The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion
Open accessAbstract
Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent differentiation capacities, have been used for many diseases treatment through regulation microenvironment. Numerous studies reported that MSCs transplantation could largely improve cutaneous wound healing via paracrine secretion of growth factors. However, whether MSCs take part in the angiogenesis process directly remains elusive. Previous study proved that autophagy inhibited immunosuppressive function of MSCs and prevented the degradation of MSCs function in inflammatory and senescent microenvironment. Here, we proved that autophagy determines the therapeutic effect of MSCs in cutaneous wound healing through promoting endothelial cells angiogenesis and demonstrated that the paracrine of vascular endothelial growth factor (VEGF) in MSCs was required in wound site. We further revealed that autophagy enhanced the VEGF secretion from MSCs through ERK phosphorylation directly. Collectively, we put forward that autophagy mediated paracrine of VEGF plays a central role in MSCs cured cutaneous wound healing and may provide a new therapeutic method for angiogenesis-related diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Arriola Apelo, S. I., Neuman, J. C., Baar, E. L., Syed, F. A., Cummings, N. E., Brar, H. K., Pumper, C. P., Kimple, M. E., & Lamming, D. W. (2016) · Aging Cell · doi:10.1111/acel.12405 · Cited by 182
Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells
Vázquez, P., Arroba, A. I., Cecconi, F., de la Rosa, E. J., Boya, P., & De Pablo, F. (2012) · Autophagy · doi:10.4161/auto.8.2.18535 · Cited by 171
Cited by
Guan, Y., Niu, H., Liu, Z., Dang, Y., Shen, J., Zayed, M., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 631
Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements
Kolimi, P., Narala, S., Nyavanandi, D., Youssef, A. A. A., & Dudhipala, N. (2022) · Cells · doi:10.3390/cells11152439 · Cited by 585
Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Nourian Dehkordi, A., Mirahmadi Babaheydari, F., Chehelgerdi, M., & Raeisi Dehkordi, S. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 533
Recent advances in molecular mechanisms of skin wound healing and its treatments
Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395479 · Cited by 284
Liang, L., Hui, K., Hu, C., Wen, Y., Yang, S., Zhu, P., Wang, L., Xia, Y., Qiao, Y., Sun, W., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1093-3 · Cited by 187
Metadata
- Authors
- An, Y., Liu, W. J., Xue, P., Ma, Y., Zhang, L. Q., Zhu, B., Qi, M., Li, L. Y., Zhang, Y. J., Wang, Q. T., & Jin, Y.
- Venue
- Cell Death & Disease
- Published
- 2018-01-19
- Volume
- 9
- Issue
- 2
- Pages
- 58-58
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2789268442
- Cited by
- 200
- References
- 4
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion. https://app.cochat.ai/papers/10.1038/s41419-017-0082-8
- The paper
- An, Y., Liu, W. J., Xue, P., Ma, Y., Zhang, L. Q., Zhu, B., Qi, M., Li, L. Y., Zhang, Y. J., Wang, Q. T., & Jin, Y. (2018). Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion. Cell Death & Disease. https://doi.org/10.1038/s41419-017-0082-8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
