The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
The intracellular signalosome of PD-L1 in cancer cells
Open accessAbstract
Programmed cell death-1 ligand-1 (PD-L1) overexpression in cancer cells accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First, PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to the inhibitory receptor PD-1. Second, PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival, regulate stress responses and confer resistance toward pro-apoptotic stimuli, such as interferons. Here, we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1, describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies.
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Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
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Cited by
Cotton, A. D., Nguyen, D. P., Gramespacher, J. A., Seiple, I. B., & Wells, J. A. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.0c10008 · Cited by 551
Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation
Zhang, H., Han, Y., Yang, Y., Lin, F., Li, K., Kong, L., Liu, H., Dang, Y., Lin, J., & Chen, P. R. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c08521 · Cited by 292
Hudson, K., Cross, N., Jordan-Mahy, N., & Leyland, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.568931 · Cited by 243
Current and future perspectives of PD-1/PDL-1 blockade in cancer immunotherapy
Makuku, R., Khalili, N., Razi, S., Keshavarz-Fathi, M., & Rezaei, N. (2021) · Journal of Immunology Research · doi:10.1155/2021/6661406 · Cited by 136
Minz, A. P., Mohapatra, D., Dutta, M., Sethi, M., Parida, D., Mohapatra, A. P., Mishra, S., Kar, S., Sasmal, P. K., & Senapati, S. (2023) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-023-03562-9 · Cited by 24
Metadata
- Authors
- Escors, D., Gato-Cañas, M., Zuazo, M., Arasanz, H., García-Granda, M. J., Vera, R., & Kochan, G.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2018-09-28
- Volume
- 3
- Issue
- 1
- Pages
- 26-26
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W2890296921
- Cited by
- 292
- References
- 114
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Escors, D., Gato-Cañas, M., Zuazo, M., Arasanz, H., García-Granda, M. J., Vera, R., & Kochan, G. (2018). The intracellular signalosome of PD-L1 in cancer cells. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-018-0022-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
