The DOI matches its Crossref record; 759 of the 759 references it cites were found in a registry or an index.
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions
Open accessAbstract
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.
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“These systems include scaffold-based models (for example, hydrogels 81 and electrospun fibers 82 ), microcarrier-grown cultures and free-floating neurospheres or aggregates maintained in spinner flasks or bioreactors 83 .”
Metadata
- Authors
- Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2024-07-01
- Volume
- 9
- Issue
- 1
- Pages
- 166-166
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4400174569
- Cited by
- 667
- References
- 759
- FWCI
- 70.64
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024). Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-024-01852-x
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