The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions
Open accessAbstract
Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration, a significant contributor to LBP. Inflammatory mediators also play an indispensable role in discogenic LBP. The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies. Here, an overview of the advances in inflammation-related pain in disc degeneration is provided, with a discussion on the role of inflammation in IVD degeneration and pain induction. Puncture models, mechanical models, and spontaneous models as the main animal models to study painful disc degeneration are discussed, and the underlying signaling pathways are summarized. Furthermore, potential drug candidates, either under laboratory investigation or undergoing clinical trials, to suppress discogenic LBP by eliminating inflammation are explored. We hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research.
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2 retracted
Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro
Li, X., Lin, F.-X., Wu, Y., Liu, N., Wang, J., Chen, R., & Lu, Z. (2019) · Bioscience Reports · doi:10.1042/bsr20190126 · Cited by 55
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RetractedDouble-slit photoelectron interference in strong-field ionization of the neon dimer
Kunitski, M., Eicke, N., Huber, P., Köhler, J., Zeller, S., Voigtsberger, J., Schlott, N., Henrichs, K., Sann, H., Trinter, F., et al. (2019) · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · doi:10.15488/5174 · Cited by 8,161
What low back pain is and why we need to pay attention
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Toll-like receptors in innate immunity
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Signal integration by JNK and p38 MAPK pathways in cancer development
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Prevention and treatment of low back pain: evidence, challenges, and promising directions
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“This condition is now the number one cause of the world’s disability burden.(4) Recurrent LBP impairs the patient’s physical and mental health and places a heavy burden on health care and social support systems.”
BackgroundWhat is Intervertebral Disc Degeneration, and What Causes It?
Adams, M. A., & Roughley, P. J. (2006) · Spine · doi:10.1097/01.brs.0000231761.73859.2c · Cited by 1,780
Cited by
Mohd Isa, I. L., Teoh, S. L., Mohd Nor, N. H., & Mokhtar, S. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010208 · Cited by 365
Zhang, W., Li, G., Luo, R., Lei, J., Song, Y., Wang, B., Ma, L., Liao, Z., Ke, W., Liu, H., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00729-9 · Cited by 325
MiR-30 family: a novel avenue for treating bone and joint diseases?
Huang, J., Li, Y., Zhu, S., Wang, L., Yang, L., & He, C. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.81990 · Cited by 23
Metadata
- Authors
- Lyu, F.-J., Cui, H., Pan, H., MC Cheung, K., Cao, X., Iatridis, J. C., & Zheng, Z.
- Venue
- Bone Research
- Published
- 2021-01-29
- Volume
- 9
- Issue
- 1
- Pages
- 7-7
- ISSN
- 2095-4700 (ISSN-L)
- 2095-6231
- OpenAlex
- W3125740254
- Cited by
- 474
- References
- 147
- FWCI
- 43.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lyu, F.-J., Cui, H., Pan, H., MC Cheung, K., Cao, X., Iatridis, J. C., & Zheng, Z. (2021). Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions. Bone Research. https://doi.org/10.1038/s41413-020-00125-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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