The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence
Abstract
This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal-epithelial transition factor (c-MET)) signaling pathway in cancers. First, we generalize the compelling influence of HGF/c-MET pathway on multiple cellular processes. Then, we present the genomic characterization of HGF/c-MET pathway in carcinogenesis. Furthermore, we extensively illustrate the malignant biological behaviors of HGF/c-MET pathway in cancers, in which hyperactive HGF/c-MET signaling is considered as a hallmark. In addition, we investigate the current clinical trials of HGF/c-MET-targeted therapy in cancers. We find that although HGF/c-MET-targeted therapy has led to breakthroughs in certain cancers, monotherapy of targeting HGF/c-MET has failed to demonstrate significant clinical efficacy in most cancers. With the advantage of the combinations of HGF/c-MET-targeted therapy, the exploration of more options of combinational targeted therapy in cancers may be the major challenge in the future.
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“c-MET signaling is hyperactivated in multiple cancers, due to MET mutations, amplification, or rearrangement [238].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [238]
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Items 201–203 of 203
Kim, H., Youk, J., Yang, Y., Kim, T., Min, A., Ham, H. S., Cho, S., Lee, K.-H., Keam, B., Han, S., et al. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-015-2072-5 · Cited by 8
Interplay between dietary inducers of GST and theGSTM-1 genotype in colon cancer
Slattery, M. L., Kampman, E., Samowitz, W. S., Caan, B. J., & Potter, J. D. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20000901)87:5 · Cited by 2
Vereshchagin, I. A., Kovalenko, T. I., & Lt, K. (1983) · PubMed · Cited by 2
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Sorted by citations
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions
Yi, M., Zheng, X., Niu, M., Zhu, S., Ge, H., & Wu, K. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01489-2 · Cited by 1,445
Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges
Ubanako, P., Mirza, S., Ruff, P., & Penny, C. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1447953 · Cited by 68
Ye, Q., Zhou, X., Ren, H., Han, F., Lin, R., & Li, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1274336 · Cited by 15
Reimagining cancer treatments in the era of generative AI
Derbal, Y. (2025) · DIGITAL HEALTH · doi:10.1177/20552076251394631 · Cited by 4
Metadata
- Authors
- Fu, J., Su, X., Li, Z., Deng, L., Liu, X., Feng, X., & Peng, J.
- Affiliations
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Corresponding author
- Feng, Xuancheng
- Peng, Juan
- Venue
- Oncogene
- Published
- 2021-06-18
- Volume
- 40
- Issue
- 28
- Pages
- 4625-4651
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W3171106033
- Cited by
- 235
- References
- 203
- Citations by year
- 2026: 39 · 2025: 63 · 2024: 54 · 2023: 48 · 2022: 25 · 2021: 5
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Mechanisms and Therapy
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- HGF/c-Met signaling pathway, hepatocyte growth factor, c-Met, carcinogenesis, tumor progression, combination targeted therapy, clinical trials
- MeSH terms
- Animals, Humans, Neoplasms, Signal Transduction, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Molecular Targeted Therapy
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