ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein

Boulay, P-L; Schlienger, S; Lewis-Saravalli, S; Vitale, N; Ferbeyre, G; Claing, A

doi:10.1038/onc.2011.100

Cited by 62Cancer-related Molecular PathwaysCellular transport and secretionProtein Kinase Regulation and GTPase Signaling

ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein

Boulay, P-L, Schlienger, S, Lewis-Saravalli, S, Vitale, N, Ferbeyre, G, Claing, A·2011·Oncogene

DOI 10.1038/onc.2011.100

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Abstract

The ADP-ribosylation factors (ARFs) 1 and 6 are small GTP-binding proteins, highly expressed and activated in several breast cancer cell lines and are associated with enhanced migration and invasiveness. In this study, we report that ARF1 has a critical role in cell proliferation. Depletion of this GTPase or expression of a dominant negative form, which both resulted in diminished ARF1 activity, led to sustained cell-growth arrest. This cellular response was associated with the induction of senescent markers in highly invasive breast cancer cells as well as in control mammary epithelial cells by a mechanism regulating retinoblastoma protein (pRB) function. When examining the role of ARF1, we found that this GTPase was highly activated in normal proliferative conditions, and that a limited amount could be found in the nucleus, associated with the chromatin of MDA-MB-231 cells. However, when cells were arrested in the G(0)/G(1) phase or transfected with a dominant negative form of ARF1, the total level of activated ARF1 was markedly reduced and the GTPase significantly enriched in the chromatin. Using biochemical approaches, we demonstrated that the GDP-bound form of ARF1 directly interacted with pRB, but not other members of this family of proteins. In addition, depletion of ARF1 or expression of ARF1T(31)N resulted in the constitutive association of pRB and E2F1, thereby stabilizing the interaction of E2F1 as well as pRB at endogenous sites of target gene promoters, preventing expression of E2F target genes, such as cyclin D1, Mcm6 and E2F1, important for cell-cycle progression. These novel findings provide direct physiological and molecular evidence for the role of ARF1 in controlling cell proliferation, dependent on its ability to regulate pRB/E2F1 activity and gene expression for enhanced proliferation and breast cancer progression.

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Endosomal trafficking protein ARF1 regulates breast cancer cell proliferation and migration through regulating interaction of β1 integrin and focal adhesion proteins.
“Endosomal trafficking proteins such as ARF1 regulate breast cancer cell proliferation and migration through regulating the interaction of β1 integrin and protein of focal adhesion (paxillin, Fak, talin) [112,113].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [112]

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ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2
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A Retinoblastoma Allele That Is Mutated at Its Common E2F Interaction Site Inhibits Cell Proliferation in Gene-Targeted Mice
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Authors: Boulay, P.-L., Schlienger, S., Lewis-Saravalli, S., Vitale, N., Ferbeyre, G., & Claing, A.
Affiliations: Université de Montréal (CA)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Claing, A
ORCID: Schlienger, S
Vitale, N
Ferbeyre, G
Claing, A
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2011-04-11
Volume: 30
Issue: 36
Pages: 3846-3861
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/onc.2011.100
OpenAlex: W2062349989
Cited by: 61
References: 62
Citations by year: 2026: 2 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 6
FWCI: 2.04
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Canadian Institutes of Health Research (MOP-79470)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: Arf1, ADP-ribosylation factor, breast cancer, cell proliferation, retinoblastoma protein, E2F1, cell cycle regulation, cellular senescence, G proteins, chromatin association, cyclin D1, MCM6, dominant-negative mutant, G0/G1 arrest
MeSH terms: Animals, Breast Neoplasms, Cell Cycle, Chlorocebus aethiops, Female, Humans, Models, Biological, Retinoblastoma, Gene Expression Regulation, Neoplastic, Retinoblastoma Protein, Cellular Senescence, COS Cells, ADP-Ribosylation Factor 1, Cell Line, Tumor, Cell Proliferation, E2F1 Transcription Factor

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ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein

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