The DOI matches its Crossref record; 247 of the 247 references it cites were found in a registry or an index.
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
Open accessAbstract
Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biological and cellular processes, such as cell proliferation, growth, invasion, migration, and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is significantly associated with clinicopathological characteristics and plays an important role in the regulation of biological functions. In this review, we summarized the expression and biological functions of PI3K-AKT-related circRNAs in vitro and in vivo and assessed their associations with clinicopathological characteristics. We also further discussed the important role of circRNAs in the diagnosis, prognostication, and treatment of cancers.
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11 retracted
Zhang, X., Wang, S., Wang, H., Cao, J., Huang, X., Chen, Z., Xu, P., Sun, G., Xu, J., Lv, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0935-5 · Cited by 842
RetractedHu, S., Xu, Y., Teng, X., Fan, R., Jiang, T., Cao, M., Shi, L., & Song, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109941 · Cited by 72
RetractedRETRACTED: SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway
Xu, L., Chen, J., Jia, L., Chen, X., Moumin, F. A., & Cai, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16060 · Cited by 62
RetractedChen, T., Yu, Q., Lei, X., & Guo, L. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29296 · Cited by 40
RetractedZhang, X., Wang, D., Liu, B., Jin, X., Wang, X., Pan, J., Tu, W., & Shao, Y. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01657-0 · Cited by 38
RetractedMisra, U. K., & Pizzo, S. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088373 · Cited by 26
RetractedLi, J., Yang, Y., Xu, D., & Cao, L. (2021) · Cell Transplantation · doi:10.1177/0963689720975390 · Cited by 25
RetractedMa, N., Pan, J., Wen, Y., Wu, Q., Yu, B., Chen, X., Wan, J., & Zhang, W. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.008 · Cited by 25
RetractedLiu, Z., Hu, G., Zhao, Y., Xiao, Z., Yan, M., & Ren, M. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29458 · Cited by 19
Retracted[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218
Lin, E., Liu, S., Xiang, W. D., Zhang, H., & Xie, C. (2020) · BioMed Research International · doi:10.1155/2020/8386936 · Cited by 16
Retracted
Cited by
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Li, Y., Wang, Z., Gao, P., Cao, D., Dong, R., Zhu, M., Fei, Y., Zuo, X., & Cai, J. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05498-9 · Cited by 55
Metadata
- Authors
- Xue, C., Li, G., Lu, J., & Li, L.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2021-11-24
- Volume
- 6
- Issue
- 1
- Pages
- 400-400
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W3216513162
- Cited by
- 268
- References
- 247
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
