Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients
Open accessAbstract
Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum-tumor axis, influencing clinical outcome.
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Ileal immunocyte abundance was inversely correlated with the colon cancer immunoscore, which indicates good prognosis.
“The abundance of ileal immunocytes negatively correlated with the colon cancer 'immunoscore', which reflects good prognosis 33”
From Impact of the ONCOBIOME network in cancer microbiome research (2025) · cites this paper as [33]
16S sequencing of mucosal ileal and colonic microbiota showed profound taxonomic differences and allowed correlations with the transcriptome from ilea and colons.
“Ribosomal RNA (16S) sequencing of the mucosal ileal and colonic microbiota revealed profound taxonomic differences and enabled correlations with the transcriptome from ilea and colons 30,33”
From Impact of the ONCOBIOME network in cancer microbiome research (2025) · cites this paper as [33]
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- Authors
- Picard, M., Yonekura, S., Slowicka, K., Petta, I., Rauber, C., Routy, B., Richard, C., Iebba, V., Tidjani Alou, M., Becharef, S., Ly, P., Pizzato, E., Lehmann, C. H. K., Amon, L., Klein, C., Opolon, P., Gomperts Boneca, I., Scoazec, J.-Y., Hollebecque, A., Malka, D., Ghiringhelli, F., Dudziak, D., Berx, G., Vereecke, L., van Loo, G., Kroemer, G., Zitvogel, L., & Roberti, M. P.
- Affiliations
- Inserm (FR)
- Ghent University (BE)
- Centre Georges François Leclerc (FR)
- University of Trieste (IT)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Institut Gustave Roussy (FR)
- Karolinska University Hospital (SE)
- ORCID
- Picard, Marion
- Yonekura, Satoru
- Rauber, Conrad
- Routy, Bertrand
- Richard, Corentin
- Iebba, Valerio
- Becharef, Sonia
- Ly, Pierre
- Lehmann, Christian H. K.
- Amon, Lukas
- Klein, Christophe
- Opolon, Paule
- Gomperts Boneca, Ivo
- Scoazec, Jean-Yves
- Hollebecque, Antoine
- Malka, David
- Ghiringhelli, François
- Dudziak, Diana
- Berx, Geert
- Vereecke, Lars
- van Loo, Geert
- Kroemer, Guido
- Zitvogel, Laurence
- Venue
- Cell Death & Differentiation
- Published
- 2020-12-01
- Volume
- 28
- Issue
- 5
- Pages
- 1532-1547
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC8167112
- OpenAlex
- W3110367856
- Cited by
- 24
- References
- 40
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cell Death and Differentiation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, cc-by)
- Funders
- Association pour la Recherche sur le Cancer
- E-Rare
- European Commission
- Agence Nationale de la Recherche (ANR‐19, ANR-19-CE15-0029, ANR-16, E-Rare-2, ANR-16-RHUS-0008)
- Fondation Leducq
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Institut Universitaire de France
- Institut National Du Cancer
- Chancellerie des Universités de Paris
- Horizon 2020 Framework Programme
- Labex Immuno-Oncology
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- right-sided colon cancer, prognostic factors, oxaliplatin, chemotherapy response, epithelial apoptosis, gut microbiota, tumor surveillance, Th17 cells, ileal inflammation, carcinogenesis
- MeSH terms
- Animals, Colonic Neoplasms, Humans, Ileal Diseases, Ileum, Prognosis, Mice
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