The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation
Open accessAbstract
Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of autophagy has been suggested during ferroptosis. However, this relationship between autophagy and ferroptosis is still controversial and the autophagy-inducing mediator remains unknown. In this study, we confirmed that autophagy is indeed induced by the ferroptosis inducer erastin. Furthermore, we show that autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/− and LC3B−/−. Consistently, autophagy deficiency caused depletion of intracellular iron and reduced lipid peroxidation, resulting in cell survival during erastin-induced ferroptosis. We further identified that autophagy was triggered by erastin-induced reactive oxygen species (ROS) in ferroptosis. These data provide evidence that ROS-induced autophagy is a key regulator of ferritin degradation and TfR1 expression during ferroptosis. Our study thus contributes toward our understanding of the ferroptotic processes and also helps resolve some of the controversies associated with this phenomenon.
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Cites
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Cited by
Ferroptosis: machinery and regulation
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Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
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Molecular mechanisms of ferroptosis and their involvement in brain diseases
Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402
Organelle-specific regulation of ferroptosis
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Metadata
- Authors
- Park, E., & Chung, S. W.
- Venue
- Cell Death & Disease
- Published
- 2019-10-28
- Volume
- 10
- Issue
- 11
- Pages
- 822-822
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2981370517
- Cited by
- 890
- References
- 27
- FWCI
- 38.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Park, E., & Chung, S. W. (2019). ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation. Cell Death & Disease. https://doi.org/10.1038/s41419-019-2064-5
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