Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits
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Abstract Animal studies indicate that substance P (SP) and its preferred neurokinin-1 (NK1) receptor modulate stress and anxiety-related behavior. Alterations in the SP-NK1 system have also been observed in human anxiety disorders, yet little is known about the relation between this system and individual differences in personality traits associated with anxiety propensity and approach-avoidance behavior, including trait anxiety, neuroticism, and extraversion. Exploring this relation could provide important insights into the neurobiological underpinnings of human anxiety and the etiology of anxiety disorders, as anxious traits are associated with increased susceptibility to develop psychopathological conditions. Here we examined the relationship between central NK1 receptor availability and self-rated measures of trait anxiety, neuroticism, and extraversion. The amygdala was chosen as the primary region of interest since this structure has been suggested to mediate the effect of the SP-NK1 system on anxiety. Anxious traits and NK1 receptor availability, determined with positron emission tomography and the radiotracer [11C]GR205171, were measured in 17 healthy individuals. Voxel-wise analyses showed a significant positive correlation between bilateral amygdala NK1 receptor availability and trait anxiety, and a trend in similar direction was observed for neuroticism. Conversely, extraversion was found to be negatively associated with amygdala NK1 receptor availability. Extraversion also correlated negatively with the NK1 measure in the cuneus/precuneus and fusiform gyrus according to exploratory whole-brain analyses. In conclusion, our findings indicate that amygdala NK1 receptor availability is associated with anxiety-related personality traits in healthy subjects, consistent with a modulatory role for the SP-NK1 system in human anxiety.
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There is a positive correlation between neurokinin 1 receptor expression in the amygdala and trait anxiety.
“Nevertheless, the recent finding that there is a positive correlation between neurokinin 1 receptor expression in the amygdala and trait anxiety, could stimulate further research on neurokinin 1 receptor antagonists as potential anxiolytics, at least for specific subpopulations of patients (Hoppe et al., 2018).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Hoppe et al., 2018
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- Authors
- Hoppe, J. M., Frick, A., Åhs, F., Linnman, C., Appel, L., Jonasson, M., Lubberink, M., Långström, B., Frans, Ö., von Knorring, L., Fredrikson, M., & Furmark, T.
- Affiliations
- Uppsala University (SE)
- Boston Children's Hospital (US)
- Corresponding author
- Hoppe, Johanna M.
- ORCID
- Venue
- Translational Psychiatry
- Published
- 2018-08-28
- Volume
- 8
- Issue
- 1
- Pages
- 168-168
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC6113290
- OpenAlex
- W2889011379
- Cited by
- 18
- References
- 68
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 3
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Diva portal (Dalarna University Library) (submittedVersion, other-oa)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Vetenskapsrådet
- Riksbankens Jubileumsfond
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- neurokinin-1 receptor, substance P, amygdala, trait anxiety, neuroticism, extraversion, personality traits, receptor availability, anxiety-like behavior, individual differences
- MeSH terms
- Adult, Amygdala, Anxiety, Female, Humans, Male, Personality, Piperidines, Regression Analysis, Tetrazoles, Receptors, Neurokinin-1, Positron-Emission Tomography, Healthy Volunteers, Neurokinin-1 Receptor Antagonists
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