MiR-30 family: a novel avenue for treating bone and joint diseases?
Open accessAbstract
Bone and joint diseases are a group of clinically heterogeneous diseases characterized by various bone strength disorders, bone structural defects and bone mass abnormalities. Common bone diseases include osteoporosis, skeletal dysplasia, and osteosarcoma, and common joint diseases include osteoarthritis, rheumatoid arthritis, and degenerative disc disease. all of them lead to high medical costs. The miR-30 family consists of a total of 5 members: miR-30a, miR-30b, miR-30c, miR-30d and miR-30e. Accumulating evidence has indicated that the miR-30 family may be involved in the occurrence and development of bone and joint diseases. For example, miR-30a is highly expressed in blood samples of osteoporosis patients, miR-30a/b increases in cartilage tissue of osteoarthritis patients, and lower expression of miR-30c is associated with higher malignance and shorter survival time of osteosarcoma. Mechanistically, by targeting crucial transcription factors (RUNX2, SOX9, beclin-1, etc.), the miR-30 family regulates some critical pathways of bone homeostasis (Wnt/β-Catenin, mTOR, PI3K/AKT, etc.). In view of the distinct actions of the miR-30 family on bone metabolism, we hypothesize that the miR-30 family may be a new remedy for the clinical treatment and prevention of some bone and joint diseases.
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MSC-Exos reduces the expression of proinflammatory cytokines in immune cells, diminishing inflammation-induced delays in bone healing and promoting bone tissue regeneration.
“Furthermore, MSC-Exos reduces the expression of proinflammatory cytokines in immune cells, thereby diminishing inflammation-induced delays in bone healing and promoting bone tissue regeneration [25,26].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [25]
The 'MiR-30 Family and Extracellular Vesicles of Different Origins' section discusses BMSC-derived vesicles in osteosarcoma and vesicles from other sources in arthritis, but does not report the claimed effect of MSC exosomes. Searches for cytokines in immune cells and inflammation-related delays in bone healing found no passage addressing that claim. Page numbers were not provided in our copy. (LLM, conf=0.75)
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Xu, Y., Yao, T., Huang, K., et al. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2 · see citing works
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Si, Y., Li, X., Dong, S., Gao, X., Zhu, Y., Mo, L., Wang, Z., Wang, S., & Zhang, C. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.026 · Cited by 17 · see citing works
“Furthermore, MSC-Exos reduces the expression of proinflammatory cytokines in immune cells, thereby diminishing inflammation-induced delays in bone healing and promoting bone tissue regeneration [25,26].”
- Authors
- Huang, J., Li, Y., Zhu, S., Wang, L., Yang, L., & He, C.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Yang, Lin
- He, Chengqi
- Venue
- International Journal of Medical Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2023
- Volume
- 20
- Issue
- 4
- Pages
- 493-504
- ISSN
- 1449-1907 (ISSN-L)
- PMC
- PMC10087628
- OpenAlex
- W4320502761
- Cited by
- 23
- References
- 106
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- International Journal of Medical Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (hx-h2107188, 81972146, 81902287, 2021YFS0004)
- Department of Science and Technology of Sichuan Province (2021YFS0004)
- Sichuan University (81972146, 2021YFS0004, 81902287, hx-h2107188)
- West China Hospital, Sichuan University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- miR-30 family, bone and joint diseases, osteoporosis, osteoarthritis, rheumatoid arthritis, intervertebral disc degeneration, osteosarcoma, skeletal dysplasia, miR-30a, miR-30c, miR-30d, miR-30e, bone homeostasis, Wnt/β-catenin signaling, mTOR signaling, PI3K/Akt signaling, Runx2, SOX9, Beclin-1, microRNA therapeutic target
- MeSH terms
- Bone Neoplasms, Humans, Osteoarthritis, Osteoporosis, Osteosarcoma, Phosphatidylinositol 3-Kinases, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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