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Cited by 102Colorectal Cancer Screening and DetectionInflammatory Bowel DiseaseColorectal Cancer Surgical Treatments

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Strategies for Detecting Colorectal Cancer in Patients with Inflammatory Bowel Disease: A Cochrane Systematic Review and Meta-Analysis

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Bye, William A., Ma, Christopher, Nguyen, Tran M., Parker, Claire E., Jairath, Vipul, East, James E.·2018·American Journal of Gastroenterology
DOI 10.1038/s41395-018-0354-7PMC PMC6768584
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Abstract

OBJECTIVES: Patients with longstanding ulcerative colitis (UC) and colonic Crohn's disease (CD) have an increased risk of colorectal cancer (CRC). We assess the effectiveness of endoscopic surveillance in patients with inflammatory bowel disease (IBD) for diagnosing CRC and reducing CRC-related mortality. METHODS: MEDLINE, EMBASE, and CENTRAL were searched from inception to 19 September 2016. Randomized controlled trials (RCTs), observational cohorts, or case-control studies assessing any form of endoscopic surveillance for early CRC detection were eligible for inclusion; studies without a comparison non-surveillance group were excluded. The primary outcome was rate of CRC detection. Secondary outcomes were rate of early (Duke stage A and B) versus late (Duke stage C & D) CRC detection and rate of CRC-related death. Data were pooled using fixed or random effects models based on the degree of heterogeneity; pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the Mantel-Haenszel method. RESULTS: Five observational studies evaluating 7199 IBD patients were included; no RCTs met criteria for inclusion. There are limited new studies evaluating this clinical question (last included study published 2014). There was a significantly higher rate of cancer detection in the non-surveillance group (3.2%, 135/4256) compared to the surveillance group (1.8%, 53/2895) (OR 0.58 (95% CI: 0.42-0.80), p < 0.001). In four pooled studies, there was a significantly lower rate of CRC-associated death in the surveillance group (8.5%, 15/176) compared to the non-surveillance group (22.3%, 79/354) (OR 0.36 (95% CI: 0.19-0.69), p = 0.002). In two pooled studies, there was a significantly higher rate of early-stage CRC detection in the surveillance group (15.5%, 17/110) compared to the non-surveillance group (7.7%, 9/117) (OR 5.40 (95% CI: 1.51-19.30), p = 0.009). CONCLUSIONS: Colonoscopic surveillance in IBD is associated with a reduction in CRC development and CRC-associated death, as well as increased detection of early-stage CRC.

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  • In a meta-analysis, in the group of individuals with inflammatory bowel disease observed using colonoscopy, colorectal cancer occurred in 1.8% of patients, and in the group without colonoscopy in 3.2% of cases (P < 0.001).

    “The meta-analysis showed that in the group of individuals with IBD observed using colonoscopy, CRC occurred in 1.8% of patients, and in the group without colonoscopy in 3.2% of cases (P < 0.001)[45].”

    From Risk factors, prevention and screening of colorectal cancer: A rising problem (2025) · cites this paper as [45]

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Metadata

Authors
Bye, W. A., Ma, C., Nguyen, T. M., Parker, C. E., Jairath, V., & East, J. E.
Affiliations
Western University (CA)
Corresponding author
East, James E.
ORCID
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-12
Volume
113
Issue
12
Pages
1801-1809
ISSN
0002-9270 (ISSN-L)
DOI
10.1038/s41395-018-0354-7
PMC
PMC6768584
OpenAlex
W2896714736
Cited by
102
References
1
Citations by year
2026: 7 · 2025: 12 · 2024: 12 · 2023: 20 · 2022: 22 · 2021: 12 · 2020: 11 · 2019: 4 · 2018: 2
FWCI
0.76
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute for Health and Care Research
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords
colorectal cancer, inflammatory bowel disease, ulcerative colitis, Crohn's disease, endoscopic surveillance, cancer detection, early colorectal cancer, colorectal cancer mortality, surveillance interval
MeSH terms
Colitis, Ulcerative, Colon, Colonoscopy, Crohn Disease, Humans, Mortality, Neoplasm Staging, Rectum, Colorectal Neoplasms, Incidence, Randomized Controlled Trials as Topic, Early Detection of Cancer, Observational Studies as Topic

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