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Cited by 536Studies on Chitinases and ChitosanasesProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins Research

Chitinase-3 like-protein-1 function and its role in diseases

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Zhao, Ting, Su, Zhongping, Li, Yingchang, Zhang, Xiaoren, You, Qiang·2020·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-020-00303-7PMC PMC7490424
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Abstract

Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular matrix changes, cytokines, growth factors, drugs, and stress. CHI3L1 is synthesized and secreted by a multitude of cells including macrophages, neutrophils, synoviocytes, chondrocytes, fibroblast-like cells, smooth muscle cells, and tumor cells. It plays a major role in tissue injury, inflammation, tissue repair, and remodeling responses. CHI3L1 has been strongly associated with diseases including asthma, arthritis, sepsis, diabetes, liver fibrosis, and coronary artery disease. Moreover, following its initial identification in the culture supernatant of the MG63 osteosarcoma cell line, CHI3L1 has been shown to be overexpressed in a wealth of both human cancers and animal tumor models. To date, interleukin-13 receptor subunit alpha-2, transmembrane protein 219, galectin-3, chemo-attractant receptor-homologous 2, and CD44 have been identified as CHI3L1 receptors. CHI3L1 signaling plays a critical role in cancer cell growth, proliferation, invasion, metastasis, angiogenesis, activation of tumor-associated macrophages, and Th2 polarization of CD4+T cells. Interestingly, CHI3L1-based targeted therapy has been increasingly applied to the treatment of tumors including glioma and colon cancer as well as rheumatoid arthritis. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.

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Authors
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q.
Affiliations
  • Guangzhou Medical University (CN)
  • Second Affiliated Hospital of Nanjing Medical University (CN)
Corresponding author
You, Qiang
ORCID
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2020-09-14
Volume
5
Issue
1
Pages
201-201
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-020-00303-7
PMC
PMC7490424
OpenAlex
W3086455642
Cited by
536
References
6
Citations by year
2026: 58 · 2025: 122 · 2024: 127 · 2023: 106 · 2022: 81 · 2021: 39 · 2020: 3
FWCI
5.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81671543, 81870409)
  • Guangzhou key medical discipline construction project
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Keywords
YKL-40, glycoside hydrolase family 18, extracellular matrix, inflammation, tissue remodeling, asthma, arthritis, sepsis, liver fibrosis, coronary artery disease, cancer, metastasis, angiogenesis, tumor-associated macrophages, Th2 polarization, galectin-3, CD44, targeted therapy, glioma, colon cancer, rheumatoid arthritis
MeSH terms
Chitinase-3-Like Protein 1, Animals, Bone Neoplasms, Humans, Neoplasm Proteins, Organ Specificity, Osteosarcoma, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic

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