The DOI matches its Crossref record; 325 of the 325 references it cites were found in a registry or an index.
Targeting cell signaling in allergic asthma
Open accessAbstract
Asthma is chronic inflammation of the airways characterized by airway hyper-responsiveness, wheezing, cough, and dyspnea. Asthma affects >350 million people worldwide. The Th2 immune response is a major contributor to the pathophysiology of asthma. Targeted therapy modulating cell signaling pathways can be a powerful strategy to design new drugs to treat asthma. The potential molecular pathways that can be targeted include IL-4-IL-13-JAK-STAT-MAP kinases, adiponectin-iNOS-NF-κB, PGD2-CRTH2, IFNs-RIG, Wnt/β-catenin-FAM13A, FOXC1-miR-PI3K/AKT, JNK-Gal-7, Nrf2-ROS, Foxp3-RORγt, CysLTR, AMP, Fas-FasL, PTHrP/PPARγ, PAI-1, FcɛRI-LAT-SLP-76, Tim-3-Gal-9, TLRs-MyD88, PAR2, and Keap1/Nrf2/ARE. Therapeutic drugs can be designed to target one or more of these pathways to treat asthma.
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1 retracted
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Cited by
PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress
Liu, K., Hua, S., & Song, L. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3618806 · Cited by 187
Atopic Dermatitis: The Relationship Between Immune Mediators and Skin Lipid Barrier
You, H., & Liang, Y. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09057-y · Cited by 17
Metadata
- Authors
- Athari, S. S.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2019-10-18
- Volume
- 4
- Issue
- 1
- Pages
- 45-45
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W2980465010
- Cited by
- 312
- References
- 325
- FWCI
- 16.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Athari, S. S. (2019). Targeting cell signaling in allergic asthma. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-019-0079-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
