The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
Open accessAbstract
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs, targeted therapeutic drugs have become mainstream cancer treatments. Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration (FDA) in 2001, an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies. By December 2020, 89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration (NMPA) of China. Despite great progress, small-molecule targeted anti-cancer drugs still face many challenges, such as a low response rate and drug resistance. To better promote the development of targeted anti-cancer drugs, we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification. We present all the approved drugs as well as important drug candidates in clinical trials for each target, discuss the current challenges, and provide insights and perspectives for the research and development of anti-cancer drugs.
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Cites
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Self-citationThe Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics
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Metadata
- Authors
- Zhong, L., Li, Y., Xiong, L., Wang, W., Wu, M., Yuan, T., Yang, W., Tian, C., Miao, Z., Wang, T., & Yang, S.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2021-05-31
- Volume
- 6
- Issue
- 1
- Pages
- 201-201
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W3165143074
- Cited by
- 1,696
- References
- 68
- FWCI
- 148.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhong, L., Li, Y., Xiong, L., Wang, W., Wu, M., Yuan, T., Yang, W., Tian, C., Miao, Z., Wang, T., & Yang, S. (2021). Small molecules in targeted cancer therapy: advances, challenges, and future perspectives. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-021-00572-w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
