The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis
Open accessAbstract
Diabetic osteoporosis (DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1 (HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
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Ferroptosis as a target for protection against cardiomyopathy
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Nrf2-Keap1 signaling in oxidative and reductive stress
Bellezza, I., Giambanco, I., Minelli, A., & Donato, R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.02.010 · Cited by 2,053
Recent Progress in Ferroptosis Inducers for Cancer Therapy
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Energy-stress-mediated AMPK activation inhibits ferroptosis
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Mechanisms of diabetes mellitus-induced bone fragility
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The Osteocyte: An Endocrine Cell … and More
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Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
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Cited by
Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
Metadata
- Authors
- Yang, Y., Lin, Y., Wang, M., Yuan, K., Wang, Q., Mu, P., Du, J., Yu, Z., Yang, S., Huang, K., Wang, Y., Li, H., & Tang, T.
- Venue
- Bone Research
- Published
- 2022-03-09
- Volume
- 10
- Issue
- 1
- Pages
- 26-26
- ISSN
- 2095-4700 (ISSN-L)
- 2095-6231
- OpenAlex
- W4220780172
- Cited by
- 259
- References
- 47
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yang, Y., Lin, Y., Wang, M., Yuan, K., Wang, Q., Mu, P., Du, J., Yu, Z., Yang, S., Huang, K., Wang, Y., Li, H., & Tang, T. (2022). Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis. Bone Research. https://doi.org/10.1038/s41413-022-00198-w
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