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Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness

Llarena, N. C., & Hine, C. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa204 · Cited by 68 · see citing works

Current Approaches and Future Directions for the Treatment of mTORopathies

Karalis, V., & Bateup, H. S. (2021) · Developmental Neuroscience · doi:10.1159/000515672 · Cited by 67 · see citing works

Hypothalamic mTORC2 is essential for metabolic health and longevity

Chellappa, K., Brinkman, J. A., Mukherjee, S., Morrison, M., Alotaibi, M., Carbajal, K. A., Alhadeff, A. L., Perron, I. J., Yao, R., Purdy, C. S., et al. (2019) · Aging Cell · doi:10.1111/acel.13014 · Cited by 65 · see citing works

Novel strategies for anti-aging drug discovery

Saraswat, K., & Rizvi, S. I. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1349750 · Cited by 66 · see citing works

mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?

Kezić, A., Popović, L., & Lalic, K. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2640342 · Cited by 67 · see citing works

Rapamycin in ischemic stroke: Old drug, new tricks?

Hadley, G., Beard, D. J., Couch, Y., Neuhaus, A., Adriaanse, B. A., DeLuca, G., Sutherland, B. A., & Buchan, A. (2018) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x18807309 · Cited by 53 · see citing works

Off-Label Use of Sirolimus and Everolimus in a Pediatric Center: A Case Series and Review of the Literature

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Energetic interventions for healthspan and resiliency with aging

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Localised intravascular coagulation complicating venous malformations in children: Associations and therapeutic options

Zhuo, K. Y., Russell, S., Wargon, O., & Adams, S. E. (2017) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.13461 · Cited by 55 · see citing works

Next generation strategies for geroprotection via mTORC1 inhibition.

Dumas, S., & Lamming, D. (2019) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/glz056 · Cited by 38 · see citing works

Sirolimus as a new drug to treat RIF patients with elevated Th17/Treg ratio: A double-blind, phase II randomized clinical trial

Ahmadi, M., Abdolmohammadi‐Vahid, S., Ghaebi, M., Dolati, S., Abbaspour‐Aghdam, S., Danaii, S., Berjis, K., Madadi-Javid, R., Nouri, Z., Siahmansouri, H., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105730 · Cited by 47 · see citing works

Effects of rapamycin on growth hormone receptor knockout mice

Fang, Y., Hill, C. M., Darcy, J., Reyes‐Ordoñez, A., Arauz, E. J., McFadden, S., Zhang, C., Osland, J. M., Gao, J., Zhang, T., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717065115 · Cited by 46 · see citing works

TOR Signaling Pathway in Cardiac Aging and Heart Failure

Daneshgar, N., Rabinovitch, P. S., & Dai, D. (2021) · Biomolecules · doi:10.3390/biom11020168 · Cited by 44 · see citing works

Longevity‐related molecular pathways are subject to midlife “switch” in humans

Timmons, J. A., Volmar, C., Crossland, H., Phillips, B. E., Sood, S., Janczura, K. J., Törmäkangas, T., Kujala, U. M., Kraus, W. E., Atherton, P. J., et al. (2019) · Aging Cell · doi:10.1111/acel.12970 · Cited by 43 · see citing works

Phytosomes: emergent promising nano vesicular drug delivery system for targeted tumor therapy

Nazeer, A. A., Deepa, V. S., & Sivapriya, V. (2018) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6254/aadc50 · Cited by 40 · see citing works

The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies

Beard, D. J., Hadley, G., Thurley, N., Howells, D., Sutherland, B. A., & Buchan, A. (2018) · International Journal of Stroke · doi:10.1177/1747493018816503 · Cited by 34 · see citing works

mTOR‐mediated autophagy in the hippocampus is involved in perioperative neurocognitive disorders in diabetic rats

Chen, X., Gao, F., Lin, C., Chen, A., Deng, J., Chen, P., Lin, M., Xie, B., Liao, Y., Gong, C., et al. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13762 · Cited by 37 · see citing works

Immunologic and dose dependent effects of rapamycin and its evolving role in chemoprevention

O’Shea, A. E., Valdera, F. A., Ensley, D. C., Smolinsky, T. R., Cindass, J. L., Bohan, P. M. K., Hickerson, A. T., Carpenter, E. L., McCarthy, P. M., Adams, A. M., et al. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109095 · Cited by 39 · see citing works

Codelivery of Paclitaxel and Everolimus at the Optimal Synergistic Ratio: A Promising Solution for the Treatment of Breast Cancer

Houdaihed, L., Evans, J. C., & Allen, C. J. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00217 · Cited by 37 · see citing works

Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

Apelo, S. I. A., Lin, A., Brinkman, J. A., Meyer, E. J., Morrison, M., Tomasiewicz, J. L., Pumper, C. P., Baar, E. L., Richardson, N. E., Alotaibi, M., et al. (2020) · eLife · doi:10.7554/elife.56177 · Cited by 37 · see citing works

Metabolic Signaling Cascades Prompted by Glutaminolysis in Cancer

Shah, R., & Chen, S. (2020) · Cancers · doi:10.3390/cancers12092624 · Cited by 36 · see citing works

Molecular mechanisms of action of Trehalose in cancer: A comprehensive review

Chaitanya, N. S. N., Devi, A., Sahu, S., & Alugoju, P. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118968 · Cited by 37 · see citing works

Geroscience

Kritchevsky, S. B., & Cummings, S. R. (2025) · JAMA · doi:10.1001/jama.2025.11289 · Cited by 38 · see citing works

Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice

Weiss, R., Fernández, E., Liu, Y., Strong, R., & Salmon, A. B. (2018) · Aging · doi:10.18632/aging.101401 · Cited by 36 · see citing works

mGluR5 Allosteric Modulation Promotes Neurorecovery in a 6-OHDA-Toxicant Model of Parkinson’s Disease

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The Impact of New Immunological Therapeutic Strategies on Recurrent Miscarriage and Recurrent Implantation Failure

Parhizkar, F., Motavalli, R., Maleki, L. A., Parhizkar, Z., Pourakbari, R., Kafil, H. S., Danaii, S., & Yousefi, M. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.05.008 · Cited by 36 · see citing works

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype

Gabriel, D., Gordon, L. B., & Djabali, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168988 · Cited by 35 · see citing works

The Cutting Edge: The Role of mTOR Signaling in Laminopathies

Chiarini, F., Evangelisti, C., Cenni, V., Fazio, A., Paganelli, F., Martelli, A. M., & Lattanzi, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040847 · Cited by 35 · see citing works

Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm

Bar‐Tana, J. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09545-w · Cited by 34 · see citing works

Rapamycin/metformin co‐treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice

Reifsnyder, P. C., Flurkey, K., Doty, R. A., Calcutt, N. A., Koza, R. A., & Harrison, D. E. (2022) · Aging Cell · doi:10.1111/acel.13666 · Cited by 34 · see citing works

Chronic oral rapamycin decreases adiposity, hepatic triglycerides and insulin resistance in male mice fed a diet high in sucrose and saturated fat

den Hartigh, L. J., Goodspeed, L., Wang, S. A., Kenerson, H. L., Omer, M., O’Brien, K. D., Ladiges, W., Yeung, R. S. W., & Subramanian, S. (2018) · Experimental Physiology · doi:10.1113/ep087207 · Cited by 34 · see citing works

Nutrient Sensing of mTORC1 signaling in cancer and aging.

Jiang, C., Tan, X., Liu, N., Yan, P.-Q., Hou, T., & Wei, W.-Y. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.08.001 · Cited by 35 · see citing works

The link between Mitochondria and Sarcopenia

Kamarulzaman, N. T., & Makpol, S. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01062-7 · Cited by 33 · see citing works

Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment

Mohamed, M. A., Elkhateeb, W. A., & Daba, G. M. (2022) · Bioresources and Bioprocessing · doi:10.1186/s40643-022-00554-y · Cited by 33 · see citing works

Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study

Ji, N., Mukherjee, N. Z., Reyes, R. M., Gelfond, J., Javors, M. A., Meeks, J. J., McConkey, D. J., Shu, Z.-J., Ramamurthy, C., Dennett, R., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001941 · Cited by 32 · see citing works

Rapamycin in ischemic stroke: old drug, new tricks?

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Activated Phosphoinositide 3-Kinase δ Syndrome: a Large Pediatric Cohort from a Single Center in China

Qiu, L., Wang, Y., Tang, W., Yang, Q., Zeng, T., Chen, J., Chen, X., Zhang, L., Zhou, L., Zhang, Z., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01218-4 · Cited by 29 · see citing works

Roles of autophagy in orthodontic tooth movement

Li, Y., Jacox, L. A., Coats, S., Kwon, J., Xue, P., Tang, N., Zou, R., Wang, X., Kim, Y., Wu, T. J., et al. (2021) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2020.01.027 · Cited by 28 · see citing works

Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor Is the Undercover Boss

Mani, K. M., Javaheri, A., & Diwan, A. (2018) · Comprehensive physiology · doi:10.1002/cphy.c180005 · Cited by 27 · see citing works

Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic cardiomyopathy: results of the RAPACAT trial

Kaplan, J. L., Rivas, V. N., Walker, A. L., Grubb, L., Farrell, A., Fitzgerald, S., Kennedy, S. A., Jauregui, C. E., Crofton, A. E., McLaughlin, C., et al. (2023) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.23.04.0187 · Cited by 26 · see citing works

Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer

Browne, A. J., Kubasch, M. L., Göbel, A., Hadji, P., Chen, D. J., Rauner, M., Stölzel, F., Hofbauer, L. C., & Rachner, T. D. (2017) · Breast Cancer Research · doi:10.1186/s13058-017-0885-7 · Cited by 26 · see citing works

Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension

Baghdadi, M., Nespital, T., Monzó, C., Deelen, J., Grönke, S., & Partridge, L. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101902 · Cited by 27 · see citing works

Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules

Kumar, S., & Lombard, D. B. (2016) · F1000Research · doi:10.12688/f1000research.7821.1 · Cited by 24 · see citing works

Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Luck, C., DeMarco, V. G., Mahmood, A., Gavini, M. P., & Pulakat, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5724046 · Cited by 25 · see citing works

Osteolytic metastasis in breast cancer: effective prevention strategies

Mandal, C. C. (2020) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2020.1807950 · Cited by 25 · see citing works

Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu

Garay, R. P. (2021) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1939306 · Cited by 25 · see citing works

Geroprotector drugs and exercise: friends or foes on healthy longevity?

Elliehausen, C. J., Anderson, R. M., Diffee, G. M., Rhoads, T. W., Lamming, D. W., Hornberger, T. A., & Konopka, A. R. (2023) · BMC Biology · doi:10.1186/s12915-023-01779-9 · Cited by 24 · see citing works

Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes

Liang, H., Nie, J., Skike, C. E. V., Valentine, J. M., & Orr, M. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_10 · Cited by 24 · see citing works

Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment

Willows, J. W., Robinson, M., Alshahal, Z., Morrison, S. K., Mishra, G., Cyr, H., Blaszkiewicz, M., Gunsch, G., DiPietro, S., Paradie, E., et al. (2023) · Aging Cell · doi:10.1111/acel.13784 · Cited by 22 · see citing works

Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model

Royster, G. D., Harris, J. C., Nelson, A. N., Castro, Y., Weitzel, R. P., Tisdale, J. F., Heitmann, R. J., DeCherney, A. H., & Wolff, E. F. (2019) · Reproductive Sciences · doi:10.1177/1933719119828110 · Cited by 22 · see citing works

Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future

Huang, W., Hao, Z., Mao, F., & Guo, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.911876 · Cited by 23 · see citing works

Signaling Pathways in Inflammation and Cardiovascular Diseases: An Update of Therapeutic Strategies

Cucu, I. (2022) · Immuno · doi:10.3390/immuno2040039 · Cited by 20 · see citing works

Aging Biomarkers and Novel Targets for Anti-Aging Interventions

Xu, K., Guo, Y., Li, Z., & Wang, Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_3 · Cited by 20 · see citing works

Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J‐Leprdb mice

Reifsnyder, P. C., Ryzhov, S. V., Flurkey, K., Anunciado‐Koza, R. P., Mills, I., Harrison, D. E., & Koza, R. A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13557 · Cited by 20 · see citing works

Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells

Esch, N., Jo, S., Moore, M., & Alejandro, E. U. (2020) · Journal of Diabetes Research · doi:10.1155/2020/8872639 · Cited by 18 · see citing works

Central action of rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage

Yamamoto, S., Mutoh, T., Sasaki, K., Mutoh, T., & Taki, Y. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.11.015 · Cited by 17 · see citing works

Rapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans

Hagan, M. J., Shenkar, R., Srinath, A., Romanos, S. G., Stadnik, A., Kahn, M. L., Marchuk, D. A., Girard, R., & Awad, I. A. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00006 · Cited by 17 · see citing works

Targeting mTOR Kinase for Cancer Treatment: A Comprehensive Review With Clinical Insights

Hossain, M. T., & Hossain, M. A. (2025) · Drug development research (Print) · doi:10.1002/ddr.70167 · Cited by 15 · see citing works

Targeting a mTOR/autophagy axis: a double-edged sword of rapamycin in spontaneous miscarriage

Li, M., Shen, H.-H., Cao, X.-Y., Gao, X.-X., Xu, F.-Y., Ha, S., Sun, J., Liu, S., Xie, F., & Li, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116976 · Cited by 18 · see citing works

Alternative Rapamycin Treatment Regimens Mitigate the Impact of Rapamycin on Glucose Homeostasis and the Immune System, and Extends Lifespan

Apelo, S. I. A., Pumper, C. P., Baar, E. L., Cummings, N., Brar, H., Kimple, M., Lamming, D. W., & Jc, N. (2016) · Journal of Investigative Medicine · doi:10.1136/jim-2016-000120.45 · Cited by 1 · see citing works

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

Apelo, S. I. A., Pumper, C. P., Baar, E. L., Richardson, N. E., & Lamming, D. W. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw064 · Cited by 134 · see citing works

Blazing a trail for the clinical use of rapamycin as a geroprotecTOR

Konopka, A., Lamming, D., Grasso, B. A., Marrah, R. C., Decker, S. A., Garg, N., Park, Y., Lim, S.-Y., Simcox, J. A., Green, C. L., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00935-x · Cited by 44 · see citing works

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

Liu, Y., Diaz, V., Fernandez, E., Strong, R., Ye, L., Baur, J. A., Lamming, D. W., Richardson, A., & Salmon, A. B. (2014) · Aging · doi:10.18632/aging.100688 · Cited by 68 · see citing works

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Apelo, S. I. A., & Lamming, D. W. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw090 · Cited by 238 · see citing works