The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
Open accessAbstract
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. The vertebrate Nrf2 belongs to Cap 'n' Collar (Cnc) bZIP family of transcription factors and shares a high homology with SKN-1 from Caenorhabditis elegans or CncC found in Drosophila melanogaster. The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. On the other hand, the disturbances in the proper HO-1 level are associated with the pathogenesis of some age-dependent disorders, including neurodegeneration, cancer or macular degeneration. This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors.
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Citations
Cites
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630
Nrf2–Keap1 defines a physiologically important stress response mechanism
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The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
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“The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding seq…”
BackgroundMechanisms of Cell Protection by Heme Oxygenase-1
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Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
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Stress-activated cap’n’collar transcription factors in aging and human disease
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“NF-E2 p45-related factors 1 and 3 (Nrf1 and Nrf3) as well as transcriptional repressors Bach1 and Bach2 are the members of the family (reviewed in [4]).”
BackgroundCoordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
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Cited by
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
Singh, R., Chandrashekharappa, S., Bodduluri, S. R., Baby, B. V., Hegde, B., Kotla, N. G., Hiwale, A. A., Saiyed, T., Patel, P., Vijay-Kumar, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07859-7 · Cited by 713
Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis
Chang, L.-C., Chiang, S.-K., Chen, S.-E., Yu, Y.-L., Chou, R.-H., & Chang, W.-C. (2018) · Cancer Letters · doi:10.1016/j.canlet.2017.12.025 · Cited by 521
Sun, Y.-Y., Zhu, H.-J., Zhao, R.-Y., Zhou, S.-Y., Wang, M.-Q., Yang, Y., & Guo, Z.-N. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102852 · Cited by 279
Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11
Dong, H., Xia, Y., Jin, S., Xue, C., Wang, Y., Hu, R., & Jiang, H. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04307-1 · Cited by 196
Tanaka, M., Kishimoto, Y., Sasaki, M., Sato, A., Kamiya, T., Kondo, K., & Iida, K. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9364364 · Cited by 154
Metadata
- Authors
- Loboda, A., Damulewicz, M., Pyza, E., Jozkowicz, A., & Dulak, J.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-04-21
- Volume
- 73
- Issue
- 17
- Pages
- 3221-3247
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2340338776
- Cited by
- 2,632
- References
- 22
- FWCI
- 64.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Loboda, A., Damulewicz, M., Pyza, E., Jozkowicz, A., & Dulak, J. (2016). Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-016-2223-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
