Toll-like receptors: critical proteins linking innate and acquired immunity

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works

Innate Immunity: The Virtues of a Nonclonal System of Recognition

Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434 · see citing works

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442 · cited 1× · see citing works

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · see citing works

Toll-like receptors and innate immunity

Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308 · see citing works

NF-κB regulation in the immune system

Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works

Tissue-resident macrophages

Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096 · see citing works

Innate immune recognition of viral infection

Kawai, T., & Akira, S. (2006) · Nature Immunology · doi:10.1038/ni1303 · Cited by 1,899 · see citing works

The role of inflammation in epilepsy

Vezzani, A., French, J., Bartfai, T., & Baram, T. Z. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.178 · Cited by 1,876 · see citing works

Negative regulation of Toll-like receptor-mediated immune responses

Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509 · see citing works

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works

NADPH oxidases: An overview from structure to innate immunity-associated pathologies

Panday, A., Sahoo, M. K., Osorio, D., & Batra, S. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2014.89 · Cited by 944 · see citing works

Interaction between the gut microbiome and mucosal immune system

Shi, N., Li, N., Duan, X., & Niu, H. (2017) · Military Medical Research · doi:10.1186/s40779-017-0122-9 · Cited by 940 · see citing works

TREMs in the immune system and beyond

Colonna, M. (2003) · Nature Reviews Immunology · doi:10.1038/nri1106 · Cited by 701 · see citing works

The macrophage foam cell as a target for therapeutic intervention

Li, A. C., & Glass, C. K. (2002) · Nature Medicine · doi:10.1038/nm1102-1235 · Cited by 700 · see citing works

Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials

Sheikh, Z., Brooks, P., Barzilay, O., Fine, N., & Glogauer, M. (2015) · Materials · doi:10.3390/ma8095269 · Cited by 701 · see citing works

Bacterial translocation (BT) in cirrhosis†

Wiest, R., & Garcia‐Tsao, G. (2005) · Hepatology · doi:10.1002/hep.20632 · Cited by 677 · see citing works

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., & Ichijo, H. (2005) · Nature Immunology · doi:10.1038/ni1200 · Cited by 667 · see citing works

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

Park, H. S., Jung, H. Y., Park, E. Y., Kim, J., Lee, W. J., & Bae, Y. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3589 · Cited by 635 · see citing works

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., & Yoshimura, A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00446-6 · Cited by 630 · see citing works

Cutting edge: impaired toll-like receptor expression and function in aging

Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4697 · Cited by 626 · see citing works

Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion

Jensen, S., & Thomsen, A. R. (2012) · Journal of Virology · doi:10.1128/jvi.05738-11 · Cited by 604 · see citing works

Nucleic acid recognition by the innate immune system

Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577 · see citing works

Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4

Taylor, K. R., Trowbridge, J. M., Rudisill, J. A., Termeer, C. C., Simon, J. C., & Gallo, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310859200 · Cited by 545 · see citing works

Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids

Lee, J. Y., Ye, J., Gao, Z., Youn, H. S., Lee, W. H., Zhao, L., Sizemore, N., & Hwang, D. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305213200 · Cited by 524 · see citing works

Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis

Erkes, D. A., Cai, W., Sanchez, I. M., Purwin, T. J., Rogers, C., Field, C. O., Berger, A. C., Hartsough, E. J., Rodeck, U., Alnemri, E. S., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0672 · Cited by 459 · see citing works

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

Butovsky, O., Siddiqui, S., Gabriely, G., Lanser, A. J., Dake, B., Murugaiyan, G., Doykan, C. E., Wu, P. M., Gali, R. R., Iyer, L. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62636 · Cited by 481 · see citing works

Toll-like receptors induce a phagocytic gene program through p38

Doyle, S. E., O'Connell, R. M., Miranda, G. A., Vaidya, S. A., Chow, E. K., Liu, P. T., Suzuki, S., Suzuki, N., Modlin, R. L., Yeh, W.-C., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031237 · Cited by 433 · see citing works

Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut

Melmed, G., Thomas, L. S., Lee, N., Tesfay, S. Y., Lukasek, K., Michelsen, K. S., Zhou, Y., Hu, B., Arditi, M., & Abreu, M. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1406 · Cited by 431 · see citing works

A review on macrophage responses to biomaterials

Xia, Z., & Triffitt, J. T. (2006) · Biomedical Materials · doi:10.1088/1748-6041/1/1/r01 · Cited by 418 · see citing works

Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

Balić, A., Vlašić, D., Žužul, K., Marinović, B., & Bukvić Mokos, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030741 · Cited by 400 · see citing works

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

Shi, C.-S., & Kehrl, J. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804478200 · Cited by 395 · see citing works

The immune response to fungal infections

Shoham, S., & Levitz, S. M. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05397.x · Cited by 392 · see citing works

Neutrophils at the crossroads of innate and adaptive immunity

Rosales, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0220-574rr · Cited by 372 · see citing works

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

Henault, J., Martinez, J., Riggs, J. M., Tian, J., Mehta, P., Clarke, L., Sasai, M., Latz, E., Brinkmann, M. M., Iwasaki, A., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.014 · Cited by 348 · see citing works

The Role of Macrophages in Cancer Development and Therapy

Cendrowicz, E., Sas, Z., Bremer, E., & Rygiel, T. P. (2021) · Cancers · doi:10.3390/cancers13081946 · Cited by 332 · see citing works

DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH

Gäbele, E., Dostert, K., Hofmann, C., Wiest, R., Schölmerich, J., Hellerbrand, C., & Obermeier, F. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.035 · Cited by 324 · see citing works

Toll‐Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility

Sameer, A. S., & Nissar, S. (2021) · BioMed Research International · doi:10.1155/2021/1157023 · Cited by 323 · see citing works

Immune Recognition of Tumor-Associated Mucin MUC1 is Achieved by a Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J., & Boons, G.-J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115166109 · Cited by 301 · see citing works

Microbial recognition by Toll-like receptors

Takeda, K., & Akira, S. (2004) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2003.10.002 · Cited by 285 · see citing works

An Angiogenic Switch in Macrophages Involving Synergy between Toll-Like Receptors 2, 4, 7, and 9 and Adenosine A2A Receptors

Pinhal-Enfield, G., Ramanathan, M., Hasko, G., Vogel, S. N., Salzman, A. L., Boons, G.-J., & Leibovich, S. J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63698-x · Cited by 278 · see citing works

A selective gut bacterial bile salt hydrolase alters host metabolism

Yao, L., Seaton, S. C., Ndousse-Fetter, S., Adhikari, A. A., DiBenedetto, N., Mina, A. I., Banks, A. S., Bry, L., & Devlin, A. S. (2018) · eLife · doi:10.7554/elife.37182 · Cited by 274 · see citing works

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S.-I., & Koshiba, T. (2009) · Science Signaling · doi:10.1126/scisignal.2000287 · Cited by 255 · see citing works

Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72

Johnson, J. D., & Fleshner, M. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905523 · Cited by 251 · see citing works

Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis

Wurfel, M. M., Gordon, A. C., Holden, T. D., Radella, F., Strout, J., Kajikawa, O., Ruzinski, J. T., Rona, G., Black, A. R., Stratton, S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200803-462oc · Cited by 244 · see citing works

Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen

Foley, E., & O'Farrell, P. H. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020203 · Cited by 238 · see citing works

Respiratory Syncytial Virus–Induced Activation of Nuclear Factor–κB in the Lung Involves Alveolar Macrophages and Toll‐Like Receptor 4–Dependent Pathways

Haeberle, H. A., Takizawa, R., Casola, A., Brasier, A. R., Dieterich, H., van Rooijen, N., Gatalica, Z., & Garofalo, R. P. (2002) · The Journal of Infectious Diseases · doi:10.1086/344644 · Cited by 237 · see citing works

IL-12 Receptor β1 and Toll-Like Receptor 4 Increase IL-1β- and IL-18-Associated Myocarditis and Coxsackievirus Replication

Fairweather, D., Yusung, S., Frisancho, S., Barrett, M., Gatewood, S., Steele, R., & Rose, N. R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4731 · Cited by 229 · see citing works

A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease

Fort, M. M., Mozaffarian, A., Stöver, A. G., Correia, J. D. S., Johnson, D. A., Crane, R. T., Ulevitch, R. J., Persing, D. H., Bielefeldt-Ohmann, H., Probst, P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6416 · Cited by 216 · see citing works

Innate and Adaptive Immune Responses in Wound Epithelialization

Strbo, N., Yin, N., & Stojadinovic, O. (2014) · Advances in Wound Care · doi:10.1089/wound.2012.0435 · Cited by 200 · see citing works

ERK Activation Following Macrophage FcγR Ligation Leads to Chromatin Modifications at the IL-10 Locus

Lucas, M., Zhang, X., Prasanna, V., & Mosser, D. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.469 · Cited by 197 · see citing works

Toll-Like Receptor 2 Is Required for Optimal Control of<i>Listeria monocytogenes</i>Infection

Torres, D., Barrier, M., Bihl, F., Quesniaux, V. J. F., Maillet, I., Akira, S., Ryffel, B., & Erard, F. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2131-2139.2004 · Cited by 191 · see citing works

Macrophage and dendritic cell phenotypic diversity in the context of biomaterials

Kou, P. M., & Babensee, J. E. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32971 · Cited by 190 · see citing works

Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles

Vanpouille-Box, C., Hoffmann, J. A., & Galluzzi, L. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0043-2 · Cited by 183 · see citing works

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

Barochia, A., Solomon, S., Cui, X., Natanson, C., & Eichacker, P. Q. (2011) · Expert Opinion on Drug Metabolism &amp; Toxicology · doi:10.1517/17425255.2011.558190 · Cited by 169 · see citing works

Absence of IL-1 Receptor Antagonist Impaired Wound Healing along with Aberrant NF-κB Activation and a Reciprocal Suppression of TGF-β Signal Pathway

Ishida, Y., Kondo, T., Kimura, A., Matsushima, K., & Mukaida, N. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.9.5598 · Cited by 168 · see citing works

NF-κB, an Evolutionarily Conserved Mediator of Immune and Inflammatory Responses

Xiao, C., & Ghosh, S. (2005) · Advances in Experimental Medicine and Biology · doi:10.1007/0-387-24180-9_5 · Cited by 167 · see citing works

The Nuclear IκB Protein IκBNS Selectively Inhibits Lipopolysaccharide-Induced IL-6 Production in Macrophages of the Colonic Lamina Propria

Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., & Takeda, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3650 · Cited by 167 · see citing works

Polyunsaturated fatty acids, neuroinflammation and well being

Layé, S. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.006 · Cited by 167 · see citing works

TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

Standiford, T. J., Kuick, R., Bhan, U., Chen, J., Newstead, M., & Keshamouni, V. G. (2011) · Oncogene · doi:10.1038/onc.2010.619 · Cited by 151 · see citing works

Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner

Murray, E., Sharma, R., Smith, K. B., Mar, K. D., Barve, R., Lukasik, M., Pirwani, A. F., Malette-Guyon, E., Lamba, S., Thomas, B. J., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.016 · Cited by 150 · see citing works

Enhanced Apoptotic Cell Clearance Capacity and B Cell Survival Factor Production by IL-10-Activated Macrophages: Implications for Burkitt’s Lymphoma

Ogden, C. A., Pound, J. D., Batth, B. K., Owens, S., Johannessen, I., Wood, K., & Gregory, C. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.3015 · Cited by 147 · see citing works

The Skin-Resident Immune Network

Tay, S. S., Roediger, B., Tong, P. L., Tikoo, S., & Weninger, W. (2014) · Current Dermatology Reports · doi:10.1007/s13671-013-0063-9 · Cited by 147 · see citing works

Toll-like receptor 4 plays a crucial role in the immune–adrenal response to systemic inflammatory response syndrome

Zacharowski, K., Zacharowski, P. A., Koch, A., Baban, A., Tran, N., Berkels, R., Papewalis, C., Schulze-Osthoff, K., Knuefermann, P., Zähringer, U., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601527103 · Cited by 134 · see citing works

Age-related macular degeneration and the immune response: implications for therapy

Nussenblatt, R. B., & Ferris, F. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.06.025 · Cited by 130 · see citing works

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

van den Biggelaar, A. H. J., Huizinga, T. W. J., de Craen, A. J. M., Gussekloo, J., Heijmans, B. T., Frölich, M., & Westendorp, R. G. J. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.009 · Cited by 122 · see citing works

Phospholipase Cγ-2 and Intracellular Calcium Are Required for Lipopolysaccharide-induced Toll-like Receptor 4 (TLR4) Endocytosis and Interferon Regulatory Factor 3 (IRF3) Activation

Chiang, C.-Y., Veckman, V., Limmer, K., & David, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.328559 · Cited by 120 · see citing works

Microbial exposure enhances immunity to pathogens recognized by TLR2 but increases susceptibility to cytokine storm through TLR4 sensitization

Huggins, M. A., Sjaastad, F. V., Pierson, M., Kucaba, T. A., Swanson, W., Staley, C., Weingarden, A. R., Jensen, I. J., Danahy, D. B., Badovinac, V. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.028 · Cited by 114 · see citing works

Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity

Kanayama, M., Inoue, M., Danzaki, K., Hammer, G., He, Y.-W., & Shinohara, M. L. (2015) · Nature Communications · doi:10.1038/ncomms6779 · Cited by 114 · see citing works

In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid

Yamada, H., Yoshida, M., Nakano, Y., Suganami, T., Satoh, N., Mita, T., Azuma, K., Itoh, M., Yamamoto, Y., Kamei, Y., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.171736 · Cited by 112 · see citing works

Evading innate immunity in nonviral mRNA delivery: don't shoot the messenger.

Devoldere, J., Dewitte, H., De Smedt, S. C., & Remaut, K. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2015.07.009 · Cited by 112 · see citing works

Immunokinetics in severe pneumonia due to influenza virus and bacteria coinfection in mice.

Seki, M., Yanagihara, K., Higashiyama, Y., Fukuda, Y., Kaneko, Y., Ohno, H., Miyazaki, Y., Hirakata, Y., Tomono, K., Kadota, J., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00126103 · Cited by 103 · see citing works

Probiotics: Immunomodulation and Evaluation of Safety and Efficacy

Ezendam, J., & Loveren, H. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00168.x · Cited by 103 · see citing works

Fucoidan isolated from Padina commersonii inhibit LPS-induced inflammation in macrophages blocking TLR/NF-κB signal pathway

Asanka Sanjeewa, K. K., Jayawardena, T. U., Kim, H.-S., Kim, S.-Y., Shanura Fernando, I. P., Wang, L., Abetunga, D. T. U., Kim, W.-S., Lee, D.-S., & Jeon, Y.-J. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115195 · Cited by 102 · see citing works

Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14

Nadeau, S., & Rivest, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3370 · Cited by 94 · see citing works

Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll‐Like Receptor Agonists and Is Blocked by Hemopexin

Lin, T., Kwak, Y. H., Sammy, F., He, P., Thundivalappil, S., Sun, G., Chao, W., & Warren, H. S. (2010) · The Journal of Infectious Diseases · doi:10.1086/654929 · Cited by 91 · see citing works

Mast Cells in Allergic and Inflammatory Diseases

Sismanopoulos, N., Delivanis, D.-A., Alysandratos, K.-D., Angelidou, A., Therianou, A., Kalogeromitros, D., & C. Theoharides, T. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212800165997 · Cited by 87 · see citing works

Activated M2 Macrophages Contribute to the Pathogenesis of IgG4‐Related Disease via Toll‐like Receptor 7/Interleukin‐33 Signaling

Ishiguro, N., Moriyama, M., Furusho, K., Furukawa, S., Shibata, T., Murakami, Y., Chinju, A., Haque, A. S. M. R., Gion, Y., Ohta, M., et al. (2020) · Arthritis &amp; Rheumatology · doi:10.1002/art.41052 · Cited by 86 · see citing works

Contribution of Toll-like Receptor 9 Signaling to the Acute Inflammatory Response to Nonviral Vectors

Zhao, H., Hemmi, H., Akira, S., Cheng, S. H., Scheule, R. K., & Yew, N. S. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2003.11.012 · Cited by 85 · see citing works

The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases

Coutinho-Silva, R., Morandini, A., & Savio, L. B. (2014) · Biomedical Journal · doi:10.4103/2319-4170.127803 · Cited by 81 · see citing works

Interleukin-15 and the regulation of lymphoid homeostasis

Lodolce, J., Burkett, P., Koka, R., Boone, D., Chien, M., Chan, F., Madonia, M., Chai, S., & Ma, A. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00211-0 · Cited by 71 · see citing works

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-β production

Mahieu, T., Park, J. M., Revets, H., Pasche, B., Lengeling, A., Staelens, J., Wullaert, A., Vanlaere, I., Hochepied, T., van Roy, F., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510874103 · Cited by 70 · see citing works

Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro

Sodhi, A., Tarang, S., & Kesherwani, V. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2006.11.014 · Cited by 67 · see citing works

TLR2/TLR4 activation induces Tregs and suppresses intestinal inflammation caused by Fusobacterium nucleatum in vivo

Jia, Y.-P., Wang, K., Zhang, Z.-J., Tong, Y.-N., Han, D., Hu, C.-Y., Li, Q., Xiang, Y., Mao, X.-H., & Tang, B. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186179 · Cited by 65 · see citing works

Glial functions in the blood-brain communication at the circumventricular organs

Miyata, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.991779 · Cited by 66 · see citing works

Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis

Wiese, M. D., Manning-Bennett, A. T., & Abuhelwa, A. Y. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1752660 · Cited by 58 · see citing works

TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism

Jones, S. C., Brahmakshatriya, V., Huston, G., Dibble, J., & Swain, S. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901296 · Cited by 54 · see citing works

Innate immune sensing of adeno-associated virus vectors

Cao, D., Byrne, B. J., de Jong, Y. P., Terhorst, C., Duan, D., Herzog, R. W., & Kumar, S. R. P. (2024) · Human Gene Therapy · doi:10.1089/hum.2024.040 · Cited by 50 · see citing works

Preterm neonates display altered plasmacytoid dendritic cell function and morphology

Schüller, S. S., Sadeghi, K., Wisgrill, L., Dangl, A., Diesner, S. C., Prusa, A. R., Klebermasz-Schrehof, K., Greber-Platzer, S., Neumüller, J., Helmer, H., et al. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1011525 · Cited by 50 · see citing works

Differential regulation of endothelial cell activation by complement and interleukin 1α

Brunn, G. J., Saadi, S., & Platt, J. L. (2006) · Circulation Research · doi:10.1161/01.res.0000216071.87981.16 · Cited by 47 · see citing works

Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?

Wang, Y., Jia, J., Wang, Y., Li, F., Song, X., Qin, S., Wang, Z., Kitazato, K., & Wang, Y. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1660615 · Cited by 40 · see citing works

Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk

Kormann, M. S. D., Ferstl, R., Depner, M., Klopp, N., Spiller, S., Illig, T., Vogelberg, C., Von Mutius, E., Kirschning, C. J., & Kabesch, M. (2009) · Allergy · doi:10.1111/j.1398-9995.2008.01891.x · Cited by 39 · see citing works

Inflammation and chronic heart failure–potential therapeutic role of intravenous immunoglobulin

Aukrust, P., Yndestad, A., Damås, J. K., & Gullestad, L. (2004) · Autoimmunity Reviews · doi:10.1016/s1568-9972(03)00103-4 · Cited by 37 · see citing works

Genome-wide expression profiling of placentas in the p57Kip2 model of pre-eclampsia

Knox, K. S., & Baker, J. C. (2007) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gal116 · Cited by 33 · see citing works

Nicotine encourages oxidative stress and impairment of rats’ brain mitigated by Spirulina platensis lipopolysaccharides and low-dose ionizing radiation

Elsonbaty, S. M., & Ismail, A. F. M. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108382 · Cited by 32 · see citing works

Expression profiling and functional analysis of Toll‐like receptors in primary healthy human nasal epithelial cells shows no correlation and a refractory LPS response

van Tongeren, J., Röschmann, K. I. L., Reinartz, S. M., Luiten, S., Fokkens, W. J., de Jong, E. C., & van Drunen, C. M. (2015) · Clinical and Translational Allergy · doi:10.1186/s13601-015-0086-3 · Cited by 30 · see citing works