CoChat
Sign Up
Cited by 65Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsGastrointestinal Bleeding Diagnosis and Treatment

Characterization of Upper Gastrointestinal Symptoms, Gastric Motor Functions, and Associations in Patients with Diabetes at a Referral Center

Chedid, Victor, Brandler, Justin, Vijayvargiya, Priya, Park, Seon-Young, Szarka, Lawrence A., Camilleri, Michael·2019·American Journal of Gastroenterology
DOI 10.1038/s41395-018-0234-1
Open this paper in CoChat — free account

Abstract

OBJECTIVES: Our aim was to characterize upper gastrointestinal (UGI) symptoms and associations in individuals with diabetes mellitus (DM) who had undergone evaluation of gastric emptying (GE) and accommodation (GA) at a referral center. METHODS: From the Mayo Clinic Rochester electronic medical records of adults with diabetes types 1 and 2 (DM1 and DM2) evaluated between January 1997 and December 2015, we extracted demographics, UGI symptoms, current medications, treatments for diabetes, GE solids by scintigraphy, GA by single photon emission computed tomography (SPECT), and diabetes complications. We compared subgroups with delayed (GE at 2 h <25% or GE at 4 h <75%), rapid (GE at 1 h > 35%), and normal GE, as well as reduced (<428 mL) and normal GA. RESULTS: We reviewed 108 patients (60.2% females, median age 49.0 years). Overall, 71.3% had DM2; one-third of these were insulin dependent and had fairly well-controlled diabetes (median HbA1c 6.7% (IQR 6.2; 7.9)). Manifestations of diabetic triopathy (peripheral neuropathy, nephropathy, and retinopathy) were uncommon at presentation with UGI symptoms. Nausea was the most common symptom (80.6%). There were single or combined GE (total 56%: rapid in 37%, slow in 19%) and GA (total 39%) abnormalities; there was normal GA and GE in 28%; 40.3% of the DM2 patients had accelerated GE at 1 h. GE at 1 h is associated with nausea/vomiting, and fasting gastric volume is associated with bloating. CONCLUSIONS: Among referred diabetic patients with UGI symptoms, GE and GA testing identifies potential targets for individualizing treatment and avoidance of empirical trials for the 28% with no disturbance of GE and GA.

Integrity signals

Registry

Crossref · 10.1038/s41395-018-0234-1

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Continuous glucose monitoring (CGM) consistently reveals sharp oscillations, delayed peaks, and late postprandial waves of hyperglycaemia alternating with unpredictable hypoglycaemic drops.

    “Continuous glucose monitoring (CGM) consistently reveals sharp oscillations, delayed peaks, and late postprandial waves of hyperglycaemia alternating with unpredictable hypoglycaemic drops [97].”

    From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [97]

  • Diabetes can affect motility along the entire gut, producing gastroparesis often with antral hypomotility and pyloric dysfunction, rapid gastric emptying, impaired gastric accommodation, diarrhea, constipation, and fecal incontinence.

    “Diabetes can affect motility along the entire gut, producing gastroparesis (often with antral hypomotility and pyloric dysfunction), rapid gastric emptying, impaired gastric accommodation, diarrhea, constipation, and fecal incontinence (Camilleri et al., 2018; Chedid et al., 2019).”

    From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Chedid et al., 2019

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Chedid, V., Brandler, J., Vijayvargiya, P., Park, S.-Y., Szarka, L. A., & Camilleri, M.
Affiliations
Mayo Clinic (US)
Corresponding author
Camilleri, Michael
ORCID
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-01
Volume
114
Issue
1
Pages
143-154
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1038/s41395-018-0234-1
OpenAlex
W2888818644
Cited by
65
References
7
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 11 · 2019: 5 · 2018: 3 · 2017: 1
FWCI
8.57
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Mayo Clinic
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK115950)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Keywords
diabetes mellitus, upper gastrointestinal symptoms, gastric emptying, gastric accommodation, nausea, vomiting, bloating, type 2 diabetes, type 1 diabetes, diabetic gastroparesis, delayed gastric emptying, rapid gastric emptying, diabetes complications
MeSH terms
Adult, Diabetes Mellitus, Type 2, Female, Gastric Emptying, Humans, Male, Medical Records, Middle Aged, New York, Radionuclide Imaging, Referral and Consultation, Cohort Studies, Gastroparesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review