

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Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

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Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

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ABC transporters in cancer: more than just drug efflux pumps

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Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

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The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

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Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

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Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

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Snail blocks the cell cycle and confers resistance to cell deathPreprint

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Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

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Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

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Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

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A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

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Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex

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Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

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Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

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Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells

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Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

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Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to Paclitaxel

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A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

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ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1

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Chronic Oxaliplatin Resistance Induces Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cell Lines

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Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expressionPreprint

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Tumor Budding: The Name is EMT. Partial EMT.

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Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

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MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination

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G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

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TGF-β–induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops

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Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2

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MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

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Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters

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miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy

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EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

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Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

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Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

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ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading

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The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1

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E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

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Evidence for a function of CtBP in epithelial gene regulation and anoikis

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Aberrant Expression of the Transcription Factors Snail and Slug Alters the Response to Genotoxic Stress

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Tumor promoting role of anti-tumor macrophages in tumor microenvironment

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Hypoxia‐inducing factors as master regulators of stemness properties and altered metabolism of cancer‐ and metastasis‐initiating cells

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Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

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Metabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer

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Upholding a role for EMT in breast cancer metastasis

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An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

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Regulation of lncRNA and Its Role in Cancer Metastasis

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Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

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Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma

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Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition

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TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis

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SET8 promotes epithelial–mesenchymal transition and confers TWIST dual transcriptional activities

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Upholding a role for EMT in pancreatic cancer metastasis

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Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

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Levels of Gemcitabine Transport and Metabolism Proteins Predict Survival Times of Patients Treated With Gemcitabine for Pancreatic Adenocarcinoma

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ZEB1‐associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

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Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

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Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

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Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells

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LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma

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Targeting TGF-β signaling in cancer

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Invading one step at a time: the role of invadopodia in tumor metastasis

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Hypoxia-inducible factors: a central link between inflammation and cancer

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TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation

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Epithelial–Mesenchymal Transition and Tumor Suppression Are Controlled by a Reciprocal Feedback Loop between ZEB1 and Grainyhead-like-2

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miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13

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MiR‐200c suppresses TGF‐β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer

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Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

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EGFRMutation Conferring Primary Resistance to Gefitinib in Non–Small-Cell Lung Cancer

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Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

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PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung

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Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α

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The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity

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Crosstalk of Oncogenic Signaling Pathways during Epithelial–Mesenchymal Transition

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Slug Confers Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

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Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

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Regulation of Excision Repair Cross-Complementation Group 1 by Snail Contributes to Cisplatin Resistance in Head and Neck Cancer

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miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin

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Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy

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PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma

Ock, C.-Y., Kim, S., Keam, B., Kim, M., Kim, T. M., Kim, J.-H., Jeon, Y. K., Lee, J., Kwon, S. K., Hah, J. H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7431 · Cited by 150

Epigenetic regulation of epithelial–mesenchymal transition

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Long Non-coding RNAs (LncRNA) Regulated by Transforming Growth Factor (TGF) β

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New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

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Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT)

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Acquisition of epithelial–mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway

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The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

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ZEB1‐mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

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The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma

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Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial–Mesenchymal Transition in Cancer

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Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

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Epithelial to Mesenchymal Transition Is Activated in Metastatic Pheochromocytomas and Paragangliomas Caused by SDHB Gene Mutations

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PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage

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OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

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F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check

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The role of epithelial–mesenchymal transition drivers ZEB 1 and ZEB 2 in mediating docetaxel‐resistant prostate cancer

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Expression of Snail in Pancreatic Cancer Promotes Metastasis and Chemoresistance

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Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a

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Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)

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Chemoresistance to 5-fluorouracil induces epithelial–mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells

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OVOL guides the epithelial-hybrid-mesenchymal transition

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Inhibition of ZEB1 reverses EMT and chemoresistance in docetaxel‐resistant human lung adenocarcinoma cell line

Ren, J., Chen, Y., Song, H., Chen, L., & Wang, R. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24481 · Cited by 119

MicroRNA Regulation of Epithelial to Mesenchymal Transition

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Epithelial–mesenchymal plasticity and circulating tumor cells: Travel companions to metastases

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Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice

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Extracellular vesicles: their role in cancer biology and epithelial–mesenchymal transition

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The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation

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Synergistic Enhancement of CD8+ T Cell–Mediated Tumor Vaccine Efficacy by an Anti–Transforming Growth Factor-β Monoclonal Antibody

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Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway

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miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K/Akt signaling pathway and inhibites cell migration via targeting ZEB1

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Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication

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Pivotal Roles of Snail Inhibition and RKIP Induction by the Proteasome Inhibitor NPI-0052 in Tumor Cell Chemoimmunosensitization

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Reduced Expression of miR-200 Family Members Contributes to Antiestrogen Resistance in LY2 Human Breast Cancer Cells

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Induction of Stem Cell Factor/c-Kit/Slug Signal Transduction in Multidrug-resistant Malignant Mesothelioma Cells

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Immunological Consequences of Epithelial–Mesenchymal Transition in Tumor Progression

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Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer

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Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner

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SNAI1-Mediated Epithelial-Mesenchymal Transition Confers Chemoresistance and Cellular Plasticity by Regulating Genes Involved in Cell Death and Stem Cell Maintenance

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ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

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miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling

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δ EF1 associates with DNMT1 and maintains DNA methylation of the E‐cadherin promoter in breast cancer cells

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Context-specific roles of EMT programmes in cancer cell dissemination

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Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy

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Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors

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Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models

Roberts, C. M., Shahin, S. A., Wen, W. X., Finlay, J. B., Dong, J. I., Wang, R., Dellinger, T. H., Zink, J. I., Tamanoi, F., & Glackin, C. A. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.11.010 · Cited by 85

miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells

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Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment

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FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells

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Epithelial‐to‐mesenchymal transition transcription factors in cancer‐associated fibroblasts

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Epithelial-mesenchymal Transition is Associated with Acquired Resistance to 5-Fluorocuracil in HT-29 Colon Cancer Cells

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Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway

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Snail-induced epithelial-mesenchymal transition promotes cancer stem cell-like phenotype in head and neck cancer cells

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A genetic cell context-dependent role for ZEB1 in lung cancer

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USP2a Supports Metastasis by Tuning TGF-β Signaling

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Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic Adenoviruses

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Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination

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Twist mediates an aggressive phenotype in human colorectal cancer cells

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Anti‐apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells

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TGF-β1-Induced Epithelial–Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells

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Regulation of E-Cadherin Gene Expression during Tumor Progression: The Role of a New Ets-Binding Site and the E-pal Element

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miR-125b Functions as a Key Mediator for Snail-induced Stem Cell Propagation and Chemoresistance

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Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells

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