Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies
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Chronic inflammation and flares of disease are risk factors for CAC.
“In agreement with this link, chronic inflammation and flares of disease have been identified as risk factors for CAC.37–39”
From PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells (2022) · cites this paper as [37]
The Discussion (page not provided) identifies severity of colonic inflammation as a determinant of colorectal neoplasia risk in ulcerative colitis and says ongoing, extensive inflammation might increase colorectal cancer risk. It does not identify disease flares as a separate risk factor, so that part of the claim is unsupported by this copy. (LLM, conf=0.87)
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- Authors
- Jess, T., Rungoe, C., & Peyrin–Biroulet, L.
- Affiliations
- Statens Serum Institut (DK)
- Corresponding author
- Jess, Tine
- ORCID
- Jess, Tine
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 10
- Issue
- 6
- Pages
- 639-645
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2014776577
- Cited by
- 958
- References
- 0
- Citations by year
- 2026: 51 · 2025: 78 · 2024: 56 · 2023: 74 · 2022: 80 · 2021: 89 · 2020: 83 · 2019: 75 · 2018: 72 · 2017: 56 · 2016: 61 · 2015: 56 · 2014: 58 · 2013: 51 · 2012: 16
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Keywords
- ulcerative colitis, colorectal cancer, cancer risk, standardized incidence ratio, sex differences, age at diagnosis, extensive colitis, proctitis, colectomy, inflammatory bowel disease
- MeSH terms
- Age Factors, Colitis, Ulcerative, Female, Humans, Male, Sex Factors, Colorectal Neoplasms, Cohort Studies, Incidence, Risk Assessment
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