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Cited by 178Cellular transport and secretionMechanisms of cancer metastasisCaveolin-1 and cellular processes

Endocytosis: a pivotal pathway for regulating metastasis

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Khan, Imran, Steeg, Patricia S.·2021·British Journal of Cancer
DOI 10.1038/s41416-020-01179-8PMC PMC7782782
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Abstract

A potentially important aspect in the regulation of tumour metastasis is endocytosis. This process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or receptor-mediated endocytosis, the latter of which includes clathrin-, caveolae- and non-clathrin or caveolae-mediated mechanisms. Endocytosis then progresses through several intracellular compartments for sorting and routing of cargo, ending in lysosomal degradation, recycling back to the cell surface or secretion. Multiple endocytic proteins are dysregulated in cancer and regulate tumour metastasis, particularly migration and invasion. Importantly, four metastasis suppressor genes function in part by regulating endocytosis, namely, the NME, KAI, MTSS1 and KISS1 pathways. Data on metastasis suppressors identify a new point of dysregulation operative in tumour metastasis, alterations in signalling through endocytosis. This review will focus on the multicomponent process of endocytosis affecting different steps of metastasis and how metastatic-suppressor genes use endocytosis to suppress metastasis.

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Crossref · 10.1038/s41416-020-01179-8

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  • Metastatic suppressor genes KISS1 and MTSS1 activity depends on alteration in the endocytosis process.

    “There are some metastatic suppressor genes such as Kisspeptin-1 (KISS1), and metastasis suppressor protein 1 (MTSS1) whose activity depends on alteration in the endocytosis process [106].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [106]

    The Abstract identifies MTSS1 and KISS1 among metastasis suppressor pathways that function in part by regulating endocytosis, and the ‘Metastasis suppressors and endocytosis’ section describes genes working through alterations in endocytosis. The claim’s assertion that their activity depends on those alterations is stronger than the source’s qualified account. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • In head and neck squamous cell carcinoma, a low level of MTSS1 augments EGF signaling and induces cell proliferation.

    “However, in head and neck squamous cell carcinoma, a low level of MTSS1 augment the EGF signaling and induce cell proliferation [106].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [106]

    The MTSS1 section says that MTSS1 augments EGF signalling and promotes proliferation in head and neck squamous cell carcinoma at low cell densities. The claim changes that condition to a low level of MTSS1, which the passage does not support. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Endocytosis appears as an important regulator of tumor metastasis.

    “Endocytosis appears as an important regulator of tumor metastasis [106].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [106]

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Authors
Khan, I., & Steeg, P. S.
Affiliations
  • National Institutes of Health (US)
  • National Cancer Institute (US)
Corresponding author
Khan, Imran
ORCID
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
2020-12-02
Volume
124
Issue
1
Pages
66-75
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/s41416-020-01179-8
PMC
PMC7782782
OpenAlex
W3107474402
Cited by
178
References
3
Citations by year
2026: 20 · 2025: 45 · 2024: 36 · 2023: 37 · 2022: 28 · 2021: 12
FWCI
2.24
Type
journal article
Language
en
Open access
Licence
Locations
  • British Journal of Cancer (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Institutes of Health intramural Funding
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
endocytosis, tumour metastasis, metastasis suppressor gene, receptor-mediated endocytosis, clathrin-mediated endocytosis, caveolae-mediated endocytosis, lysosomal degradation, cell migration, cell invasion, endocytic proteins
MeSH terms
Cell Movement, Endocytosis, Humans, Neoplasm Invasiveness, Neoplasms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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